Research Article

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01/28/2014
17-α-Methyltestosterone; Biomphalaria glabrata; Endocrine disruptor; Histopathology; Reproductive performance

17-α-methyltestosterone (MT) is a synthetic hormone used in fish hatcheries to induce male monosex. Snails hold promise as possible test models to assess chemicals acting on the endocrine system. Biomphalaria glabrata is an aquatic gastropod mollusk (Pulmonata, Planorbidae) that can be easily maintained in aquaria, predisposing the species for use in ecotoxicological testing. ... more

C.L.G. Rivero-Wendt; A.C. Borges; E.C. Oliveira-Filho; A.L. Miranda-Vilela; M.F.N. Ferreira; C.K. Grisolia
10/24/2013
Comet assay; Endocrine disruptors; Fish hatcheries; Fish micronucleus

17α-Methyltestosterone (MT) is widely used in fish hatcheries of many countries to produce male monosex populations. Its genotoxic risk to fish species is not well known and studies in other in vivo models are still inconclusive. MT was tested for genotoxicity in the fish species Oreochromis niloticus (tilapia), a target species, and Astyanax bimaculatus ( ... more

C.L.G. Rivero-Wendt; A.L. Miranda-Vilela; M.F.N. Ferreira; F.S. Amorim; V.A.G. da Silva; H. Louvandini; C.K. Grisolia
09/08/2009
Comet assay; Medicinal plant; Micronucleus test; Single-cell gel electrophoresis; Tamarindus indica

Tamarindus indica has been used in folk medicine as an antidiabetic, a digestive aid, and a carminative, among other uses. Currently, there is no information in the toxicology literature concerning the safety of T. indica extract. We evaluated the clastogenic and/or genotoxic potential of fruit pulp extract of this plant in vivo in peripheral blood and liver ... more

F.M.V. Silva; M.F. Leite; A.C.C. Spadaro; S.A. Uyemura; E.L. Maistro
09/08/2009
Allium cepa; Chromosomal aberrations; Comet assay; Nuclear abnormalities; Oreochromis niloticus; Water pollution
L.R. Maschio
03/10/2009
Antioxidant; Comet assay; haptoglobin polymorphism; hydrogen peroxide

Human haptoglobin is classified into three major phenotypes: Hp1-1, Hp2-1 and Hp2-2; there are two autosomal alleles Hp*1 and Hp*2, and the Hp*1 allele has two subtypes, Hp*1F and Hp*1S. Haptoglobin acts as an antioxidant, preventing hemoglobin-driven oxidative damage. We used the comet assay to ... more

L.R.S. Moreira; A.L. Miranda-Vilela; I.C.R. Silva; A.K. Akimoto; M.N. Klautau-Guimarães; C.K. Grisolia
04/22/2009
Ambelania occidentalis; Comet assay; Micronucleus test; Mutagenicity assay; Single-cell gel electrophoresis

Ambelania occidentalis is routinely used in folk medicine for treating gastrointestinal disorders, even though there have been no safety trials. We evaluated the genotoxic potential of hydro-alcoholic extracts of this plant in mice; induced DNA damage was assessed in peripheral blood leukocytes and micronucleus induction was assessed in polychromatic erythrocytes from bone marrow. The ... more

L.S. Castro; F.F. Perazzo; E.L. Maistro
08/14/2008
Comet assay; Micronucleus test; Musa paradisiaca; peripheral blood cells; Single-cell gel electrophoresis

Plants are a source of many biologically active products and nowadays they are of great interest to the pharmaceutical industry. In the present study, the mutagenic potential of the Musa paradisiaca fruit peel extract was assessed by the single-cell gel electrophoresis (SCGE) and micronucleus assays. Animals were treated orally with three different concentrations of the extract (1000 ... more

C.U.B. Andrade; F.F. Perazzo; E.L. Maistro
07/29/2008
Comet assay; Micronucleus test; Mutagenesis; Psidium cattleyanum; Single-cell gel electrophoresis

Cattley guava (Psidium cattleyanum Sabine) is a native fruit of Brazil that is popular both as a sweet food and for its reputed therapeutic properties. We examined whether it could damage DNA using the alkaline single-cell gel electrophoresis (comet assay) and the micronucleus test in leukocytes and in bone marrow cells of mice. P. cattleyanum leaf extract was tested at ... more

T.D.A. Costa; S. Vieira; S.F. Andrade; E.L. Maistro
06/14/2011
Caffeic acid; Cinnamic acid; Clastogenic effects; Comet assay; Ferulic acid; Micronucleus test

Phenols are a large and diverse class of compounds, many of which occur naturally in a variety of food plants; they exhibit a wide range of biological effects, including antibacterial, anti-inflammatory, antiallergic, hepatoprotective, antithrombotic, antiviral, anticarcinogenic, and vasodilatory actions. We examined the genotoxic and clastogenic potential of three phenolic compounds: ... more

E.L. Maistro; J.P.F. Angeli; S.F. Andrade; M.S. Mantovani
10/26/2010
Chromosome aberrations; Comet assay; Essential oil; Micronucleus test; Rosmarinus officinalis

Rosmarinus officinalis (rosemary) oil is widely used by the cosmetic, food, and pharmaceutical industries as a fragrance component of soaps, creams, lotions, and perfumes. Although it is popular, potential harmful side-effects of the oil have been described. We investigated the genotoxic and mutagenic potential of essential oil of R. officinalis in rodents, using comet, ... more

E.L. Maistro; S.F. Mota; E.B. Lima; B.M. Bernardes; F.C. Goulart

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