Research Article

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Arg904Gln; Essential hypertension; Meta-analysis; Polymorphisms; TSC

Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls. The pooled results showed no ... more

F. Zhang; Y. Yang; D. Hu; H. Lei; Y. Wang
08/26/2008
deletion; Essential hypertension; Fluorescence in situ hybridization; subtelomere; telomere

Telomere biology is intimately linked to the genetic/environmental etiology of cardiovascular and metabolic diseases and telomere shortening is emerging as an important biomarker disease. The relationship between subtelomeric deletions and genetic hypertension was examined. Fluorescence in situ hybridization was used to directly assess whether there is a loss or gain of subtelomere ... more

S.T. Onrat; A.G. Tomatir
11/04/2011
Albuminuria; Essential hypertension; Lectin-like oxidized low-density lipoprotein receptor 1; Polymorphisms

Albuminuria is an independent predictor of renal and cardiovascular complications in hypertensive subjects. We previously showed that lectin-like oxidized low-density lipoprotein receptor 1 (OLR-1) polymorphisms at G501C are associated with susceptibility to essential hypertension and serum C-reactive protein levels. We have now investigated a possible association between OLR-1 polymorphisms ... more

X.W. Hou; Z.H. Hu; Y. Cui; W. Gao; S.P. Sun; N.F. Wang
09/27/2011
eNOS; Essential hypertension; Han population; Haplotype; SNPs

Endothelial nitric oxide synthase (eNOS) plays an important role in maintaining blood pressure homeostasis and vascular integrity. Polymorphisms in the eNOS gene have been found to be associated with hypertension in different human populations, including Northern and Southern Chinese Han populations. To examine the relationship of three eNOS gene polymorphisms, T-786C ( ... more

J. Li; Y. Cun; W.R. Tang; Y. Wang; S.N. Li; H.R. Ouyang; Y.R. Wu; H.J. Yu; C.J. Xiao
05/24/2011
ClC-Kb; Essential hypertension; Gene polymorphism; Mongolian population; SLC12A3

Abnormalities in renal sodium chloride and water reabsorption play important roles in the development of hypertension. Mutations in the genes involved in renal sodium chloride reabsorption can affect blood pressure. Recently, the R904Q variant of the sodium/chloride transporters, member 3 (SLC12A3) gene and the T481S variant of the chloride channel Kb (ClC-Kb) gene were found to be implicated ... more

P.Y. Chang; X.G. Zhang; X.L. Su
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Essential hypertension; Mongolian population; Single nucleotide polymorphism; TSC

We investigated a possible association between genetic variations in the thiazide-sensitive Na-Cl cotransporter (TSC) gene and essential hypertension (EH) in the Mongolian and Han ethnic groups in Inner Mongolia. Our study included 385 unrelated Mongolian herdsmen and 523 Han farmers. Nine tagSNPs of TSC were identified from the Chinese HapMap database based on pairwise ... more

P.Y. Chang; L.G. Zhao; X.L. Su
11/03/2010
Essential hypertension; Gene polymorphisms; Haptoglobin; Manganese superoxide dismutase

Essential hypertension is a complex and multifactorial trait; genetic and environmental factors interact to produce the final phenotype. Studies have demonstrated association of hypertension with varied gene polymorphisms. However, demonstration of common genetic causes in the general population remains elusive. We investigated a possible association between hypertension and haptoglobin, ... more

A.L. Miranda-Vilela; A.K. Akimoto; P.C.Z. Alves; L.B. Ferreira; G.S. Lordelo; J.G.M. Melo; C.K. Grisolia; S.F. Oliveira; M.N. Klautau-Guimarães
09/21/2010
Endothelial nitric oxide synthase; Essential hypertension; Meta-analysis; Polymorphism

We examined the effect of polymorphisms in the endothelial nitric oxide synthase gene on the risk for essential hypertension in a Han Chinese population through a meta-analysis of data from 15 studies. Associations between increased risk for essential hypertension and 4b/a were obtained in a dominant model and allele contrast (aa + ab vs bb: odds ratio (OR)FE = 1.26, ... more

H.G. Wang; J.L. Wang; P. Chang; F.L. Cao; X.C. Liu; Y.B. Ma; G.X. Zhai; H.Q. Gao
10/30/2013
Carotid artery atherosclerotic disease; Essential hypertension; Gene polymorphism; Paraoxonase (PON)

We investigated the relationships between paraoxonase genetic polymorphisms and essential hypertension in carotid artery atherosclerotic patients. The study included 353 Han participants and 240 Uighur participants from Xinjiang; they were further divided into two groups: essential hypertension with carotid artery atherosclerosis (CAAD group) and essential hypertension without carotid ... more

L. Han; X.J. Xu; X.H. Liang; J. Ma
10/20/2014
Essential hypertension; Gene polymorphism; Gene-gene interaction; Genechip microarray

We explored the interaction of 6 candidate genetic mutations in essential hypertension (EH). The mutations AGT M235T, ACE I/D, eNOS Glu298Asp, ET-2 A985G, ANP T2238C, and NPRC A-55C were detected using a genechip microarray in 100 patients with EH and 97 controls from the Han population living in the Yunnan Province of China. Risks of EH were evaluated with respect to a combination of ... more

D.C. Hu; X.L. Zhao; J.C. Shao; W. Wang; J. Qian; A.H. Chen; H.Q. Zhang; H. Guo; J. Jiang; H.Y. Li

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