Brief Note

Related GMR Articles

07/27/2018
Arg72Pro; Endometriosis; eNOS; Glu298Asp; p53; Polymorphism

Endometriosis is characterized by ectopic endometrial tissue and affects millions of women worldwide. The disease leads to various symptoms such as chronic pelvic pain and infertility and does not yet have a well-defined etiology. The pathology is similar to cancer, since endometrial cells are highly proliferative, invade tissues and may be associated with tumor suppressor ... more

T.R. Santos; K.S.Fe Silva; R.C.P.C. Silva; K.K.V.O. Moura; L.A. Guillo; C.L.Ribeiro Júnior; I.R. Costa
02/25/2019
Chronic heart failure; Genotype; Glu298Asp; NOS3 gene; Polymorphism

The eNOS Glu298Asp (rs1799983) polymorphism of the NOS3 gene has been implicated as a risk factor for cardiovascular diseases; however, not all studies find significant associations. We examined this possibility in a Russian (Siberian) population. One hundred patients with chronic heart failure and 40 controls were investigated. PCR analysis was performed ... more

E.S. Goppe; P.E. Maltese; A. Chernova; S.Y. Nikulina; A. Semenchukov; A. Matveeva; E. Manara; M. Bertelli
04/30/2019
CYP2C19*3; Endometriosis; Polymorphism; Steroid

Endometriosis is a pathology that affects women in Brazil and around the world. It is characterized by the presence of endometrial cells outside the uterine cavity, leading to chronic pain, infertility and hormonal cycle deregulations. Ectopic endometrial foci may be responsible for changes in anatomy, in hormonal metabolism, immune and inflammatory systems and the ... more

I.A. Bento; K.S.Fe Silva; K.K.V.O. Moura; C.L.Ribeiro Júnior; I.R. da Costa
04/30/2019
GSTM1; GSTT1; Polymorphism; Prognosis; Sickle cell anemia

Sickle cell anemia is one of the most common genetic diseases in Brazil. This disease has an autosomal recessive inheritance pattern with a point mutation on chromosome 11, which is the substitution of an adenine by thymine. This mutation leads to the exchange of a glutamic acid for a valine at residue 6 of the beta globin chain, resulting in an abnormal form of hemoglobin, the so-called ... more

O.S.Dias Neto; K.S.Fe Silva; A.M. Barbosa; D.A. Rodrigues; M.H. Lagares; I.R. da Costa; K.K.V.O. Moura
04/30/2019
Adolescent; Genetics; Idiopathic; Muscle; Polymorphism; Scoliosis

Several theories have been proposed to explain the etiology of adolescent idiopathic scoliosis (AIS), but none is conclusive. One such theory suggests the primary involvement of muscles due to myopathy, mainly affecting the erector and paravertebral rotator muscles. Studies indicate that there may be an association of AIS with genetic polymorphisms previously ... more

M. Wajchenberg; D.E. Martins; R.P. Luciano; R.C. Araujo; B. Schmidt; A.B.S. Oliveira; E.B. Puertas; S.S. Almeida; F. Faloppa
05/15/2019
Endometriosis; eNOS; Genotype; Infertility; Polymorphism

Endometriosis is a chronic disease with adverse implications for fertility. We investigated the G894T polymorphism in the endothelial nitric oxide synthase gene in fertile and infertile women with endometriosis. This prospective study included a group of 52 women with a laparoscopic diagnosis of endometriosis. DNA was extracted from blood obtained from 47 patients ... more

R.C.P.Ce Silva; L.C. de Faria; K.S.Fe Silva; K.K.V.O. Moura; C.L.Ribeiro Júnior; L.A. Guillo
07/31/2019
GSTM1; GSTT1; Polymorphism; Prostate cancer; Risk factor

Prostate cancer (PCa) is the second most common type of tumor among men over 50 years old and its etiology includes environmental, demographic, and genetic risk factors. We investigated a possible association between GSTM1 and GSTT1 polymorphisms, sociodemographic, and clinical factors with PCa in a population of southwestern Bahia, Brazil. The ... more

L.C.F. de Souza; T.L.S. Brito; A.T. Almeida; Y.P. Muniz; P.B. Nishiyama; C.L. Souza; L. Tomazi
05/31/2020
Atherosclerosis; eNOS T786C; Nitric oxide; Polymorphism; Stent

Atherosclerosis is a multifactorial chronic-inflammatory disease related to endothelial aggression to the intima layer of medium and large caliber arteries. Hyperlipidemia and atherosclerosis cause eNOS to lose its function, producing superoxide and leading to endothelial dysfunction. The nitric oxide derived from eNOS is anti-atherogenic. Single ... more

A.M. Barbosa; O.S.Dias Neto; K.S.Freitas e Silva; I.B. Lima; U.S. Vilarinho; L.C.A. Gianotti; F.O. de Souza; I.R. da Costa; K.K.V.O. Moura

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