Research Article

Related GMR Articles

Association analysis; Bone mineral density; Osteoporosis; Osteoprotegerin gene; Postmenopausal women; Single nucleotide polymorphisms

Osteoporosis is an important and common complex health problem, particularly in postmenopausal women. It is characterized by a reduction in bone mineral density (BMD) and a deterioration of bone microarchitecture with a consequent increase of fracture risk. The osteoprotegerin (OPG) gene is considered to play an important role in the pathogenesis of osteoporosis. We analyzed SNPs ... more

J.F. Song; Z.Z. Jing; W. Hu; Y.X. Su
Bone mineral density; Osteoporosis; Postmenopausal women; VDR polymorphisms

We investigated associations between vitamin D receptor (VDR) gene polymorphisms, FokI T>C (rs2228570), BsmI G>A (rs1544410), ApaI G>T (rs7975232), and TaqI T>C (rs731236), with bone mineral density (BMD) in postmenopausal Mexican-Mestizo women. Three hundred and twenty postmenopausal women participated, who were classified ... more

A. González-Mercado; J.Y. Sánchez-López; J.A. Regla-Nava; J.I. Gámez-Nava; L. González-López; J. Duran-Gonzalez; A. Celis; F.J. Perea-Díaz; M. Salazar-Páramo; B. Ibarra
Bone mineral density; Genetic variants; Osteoporosis; Osteoprotegerin gene

The purpose of this study was to investigate the association of the g.27667T>A genetic variant in the osteoprotegerin (OPG) gene with bone mineral density (BMD) and osteoporosis. A total of 393 primary osteoporosis subjects and 402 healthy controls were recruited. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were evaluated by Norland XR-46 dual-energy ... more

J.J. Zhao; D.H. Feng; L. Cheng; T. Lu; L. Wang
Bone mineral density; Chinese women; Genetic polymorphism; Osteoporosis; Osteoprotegerin gene; Risk factor

Osteoporosis is a common multifactorial disease in postmenopausal women. This study aimed to investigate the association of the g.27563G>A osteoprotegerin (OPG) genetic polymorphism with bone mineral density (BMD) and osteoporosis. A case-control study was carried out with 435 osteoporosis postmenopausal women cases and 442 age-matched healthy controls. The BMD at the femoral ... more

Y.P. Liu; D.W. Zhao; W.M. Wang; B.J. Wang; Y. Zhang; Z.G. Li
BMD; CYP17; CYP19; Estradiol; Osteoporosis; Polymorphism

Many clinical conditions, including osteoporosis, are associated with serum levels of sex steroids. Enzymes that regulate rate-limiting steps of steroidogenic pathways, such as CYP17 and CYP19, are also regarded as significant factors that may cause the development of these conditions. We investigated the association of two common polymorphisms, in the promoter region (T→C substitution) ... more

M.B. Yilmaz; A. Pazarbasi; A.I. Guzel; S. Kocaturk-Sel; H. Kasap; M. Kasap; I.F. Urunsak; S. Basaran; D. Alptekin; O. Demirhan
Bone mineral density; Bone morphogenetic protein 2 and 4; Genetic association; Osteoporosis; Single-nucleotide polymorphism

We investigated the effect of bone morphogenetic protein 2 and 4 (BMP-2 and -4) gene polymorphisms on bone density in postmenopausal Turkish women with osteoporosis. The frequency of single-nucleotide polymorphisms (SNPs) of BMP-2 and -4 genes was analyzed in 101 osteoporotic-postmenopausal women and 52 postmenopausal women with positive bone mineral density scores. We evaluated the ... more

Z.S. Özkan; D. Deveci; E. Önalan; H. Yüce
Adipose-derived stem cells; Bone defect; Bone morphogenetic protein 2; Osteogenic differentiation; Osteoporosis

Osteoporosis poses a major public health threat in aging societies. Adipose-derived stem cells (ADSCs) are multipotent adult stem cells that have the ability to yield mesenchymal stem cells, and have the potential to undergo osteogenesis and bone regeneration. Bone morphogenetic proteins (BMPs) have been demonstrated to upregulate bone gene expression after mechanical injury and to ... more

H.L. Fu; Z.Y. Diao; L. Shao; D.P. Yang
C-arm fluoroscopy; Computed tomography; Osteoporosis; Percutaneous kyphoplasty; Spine fractures; Spine neoplasms

This study aimed to evaluate the results and complications of image-guided percutaneous kyphoplasty (PKP) using computed tomography (CT) and C-arm fluoroscopy, with finger-touch guidance to determine the needle entry point. Of the 86 patients (106 PKP) examined, 56 were treated for osteoporotic vertebral compression fractures and 30 for vertebral tumors. All patients underwent image- ... more

G.Y. Wang; C.C. Zhang; K. Ren; P.P. Zhang; C.H. Liu; Z.A. Zheng; Y. Chen; R. Fang
Differential expression; Duchenne muscular dystrophy; Protein-protein interaction network

Duchenne muscular dystrophy (DMD), which is caused by mutations in the X-linked dystrophin gene, is a severe and progressive neuromuscular disease with no available cure. By integrating 2 microarray datasets from the Gene Expression Omnibus, we identified differentially expressed genes in 2 stages of DMD and systematically explored their potential disease-related mechanisms using a ... more

D. Wang; Z.J. Wang; X.X. Song; L.H. Pu; X. Li; Y. Wang
Differentially expressed gene; Osteoarthritis; Protein-protein interaction network

The purpose of this study was to identify genes and pathways for osteoarthritis (OA) diagnosis and therapy. We downloaded the gene expression profile of OA from Gene Expression Omnibus (GEO) database including 10 early OA, 9 late OA, and 5 normal control samples. Next, we screened differentially expressed genes (DEGs) between early- and late-stage OA samples comparing with healthy control ... more

Y.C. Zhu; B.Y. Deng; L.G. Zhang; P. Xu; X.P. Du; Q.G. Zhang; B. Yang