Research Article

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12/19/2012
CNE2 cell line; Nasopharyngeal carcinoma; Sexual dimorphism; STGC3

STGC3 is a potential tumor suppressor in nasopharyngeal carcinoma. We previously found that CNE2 cells that re-expressed STGC3 formed smaller tumors in female mice than in male mice. Here, we investigated the sexual dimorphism of STGC3 as a tumor-suppressor in female and male nude mice injected subcutaneously with pcDNA3.1(+)-STGC3/CNE2 cells. ER-α was ... more

Q. Qiu; B. Hu; Z.C. Chen; X.S. He
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Clinical outcome; Nasopharyngeal carcinoma; p53 codon 72

We conducted a cohort study to investigate whether polymorphisms in p53 at codon 72 are associated with tumor response and survival time of advanced nasopharyngeal carcinoma (NPC) patients treated with radiotherapy. The study population included 127 subjects with NPC who were enrolled at Binzhou Medical University between September 2008 and December 2009. Cox proportional hazard ... more

M.L. Li; Y. Dong; Y.Z. Hao; N. Xu; F.L. Ning; S.S. Chen; J.M. Yu
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Cyclin D1; Nasopharyngeal carcinoma; Survivin

The association between cyclin D1 and survivin protein expressions with radiotherapy sensitivity in patients with nasopharyngeal carcinoma was investigated. Biopsy specimens of 72 patients with nasopharyngeal carcinoma were collected before the initiation of radiotherapy (49 cases were in the radiation-sensitive group and 23 cases were in the radiation-insensitive group). Conventional ... more

S.M. Fu; M.X. Xu; S.M. Lin; Z. Liang; J.H. Cai
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BiCAT; Co-expression networks; Nasopharyngeal carcinoma; Two-way clustering

This study sought to identify and characterize the function of genes as diagnostic markers for Epstein-Barr virus (EBV)-related nasopharyngeal cancer (NPC). The gene expression profile of GSE13597 was downloaded from the Gene Expression Omnibus database, which included 28 EBV-related NPC gene expression profile data sets, 25 disease samples, and 3 control samples. Data were pre-processed ... more

F. Chen; J. Liu; M. Fan; X.M. Wei; Y.L. Xie; L.H. Wang; H. Yang
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Concurrent chemoradiotherapy; Curative effect; Overall survival; Excision repair cross-complementing gene 1 (ERCC1); Nasopharyngeal carcinoma

In this study, the expression of DNA excision repair cross-complementing gene 1 (ERCC1) in local advanced nasopharyngeal carcinoma has been correlated with the efficacy of concurrent chemoradiotherapy. A total of 76 patients diagnosed with undifferentiated nasopharyngeal carcinoma diagnosed by nasopharyngeal biopsy and undergoing single-agent cisplatin chemotherapy (80 mg/m2) with ... more

R. Liang; Y. Lin; Z.H. Liu; X.L. Liao; C.L. Yuan; S.N. Liao; Y.Q. Li
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Gene silencing; Nasopharyngeal carcinoma; siRNA; Survivin

We examined the function of survivin gene expression in patients with nasopharyngeal carcinoma (NPC), as well as small interfering RNA (siRNA) on controlling CNE-2 NPC proliferation and apoptosis. Immunohistological methods, in situ hybridization, and reverse transcription-polymerase chain reaction technique were used to detect survivin protein and mRNA expression. We designed ... more

S.M. Fu; Z.H. Tu; L.Q. Deng; J.H. Cai; Z. Liang; Z.Q. Lin; Y.T. Wang
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Aptamer; Asthma; Nanotechnology; pRNA; siRNA; STAT5b

Activation of the transcription factor signal transducer and activator of transcription 5b (STAT5b) is a key event in the development of asthma. The potent ability of small interfering RNA (siRNA) to inhibit the expression of STAT5b mRNA has provided a new class of therapeutics for asthma. However, efficient delivery of siRNAs remains a key obstacle to their successful ... more

C. Qiu; W.K. Peng; F. Shi; T. Zhang