Research Article

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06/21/2011
Colorectal cancer; Kashmir; MTHFR; Polymorphism; Restriction digestion; RFLP

Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism has been widely investigated in different cancers and has been ... more

A.S. Sameer; Z.A. Shah; S. Nissar; S. Mudassar; M.A. Siddiqi
12/06/2011
GSTP1; Kashmir; Polymorphism; Prostate cancer; Restriction digestion; RFLP

Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1. To investigate the GSTP1 Ile105Val genotype ... more

Q. Qadri; A.S. Sameer; Z.A. Shah; A. Hamid; S. Alam; S. Manzoor; M.A. Siddiqi
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Cluster; Fenugreek; Genetic diversity; Polymorphism; RFLP; SDS-PAGE

Protein and DNA polymorphismswere surveyed among seven accessions of wild fenugreek (Trigonellafoenum-graecum L.) to estimate their genetic diversity and relationships. Samples were obtained from diverse ecogeographical areas in Saudi Arabia and Yemen. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of seed storage protein showed genetic variations ... more

E.A. Haliem; A.A. Al-Huqail
04/10/2012
28-bp repeat; ALL; India; Kashmir; Polymorphism; TSER

Thymidylate synthase (TS) is a crucial enzyme in folate metabolism and plays a vital role in DNA synthesis and repair. The most common polymorphism in TS is a unique double (2R) or triple (3R) 28-bp tandem repeat sequence in the enhancer region of the TS gene (TSER). This genetic variation in TSER has been widely investigated and has been implicated as a risk factor for the development of ... more

F.H. Nazki; A. Masood; M.A. Banday; A. Bhat; B.A. Ganai
01/05/2009
meningiomas; metastases; Methylation; Polymorphism; schwannomas; TP53

The p53 tumor suppressor gene is the most frequently mutated gene in human cancer; this gene is mutated in up to 50% of human tumors. It has a critical role in the cell cycle, apoptosis and cell senescence, and it participates in many crucial physiological and pathological processes. Polymorphisms of p53 have been suggested to be associated with genetically determined susceptibility in various ... more

L.O. Almeida; A.C. Custódio; G.R. Pinto; M.J. Santos; J.R.W. Almeida; C.A. Clara; J.A. Rey; C. Casartelli
02/17/2009
Bombyx mori multiple nucleopolyhedrovirus; Molecular markers; Polymorphism; Random amplified polymorphic DNA; Silkworm

The silkworm Bombyx mori L. is particularly susceptible to virus diseases, especially B. mori nucleopolyhedrovirus (BmNPV). Disease resistance, along with high productivity, are important selection criteria for developing commercial hybrids of B. mori. We used bioassays and molecular markers linked to susceptibility/resistance to baculovirus infection to analyze the ... more

L.F.C. Ribeiro; D.B. Zanatta; J.P. Bravo; R.M.C. Brancalhão; M.A. Fernandez
01/13/2009
Polymorphism; Random amplified polymorphic DNA markers; Table grapes; Vitis vinifera

Random amplified polymorphic DNA (RAPD) markers were used to detect polymorphism and to examine relationships among four table grape clones from northwestern Paraná, in southern Brazil. The 10 primers used for RAPD fingerprints generated 126 reproducible fragments, of which 63, 68, 76, and 72 were polymorphic in cultivars Italia, Rubi, Benitaka, and Brasil, respectively. Among the primers, OPP ... more

S.H.Z. Maia; C.A. Mangolin; S.A.O. Collet; M.F.P.S. Machado
02/25/2009
Mitochondrial DNA; Polymorphism; Sea turtles; Single strand conformation polymorphism

Marine turtles are increasingly being threatened worldwide by anthropogenic activities. Better understanding of their life cycle, behavior and population structure is imperative for the design of adequate conservation strategies. The mtDNA control region is a fast-evolving matrilineal marker that has been employed in the study of marine turtle populations. We developed and tested a simple ... more

E.C. Reis; R.M. Albano; A.C.V. Bondioli; L.S. Soares; G. Lôbo-Hajdu; G. Lôbo-Hajdu
06/10/2008
Biomphalaria; Genetic variability; Polymorphism; RAPD-PCR; Schistosomiasis

Schistosomiasis remains one of the most prevalent parasitic infections and has significant economic and public health consequences in many developing countries. Economic development and improvement in standard of living in these countries are dependent on the elimination of this odious disease. For the control of Schistosomiasis, understanding the host/parasite association is important, since ... more

A.L.D. Oliveira; D. Da Silva; E.M. Zanotti-Magalhães; E.M. Zanotti-Magalhães; A.Z. Abdel-Hamid; J.T. Ribeiro-Paes
12/08/2011
Colorectal cancer; Meta-analysis; Polymorphism; VEGF

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains controversial. We made a meta-analysis of the association ... more

L.P. Zhou; H. Luan; X.H. Dong; G.J. Jin; D.L. Man; H. Shang

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