Research Article

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Database; Interaction; Investigation; Metabolic pathways; MicroRNA; Target genes

MicroRNAs (miRNAs) are small non-coding RNAs that regulate target gene expression and hence play important roles in metabolic pathways. Recent studies have evidenced the interrelation of miRNAs with cell proliferation, differentiation, development, and diseases. Since they are involved in gene regulation, they are intrinsically related to metabolic pathways. This leads to questions ... more

A.O. Chiromatzo; T.Y.K. Oliveira; G. Pereira; A.Y. Costa; C.A.E. Montesco; D.E. Gras; F. Yosetake; J.B. Vilar; M. Cervato; P.R.R. Prado; R.G.C.C.L. Cardenas; R. Cerri; R.L. Borges; R.N. Lemos; S.M. Alvarenga; V.R.C. Perallis; D.G. Pinheiro; I.T. Silva; R.M. Brandão; M.A.V. Cunha; S. Giuliatti; W.A. Silva
11/08/2011
MicroRNA; Non-invasive prenatal diagnosis; Preeclampsia

Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir-152 and mir ... more

T. Gunel; Y.G. Zeybek; P. Akçakaya; I. Kalelioglu; A. Benian; H. Ermis; K. Aydinli
11/07/2013
3T3-L1 preadipocyte; Adipocyte differentiation; AP-1; FABP4; MicroRNA

We examined the effect of microRNAs on 3T3-L1 adipocyte differentiation and expression of adipocyte-specific gene fatty acid-binding protein 4 (FABP4). We screened and identified adipo-related microRNAs during 3T3-L1 adipocyte differentiation with a microRNA microarray. High expression plasmids of miR-24 and miR-21 were constructed and transfected into 3T3-L1 preadipocytes by ... more

M. Kang; L.M. Yan; Y.M. Li; W.Y. Zhang; H. Wang; A.Z. Tang; H.S. Ou
10/30/2013
Bronchopulmonary dysplasia; Meta-analysis; MicroRNA; Profiling

Over the past several years, several microRNA (miRNA) expression profiling studies have been carried out on bronchopulmonary dysplasia (BPD) in mammalian lung tissues. The most effective way to identify these important miRNAs is to systematically search for similar signatures identified in multiple independent studies. Accordingly, a meta-analysis was conducted to review published miRNA ... more

Y. Yang; J. Qiu; Q. Kan; X.G. Zhou; X.Y. Zhou
10/07/2013
MicroRNA; Northern blot; UV-B radiation; Wheat

MicroRNAs (miRNAs) play critical roles in post-transcriptional gene regulation and act as important endogenous regulators to various stressors. Ultraviolet-B (UV-B) radiation is a major factor influencing crop growth and development. In this study, we isolated a novel wheat miRNA, named Tae-miR6000, and confirmed its expression diversity after UV-B treatments. Additionally, using the ... more

B. Wang; Y.F. Sun; N. Song; X.J. Wang; H. Feng; L.L. Huang; Z.S. Kang
12/04/2014
Alzheimer’s disease; Meta-analysis; MicroRNA; Oxidized low density lipoprotein receptor 1; Polymorphism

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that contributes to dementia in the elderly population. Genome-wide linkage analysis has identified chromosome 12p as the AD-susceptible region, which includes lectin-like oxidized low-density lipoprotein receptor 1 (OLR1). The OLR1 +1073 C/T single-nucleotide polymorphism is located in the 3'- ... more

Y. Kong; J.B. Wu; X. Wang; J.F. Zhao; H. Song; L.D. Yuan
10/20/2014
Interaction network; MicroRNA; Trefoil factor 2 knock-out

Trefoil factors, which bear a unique 3-loop trefoil domain, are a family of small secretory protease-resistant peptides (7-12 kDa) discovered in the 1980s. Trefoil factor 2 (TFF2) is a unique member of trefoil factors family that plays important roles in gastrointestinal mucosal defense and repair. However, few studies have characterized the miRNA expression patterns in TFF2 knock-out ... more

Y. Yin; H.Q. Shan; W. Huang; Y.M. Wu; H. Lu; Y. Jin
07/04/2014
Hepatocellular carcinoma; MicroRNA; Polymorphisms

We investigate the potential association of miR-149C>T and miR-499A>G polymorphisms and the risk of hepatocellular carcinoma (HCC). A matched case-control study of 152 cases and 304 controls were conducted. The miR-149C>T and miR-499A>G genotypes were analyzed using duplex polymerase chain reaction with restricted fragment length polymorphism. HCC patients were more likely to ... more

X.H. Wang; F.R. Wang; Y.F. Tang; H.Z. Zou; Y.Q. Zhao
06/09/2014
Machine learning; MicroRNA; Support vector machine; Target-prediction

MicroRNA (miRNA) plays important roles in cell differentiation, proliferation, growth, mobility, and apoptosis. An accurate list of precise target genes is necessary in order to fully understand the importance of miRNAs in animal development and disease. Several computational methods have been proposed for miRNA target-gene identification. However, these methods still have limitations ... more

L. Li; Q. Gao; X. Mao; Y. Cao
03/24/2014
Interactions of microRNA2target; Leukemia; MicroRNA; Target genes

MicroRNAs are small, non-coding RNAs that regulate gene expression by suppressing mRNA translation or inducing mRNA degradation, and have been implicated in a growing number of diseases. To understand microRNAs’ function, it is vital to identify microRNA2target interactions. This work explores the prediction and extraction of leukemia-associated microRNA2target interactions, based on text ... more

L. Gong; Q. Yan; R. Yang; X. Sun

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