Brief Note

Related GMR Articles

Meta-analysis; NAT2; Pancreatic cancer; Polymorphism; susceptibility

N-acetyltransferase 2 (NAT2) is an essential phase II enzyme in the metabolism of aromatic and heterocyclic amines and of hydrazines. NAT2 activity can be divided into three phenotypes: rapid, intermediate, and slow. Studies identifying an association between NAT2 polymorphism and the risk of pancreatic cancer have shown conflicting results. In order to assess this relationship ... more

J.X. Liang; W. Gao; Y. Liang; X.M. Zhou
Breast cancer; KRAS; let-7; Polymorphism

Breast cancer (BC) is a common malignancy affecting women, with increasing incidences of this disease in China every year. Recent studies have extensively investigated a single nucleotide polymorphism in the let-7 miRNA binding site of the 3'-untranslated region of KRAS mRNA. The aim of this study was to determine the genotype frequency of the KRAS rs712 polymorphism, ... more

X. Huang; Y. Yang; Y. Guo; Z.L. Cao; Z.W. Cui; T.C. Hu; L.B. Gao
Meta-analysis; Polymorphism; rs7903146; T2DM; TCF7L2

Type 2 diabetes mellitus (T2DM) is a chronic disease caused by genetic and environmental factors. T2DM has been associated with specific polymorphisms in the TCF7L2 gene. This study evaluates the relationship between the rs7903146 locus polymorphism of the TCF7L2 gene and T2DM susceptibility through meta-analysis; the overall aim is to provide a basis for evidence-based ... more

X.H. Liu; C.G. Xie; Y. An; X.X. Zhang; W.B. Wu
Breast cancer; Chemotherapy; Glutathione S-transferases; Polymorphism

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment ... more

P. Yuan; L. Yuan; B.L. Xu; C.Z. Wang; H.Z. Yang; Y. Li
Breast cancer; MTHFR; Polymorphism; Risk

We performed a case-control study to investigate the association between single nucleotide polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This case-control study included 216 breast cancer cases and 216 controls. The MTHFR 677C/T and 1298A/C gene polymorphisms were assessed by polymerase chain reaction restriction fragment length ... more

X.F. Zhang; T. Liu; Y. Li; S. Li
NLRP3; Polymorphism; Primary gout

We conducted a case-control study to investigate the association between 3 common NALP3 polymorphisms (rs10754558, rs7512998, and rs12137901) and the susceptibility to primary gout. A total of 320 patients with primary gout and 320 controls were included in this study. The genotyping of NALP3 rs10754558, rs7512998, and rs12137901 were conducted by polymerase chain ... more

L.F. Wang; Y.J. Ding; Q. Zhao; X.L. Zhang
Genotype; Goat; Milk protein; Polymorphism; SDS-PAGE

This study evaluates the relationship between the genotype and milk protein components in goats. Milk samples were collected from cloned goats and normal white goats during different postpartum (or abortion) phases. Two cloned goats, originated from the same somatic line of goat mammary gland epithelial cells, and three sexually reproduced normal white goats with no genetic relationships ... more

H. Xing; B. Shao; Y.Y. Gu; Y.G. Yuan; T. Zhang; J. Zang; Y. Cheng
Case-control study; Crohn’s disease; Meta-analysis; Polymorphism; Tumor necrosis factor-α

We investigated the associations between 2 major tumor necrosis factor-α (TNF-α) polymorphisms, rs1799724 C>T and rs1800629 G>A, and the susceptibility to Crohn’s disease (CD) using a meta-analysis framework. The PubMed, EBSCO, Ovid, Wiley, Web of Science, WANFANG, and VIP databases (last updated search in October 2014) were comprehensively searched for relevant ... more

Y.Q. Mao; S.Q. Dong; M. Gao
Acute pancreatitis; Interleukin-10; Polymorphism

We conducted a case-control study to investigate the possible association between three common single nucleotide polymorphisms in interleukin-10 (IL-10) and the development of acute pancreatitis in a Chinese population. Between January 2013 and December 2014, 255 patients with acute pancreatitis and 255 control subjects were recruited for the study. Genotyping of IL-10 rs1800896, ... more

H.L. Jia; P.L. Sun; C.Q. Lu
Alcohol dehydrogenase 1C; Meta-analysis; Pancreatitis risk; Polymorphism

Numerous studies have focused on the relationship be­tween alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. Thus, we conducted a meta-anal­ysis to more precisely estimate this association. Relevant publications were searched in several widely used ... more

F. Fang; J. Pan; G.H. Su; L.X. Xu; G. Li; Z.H. Li; H. Zhao; J. Wang