Research Article

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Intramuscular fat; Intron 1; L-FABP; Marbling; Single nucleotide polymorphism; Swine

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Y.H. Zhang; L.S. Dai; T.H. Ma; S.Z. Wang; J. Guo; F.J. Li; S.M. Zhang; B.X. Sun; D.F. Liu; Y. Gao; J.B. Zhang
01/22/2013
High-resolution melting analysis; Lung cancer; Non-small cell lung cancer; Risk factor; Single nucleotide polymorphism

Although lung cancer (LC) is a highly environmentally associated disease, genetic factors are also thought to play a role in this disease. In recent years, genome-wide association studies have identified various susceptible genetic regions for LC. Herein, we used high-resolution melting analysis to genotype 2 significant single nucleotide polymorphisms previously reported in Caucasians, ... more

H. Wang; Y. Zhao; J. Ma; G. Zhang; Y. Mu; G. Qi; Z. Fang; L. Wang; Q. Fan; Z. Ma
12/17/2012
Breast cancer; DNMT; Single nucleotide polymorphism; susceptibility

Patterns of DNA methylation are established and maintained by a family of DNA methyltransferases (DNMTs). Aberrant promoter DNA methylation of tumor suppressor genes is found in breast cancer. Association studies between DNMT gene polymorphisms and breast cancer in various populations have reported inconsistent results. This study assessed the associations of single nucleotide ... more

M.Y. Sun; X.X. Yang; W.W. Xu; G.Y. Yao; H.Z. Pan; M. Li
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Haplotype; Male infertility; Single nucleotide polymorphism; UBE2B

The ubiquitin-conjugating enzyme 2B gene (UBE2B) is involved in the regular and symmetric organization of the fibrous sheath of sperm flagella. This study aimed to examine the relationship between single nucleotide polymorphisms (SNPs) in UBE2B and infertility in Northeast Chinese men. We carried out a polymerase chain reaction-restriction fragment length polymorphism ... more

Y. Hu; W. Wen; J.G. Yu; S.Q. Qu; S.S. Wang; J. Liu; B.S. Li; Y. Luo
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Breeding value; Candidate gene; Chicken; Economic trait; Single nucleotide polymorphism

Neuropeptide Y (NPY) and gonadotrophin-releasing hormone receptor (GnRHR) are two candidate genes with a wide variety of physiological functions in growth and especially in reproduction processes. We examined the association of one SNP from each of these genes with growth- and egg production-related traits in Mazandaran native chickens. Two hundred and six individuals were genotyped by ... more

S.A. Fatemi; H. Mehrabani-Yeganeh; A. Nejati-Javaremi; S. Niknafs
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Mutation; NOD; SH2B3; Single nucleotide polymorphism

Type 1 diabetes is a chronic progressive autoimmune disease characterized by mononuclear cell infiltration, with subsequent destruction of insulin-producing β-cells. Studies have identified strong associations between type 1 diabetes and several chromosome regions, including 12q24. Association between type 1 diabetes and 12q24 arises from SNP rs3184504; rs3184504 is a nonsynonymous SNP in ... more

Y.J. Li; X.Y. Li; X.R. Guo; Y. Li; B.F. Shen; Y.C. Shi; J.Y. Zhang
12/18/2014
Crohn’s disease; IRGM; Meta-analysis; Single nucleotide polymorphism

This meta-analysis was performed to evaluate the relationships between single-nucleotide polymorphisms (SNPs) in the immunity-related GTPase M (IRGM) gene and the risk of Crohn’s disease (CD). Eleven case-control studies were included, for a total of 5183 CD patients and 5571 healthy controls. Three common SNPs (rs13361189 C>T, rs10065172 C>T, and rs4958847 A>G) in the ... more

Y. Li; S.T. Feng; Y. Yao; L. Yang; Y. Xing; Y. Wang; J.H. You
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Body measurement; Genetic variability; meat quality; Single nucleotide polymorphism; SIRT2

Silent information regulator 2 (SIRT2), a member of the Sirtuin family of class III nicotinamide adenine dinucleotide-dependent protein deacetylases, plays an important role in senescence, metabolism, and apoptosis. This study was conducted to detect potential polymorphisms of the bovine SIRT2 gene and explore their relationships with meat quality and body measurement traits ( ... more

L.S. Gui; W.C. Yang; C.P. Zhao; S.J. Wei; Z.D. Zhao; L.S. Zan
10/31/2014
Chemotherapy; Excision repair cross-complementation group 1; Non-small cell lung cancer; Single nucleotide polymorphism; Survival time

We conducted a cohort study to investigate the role of 3 single-nucleotide polymorphisms of the excision repair cross-complementation group 1 (ERCC1) gene on the response to chemotherapy and clinical outcomes of non-small cell lung cancer (NSCLC). A total of 163 patients with newly diagnosed and histopathologically confirmed primary NSCLC were examined in our study and were ... more

H. Gao; R.C. Ge; H.Y. Liu; Y. Wang; S. Yan
10/20/2014
Capra hircus; Cytokine; Gastrointestinal infection; Single nucleotide polymorphism

Cytokines are small cell-signaling proteins that play an important role in the immune system, participating in intracellular communication. Four candidate genes of the cytokine family (IL2, IL4, IL13, and IFNG) were selected to identify Single Nucleotide Polymorphisms (SNPs) that might be associated with resistance to gastrointestinal endoparasites in ... more

F.A. Bressani; P.C. Tizioto; R. Giglioti; S.L.C. Meirelles; R. Coutinho; C.L. Benvenuti; W. Malagó-Jr.; M.A. Mudadu; L.S. Vieira; L.G. Zaros; E. Carrilho; L.C.A. Regitano

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