Research Article

Related GMR Articles

Hypertensive population; IL6R; PDE4D; Stroke

Genetic factors have been shown to be associated with the risk of stroke. However, due to individual differences, the extent of the association between genetic factors and stroke varies widely. Hypertension is considered one of the most important risk factors for stroke, but it remains unknown whether the genetic association with stroke in a hypertensive population is the same as that in ... more

H.J. Song; X.H. Zhou; L. Guo; F.L. Tian; X.F. Guo; Y.X. Sun
Diabetes mellitus; Genetic susceptibility; Melatonin receptor; MT2; Pregnancy; Single nucleotide polymorphisms

We investigated the association between rs4753426 single nucleotide polymorphisms in the melatonin receptor 1B (MTNR1B) gene and the risk of developing gestational diabetes mellitus (GDM). A total of 516 gravidas (186 with GDM and 330 non-diabetic controls) were enrolled in the study. Genotype and allele frequencies of rs4753426 in the MTNR1B gene were detected by DNA ... more

Y. Zhan; C. Li; Q. Gao; J. Chen; S. Yu; S.G. Liu
Bone tumor; CYP1A1; Genetic susceptibility; Genotype; GSTM1

Tumor gene polymorphisms are often associated with individual susceptibility to genetic diseases. Cytochrome P4501A1 (CYP1A1) and glutathione S-transferase mu 1 (GSTM1) gene polymorphisms are closely related to the susceptibility of the body to chemical carcinogens in the environment. Therefore, we explored the relationship between CYP1A1 and GSTM1 gene ... more

L. Li; J.G. Li; C.Y. Liu; Y.J. Ding
Genetic susceptibility; HLA; Leishmaniasis

Leishmaniasis is a parasitic infectious disease with global repercussions. American cutaneous leishmaniasis (ACL) is endemic in southern Brazil and its pathogenesis varies according to parasite species, immune response, and host genetics. In terms of immunogenetics, many host genes, including HLA (human leukocyte antigen), could be involved in susceptibility to and protection against ACL ... more

R.C. Ribas-Silva; A.D. Ribas; E.C. Ferreira; T.G.V. Silveira; S.D. Borelli
DNMT3B -149C/T polymorphism; Genetic susceptibility; LSCC; Risk

A variety of molecular epidemiological studies have been conducted to examine the association between the DNMT3B -149C/T polymorphism and cancer susceptibility; however, there has been no study investigating the association between the DNMT3B -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma (LSCC) until now. To determine the role of the DNMT3B ... more

X.M. Zhang; S. Li; Q.M. Zhang
Genetic susceptibility; Polymorphism; Protein tyrosine kinase 2; SNP; Type 1 diabetes mellitus

Type 1 diabetes mellitus (T1D) is considered a polygenic disease that is influenced by environmental factors and autoimmune responses to autoantibodies, resulting in metabolic abnormalities. Tyrosine kinase 2 (TYK2) is involved in type I interferon signaling in beta cells, and TYK2 polymorphism rs2304256 has been associated with T1D. We ... more

V. Graciolo; M. Welter; L.P. Campos; B.R. Martins; S.W. Souza; S.N. França; R.R. Réa; G. Picheth; F.G.M. Rego