Brief Note

Related GMR Articles

10/16/2015
ALOX5; Pharmacogenomics; PTGS2; SNP; VKORC1

Genetic polymorphisms of very important pharmacogenomic (VIP) variants are important for personalized medicine. However, these have not been extensively studied in the Tibetan population. In this study, 82 VIP variants were detected in the Tibetan and Han (HAN) populations from northwestern China. Subsequently, we compared the differences between the Tibetan population and ten populations ... more

T.B. Jin; X.J. Xun; X.G. Shi; D.Y. Yuan; T. Feng; T.T. Geng; L.L. Kang
01/29/2016
CARS; Diabetic nephropathy; FERM3; SNP

Diabetic nephropathy is the leading cause of end-stage kidney disease in the world. Many single nucleotide polymorphisms (SNPs) have been associated with diabetic nephropathy. SNPs at the 4.1 protein ezrin, radixin, moesin domain 3 (FRMD3) and cysteinyl t-RNA synthetase (CARS) genes have a well-established relationship with diabetic nephropathy. However, this association ... more

S. Al-waheeb; M. Alwohhaib; A. Abdelghani; S. Al-Sharrah; E. Al-Shafey; A. Al-Sahow; N. Alyatama; A.A. Dashti; N. Hussain; S. Al-waheeb; M. Alwohhaib; A. Abdelghani; S. Al-Sharrah; E. Al-Shafey; A. Al-Sahow; N. Alyatama; A.A. Dashti; N. Hussain; S. Al-waheeb; M. Alwohhaib; A. Abdelghani; S. Al-Sharrah; E. Al-Shafey; A. Al-Sahow; N. Alyatama; A.A. Dashti; N. Hussain
02/22/2016
Brazilian women; Breast cancer; p53 protein; Restriction enzymes; SNP; TP53

The association between TP53 gene polymorphisms and breast cancer (BC) in Brazilian women is a controversial topic. In this cross-sectional study, we evaluated the association between clinical pathological variables and three polymorphisms (TP53*11, TP53*72, and TP53*248) in BC patients and controls. Genomic DNA was extracted from the blood cells of 393 ... more

B.C. Almeida; J.P.F.O. Kleine; C.M. Camargo-Kosugi; M.R. Lisboa; C.N. França; J.P. França; I.D.C.G. Silva; B.C. Almeida; J.P.F.O. Kleine; C.M. Camargo-Kosugi; M.R. Lisboa; C.N. França; J.P. França; I.D.C.G. Silva
10/24/2016
Autoimmunity; CD40; qPCR; Rheumatoid arthritis; SNP

The CD40 pathway is involved in the development and pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). Two single nucleotide polymorphisms (SNPs) in the CD40 gene, rs1883832 and rs4810485, are associated with susceptibility to inflammatory and autoimmune diseases and are thought to alter CD40 expression at the mRNA and protein level ... more

I.V. Román-Fernández; D.F. Ávila-Castillo; S. Cerpa-Cruz; S. Gutiérrez-Ureña; J. Hernández-Bello; J.R. Padilla-Gutiérrez; Y. Valle; M.G. Ramírez-Dueñas; A.L. Pereira-Suárez; J.F. Muñoz-Valle
11/03/2016
High-resolution melting; Pinctada fucata; SNP; Transcriptome sequencing

The pearl oyster Pinctada fucata is an important commercial marine shellfish that is cultured for producing saltwater pearls. In this study, 468 single nucleotide polymorphisms (SNPs) were screened from P. fucata transcriptome data, and 119 polymorphic SNPs were successfully isolated by a two-step small-amplicon high-resolution melting assay. Of ... more

S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu; S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu; S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu
12/01/2017
Carcass composition; Carcass quality; Growth; SNP
The objective of the current study was to evaluate single
nucleotide polymorphisms (SNP) for potential growth and carcass trait
associations located in two previously described quantitative trait loci
(QTL) regions associated with bovine respiratory disease. A population
of 323 crossbred steers sired by five purebred sire breeds between 2010- ... more
S. Mizell; S.L. Miller; A.M. Royer; K.J. Thornton; M.D. Garcia
09/26/2019
Blanco Orejinegro; Coefficient of adaptability; Heat tolerance coefficient; Sanmartinero; SNP

The aim of this study was to perform a genome wide association study for the coefficient of adaptability, the heat tolerance coefficient, age at first calving and calving interval, using 58,868 and 57,482 single nucleotide polymorphisms obtained from 1262 Blanco Orejinegro and 742 Sanmartinero individuals, implementing a single-step-genomic-BLUP (ssGBLUP) ... more

C. De León; C. Manrique; R. Martínez; J.F. Rocha
12/31/2019
Artificial neural network; Classification; Decision tree; Genome-wide analysis; Milk yield; SNP

We compared two techniques of machine learning for the identification of cows that will be good producers of milk based on their genome-wide information. Data from a genome-wide genotyping panel, consisting of 164312 single nucleotide polymorphism markers (SNPs), within the 29 autosomal chromosomes, from 1092 Holstein cow samples were used for this study. ... more

E. Rodríguez; J. Waissman; P. Mahadevan; C. Villa; B.L. Flores; R. Villa
09/25/2015
Coronary artery disease; IL-17A; IL-17F; Polymorphism

A case-control study was conducted to investigate the association between genetic variants of IL-17A rs2275913 and IL-17F rs763780 and the development of coronary artery disease (CAD) in a Chinese population. A total of 306 individuals with CAD and 306 unaffected individuals were enrolled from the Zhengzhou People’s Hospital between May 2012 and May 2014. The IL-17A ... more

G.Y. Geng; H.L. Liu; Y.J. Zhao; L. Wu; L. Mao; N. Ba
09/28/2015
DNA repair genes; Osteosarcoma; Overall survival; Polymorphism

We conducted a perspective study to investigate the role of ERCC1 (rs11615), ERCC2 (rs13181 and rs1799793), ERCC4 (rs1800067), and ERCC5 (rs17655) in NER pathway in the prognosis of osteosarcoma patients. In total, 146 osteosarcoma patients were recruited between 2008 and 2013. ERCC1 rs11615, ERCC2 rs13181 and rs1799793, ERCC4 rs1800067, and ERCC5 rs17655 gene polymorphisms were assessed ... more

M.J. Wang; Y. Zhu; X.J. Guo; Z.Z. Tian

Pages