Research Article

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Bone mineral density; Osteoporosis; Postmenopausal women; VDR polymorphisms

We investigated associations between vitamin D receptor (VDR) gene polymorphisms, FokI T>C (rs2228570), BsmI G>A (rs1544410), ApaI G>T (rs7975232), and TaqI T>C (rs731236), with bone mineral density (BMD) in postmenopausal Mexican-Mestizo women. Three hundred and twenty postmenopausal women participated, who were classified ... more

A. González-Mercado; J.Y. Sánchez-López; J.A. Regla-Nava; J.I. Gámez-Nava; L. González-López; J. Duran-Gonzalez; A. Celis; F.J. Perea-Díaz; M. Salazar-Páramo; B. Ibarra
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Bone mineral density; Genetic variants; Osteoporosis; Osteoprotegerin gene

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Bone mineral density; Genetic variant; Osteoprotegerin gene; Primary osteoporosis; Risk factor

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Myostatin (MSTN) is a member of the transforming growth factor-β superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic frag­ments of MSTN were screened for single nucleotide polymorphisms (SNPs) in a hybrid of Culter alburnus (♀) x Ancherythroculter nigro­cauda (♂) individuals from a commercial hatchery ... more

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Association analysis; Body measurement; Cattle; CDK6 gene; SNP polymorphism

Cyclin-dependent kinase 6 (CDK6) is a key element of D-type cyclin holoenzymes. It is involved in the regulation of the G1-phase of the cell cycle and is considered to be an important candidate gene for selection of body measurement traits through marker-assisted selection. We cloned the promoter sequence of this gene in bovines and found it to share high similarity with that of the human ... more

Y.F. Liu; L.S. Zan; W.T. Cui; Y.P. Xin; Y. Jiao; K. Li
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Association analysis; Genetic polymorphisms; susceptibility; Toll-like receptor 4; Type 2 diabetes mellitus

Toll-like receptor 4 (TLR4) is potentially an important gene affecting the susceptibility to type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate whether genetic polymorphisms of the TLR4 gene are associated with T2DM susceptibility. This potential association was analyzed in 668 T2DM patients and 672 healthy controls by polymerase chain reaction- ... more

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APOA5 gene; APOC3 gene; Association analysis; Kele pig; meat quality

Apolipoprotein A5 (APOA5) and C3 (APOC3) genes are involved in the PPAR lipid metabolism pathway and thus associated with elevated triglyceride levels. However, whether APOA5 and APOC3 genetic polymorphisms affect intramuscular fat deposition and other meat quality traits remains unknown in pigs. One hundred and seventy-one Kele pigs were sampled to ... more

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Association analysis; Growth performance; Promoter; STAM2 gene; Wuchuan Black cattle

The STAM protein plays an important role in the cytokine-related JAK/STAT pathway. We selected the STAM2 gene as a candidate gene that could be linked to growth performance in analysis of a Chinese cattle breed (Wuchuan Black cattle). We examined genetic variants in the promoter region of the STAM2 gene and their associations with eight growth traits in 159 individuals. ... more

Y.Q. Yang; Y.T. Hui; R.Y. Liu; R.G. Jiao; Y. Gong; Y.Y. Zhang; H.Q. Xie
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Association analysis; Multidrug resistance 1 gene; Prostate cancer; Risk factors; Single-nucleotide polymorphism

Prostate cancer is one of the most common malignancies in men. The multidrug resistance 1 gene (MDR1) is an important candidate gene for prostate cancer. The aim of this study was to evaluate the association between MDR1 gene polymorphisms and the risk of prostate cancer. MDR1 gene polymorphism and its association with the risk of prostate cancer were ... more

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