Research Article

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Alcoholism; Apoptosis; blood; Cerebral ischemia; miRNA; morphology

One of the main global causes of mortality is cerebral ischemia. Studies report that alcohol abuse causes health problems, aggravating the conditions of neurological diseases. The role of microRNAs has been highlighted in the literature as biomarkers in various types of diseases, including neurological disorders. Evidence of dysregulation of serum miRNAs related to ... more

P.C. Novais; F.S.L. Neto; M.Lde A. Cirino; L.B. Porsani; J.P. da Silva; I.S. Gula; deT. Durand; C.A.M. de Carvalho; B.C. Schimming; deF.G.S. Tazima; C.G. Carlotti; B.O. Colli; D.Pda C. Tirapelli; L.F. Tirapelli
Astrocytoma; Glioblastoma; Polymorphism; XRCC1

XRCC genes (X-ray cross-complementing group) were discovered mainly for their roles in protecting mammalian cells against damage caused by ionizing radiation. Studies determined that these genes are important in the genetic stability of DNA. Although the loss of some of these genes does not necessarily confer high levels of sensitivity to radiation, they have been found to represent ... more

A.C. Custódio; L.O. Almeida; G.R. Pinto; M.J. Santos; J.R.W. Almeida; C.A. Clara; J.A. Rey; C. Casartelli
Astrocytoma; Glioblastoma; GSTP1; Polymorphism

Glutathione S-transferases (GSTs) constitute a superfamily of ubiquitous multifunctional enzymes that are involved in the cellular detoxification of a large number of endogenous and exogenous chemical agents that have electrophilic functional groups. People who have deficiencies in this family of genes are at increased risk of developing some types of tumors. We examined GSTP1 Ile105Val ... more

A.C. Custódio; L.O. Almeida; G.R. Pinto; M.J. Santos; J.R.W. Almeida; C.A. Clara; J.A. Rey; C. Casartelli
Astrocytoma; Glioblastoma; Polymorphism; XRCC3

The gene XRCC3 (X-ray cross complementing group 3) has the task of repairing damage that occurs when there is recombination between homologous chromosomes. Repair of recombination between homologous chromosomes plays an important role in maintaining genome integrity, although it is known that double-strand breaks are the main inducers of chromosomal aberrations. Changes in the XRCC3 ... more

A.C. Custódio; L.O. Almeida; G.R. Pinto; M.J. Santos; J.R.W. Almeida; C.A. Clara; J.A. Rey; C. Casartelli
Glioblastoma; ionizing radiation; MicroRNAs; miR-21; Neurospheres; Temozolomide

Glioblastomas are the most common primary malignant brain tumors, and despite current advances in therapy, they are still extremely resistant to treatment. The tumorigenic potential of glioblastomas is due to a subpopulation of neoplastic cells, called cancer stem cells (CSCs), which in culture form a suspension cluster called neurospheres. Their properties include ... more

A.R. Rodrigues; F.S.L. Neto; L.G. Lourenço; F.A. Trevisan; M.L.A. Cirino; B. Nery; F.M. Peria; G. Pereira-da-Silva; M.F.G.S. Tazima; L.F. Tirapelli; D.G. Tiezzi; C.G.Carlotti Junior; D.P.C. Tirapelli
Avian influenza virus; Chicken embryo fibroblast; H9N2; miRNA

There is limited information about microRNAs (miR­NAs) in H9N2 subtype influenza virus-infected chicken cells or tissues. In this study, 10,487,469 and 13,119,795 reads were obtained from in­fected and non-infected chicken embryo fibroblasts, respectively. Seven hundred and thirty-six and 1004 miRNAs, including mature miRNAs and precursors, were obtained from the infected and non-infected ... more

X. Peng; Q.S. Gao; L. Zhou; Z.H. Chen; S. Lu; H.J. Huang; C.Y. Zhan; M. Xiang
Expression pattern; Flower bud; Male sterility; miRNA

MicroRNAs (miRNAs) are a class of non-coding endogenous negative regulators that regulate gene expression at both the transcriptional and post-transcriptional levels. However, little is known about the expression characteristics of miRNAs during pollen development in Brassica oleracea. In this study, five known and three novel miRNAs were identified and their expression patterns were ... more

J.H. Song; J. Yang; F. Pan; B. Jin
Giant panda; Lactation; Mammary gland; miRNA

The giant panda (Ailuropoda melanoleuca) is one of the world’s most endangered mammals, and it has evolved several unusual biological and behavioral traits. During puberty, pregnancy, lactation, and involution, the mammary gland undergoes profound morphological and functional changes. A large number of microRNAs (miRNAs) have been identified to be involved in mammary gland ... more

C.D. Wang; K. Long; L. Jin; S. Huang; D.H. Li; X.P. Ma; M. Wei; Y. Gu; J.D. Ma; H. Zhang
Breast cancer; ILIA; Insertion/deletion; miRNA; Polymorphism

The insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of interleukin-1A (IL1A) has been studied intensively and has been shown to affect tumor risk. We studied the frequency of the IL1A gene polymorphism rs3783553 and evaluated its relationship with breast cancer (BC). A hospital-based case-control study comprising 228 patients with histologically ... more

X. Huang; Y. Yang; Z.W. Cui; J. Wang; L.B. Gao; X. Huang; Y. Yang; Z.W. Cui; J. Wang; L.B. Gao
DNA; miRNA; mRNA; Next-generation sequencing; Phalaenopsis; PhalDB

The orchid family Orchidaceae is one of the largest families of angiosperms; it includes approximately 35,000 species, displays a wide range of unique flower shapes and is a valued ornamental crop. Among the various species of orchids, the Phalaenopsis genus is the most widely commercialized among blooming potted plants. Our aim was to provide in-depth ... more

C.Y. Lee; K.K. Viswanath; J.Z. Huang; C.P. Lee; C.P. Lin; T.C. Cheng; B.C. Chang; S.W. Chin; F.C. Chen