Research Article

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Bioinformatics; Conserved domains; Homology modeling

The Allium genus stands out for its uses in human food and also for its medicinal properties. Many representatives of the Amaryllidaceae family are known for producing mannose binding lectins (MBL). In plants, lectins act as reserves of proteins that can be used for plant growth and development and also in defense against herbivores and pathogens, being ... more

H.J. Jimenez; L.S.S. Martins; R. Carvalho; A.V.V. Montarroyos; R.M.Moraes Filho
09/13/2013
Chromonephthea braziliensis; Mutagenicity; Secondary metabolites; Toxicity

Coral reefs are diverse ecosystems that have a high density of biodiversity leading to intense competition among species. These species may produce unknown substances, many with pharmacological value. Chromonephthea braziliensis is an invasive soft coral from the Indo-Pacific Ocean that is possibly transported by oil platforms and whose presence can be a threat to a region’s ... more

R.M. Carpes; B.G. Fleury; B.G. Lages; A.C. Pinto; C.A.F. Aiub; I. Felzenszwalb
03/22/2012
Cerrado; Dimorphandra mollis; DNA extraction; High-quality DNA; Polysaccharide-free DNA; Secondary metabolites

Dimorphandra mollis (Leguminosae), known as faveiro and fava d’anta, is a tree that is widely distributed throughout the Brazilian Cerrado (a savanna-like biome). This species is economically valuable and has been extensively exploited because its fruits contain the flavonoid rutin, which is used to produce medications for human circulatory diseases. Knowledge ... more

H.A.V. Souza; L.A.C. Muller; R.L. Brandão; M.B. Lovato
08/25/2014
Casearia sylvestris; Cultivated crops; DNA extraction; Secondary metabolites; Tropical species

Purified genomic DNA can be difficult to obtain from some plant species because of the presence of impurities such as polysaccharides, which are often co-extracted with DNA. In this study, we developed a fast, simple, and low-cost protocol for extracting DNA from plants containing high levels of secondary metabolites. This protocol does not require the use of volatile toxic reagents such ... more

M.M. Cavallari; M.V.B.M. Siqueira; T.M. Val; J.C. Pavanelli; M. Monteiro; C. Grando; J.B. Pinheiro; M.I. Zucchi; M.A. Gimenes
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Cell wall-degrading enzymes; Computational analysis; Homology modeling; Parasitism resistance; Tylenchida

Phytoparasitic nematodes can infect a wide range of crop plants, and cause billions of dollars of agricultural losses each year. These parasites represent the largest source of biotic stress experienced by plants. The order Tylenchida comprises the most important parasitic nematodes, particularly the root-knot and cyst nematodes. These parasitic organisms obtain nutrients to support their ... more

R.M.Moraes Filho; L.S.S. Martins; R.M.Moraes Filho; L.S.S. Martins
08/07/2015
Beta vulgaris; Bioinformatics; EST; GSS; MicroRNA

Highly conserved endogenous non-coding microRNAs (miRNAs) play important roles in plants and animals by silencing genes via destruction or blocking of translation of homologous mRNA. Sugar beet, Beta vulgaris, is one of the most important sugar crops in China, with properties that include wide adaptability and strong tolerance to salinity and impoverished soils. Seedlings of ... more

J.L. Li; J. Cui; D.Y. Cheng
12/11/2015
Bioinformatics; Clone; LOC339524 gene; Sprague-Dawley rat (Rattus norvegicus)

We cloned the LOC339524 gene in Sprague-Dawley (SD) rats and analyzed the structure and function of the protein encoded by it. Based on the known human LOC339524 gene sequences, the full-length coding sequence of the LOC339524 gene in SD rats was cloned and amplified by the polymerase chain reaction using the complementary DNA of SD rats as a template. Bioinformatics analysis showed that ... more

Z.H. Long; H. Li; F. Chen; L.Y. Zou
10/30/2015
Bacteria; Bioinformatics; Fungi; Laccase; Oomycetes; Plant pathogen

To date, research on laccases has mostly been focused on plant and fungal laccases and their current use in biotechnological applications. In contrast, little is known about laccases from plant pathogens, although recent rapid progress in whole genome sequencing of an increasing number of organisms has facilitated their identification and ascertainment of their origins. In this study, a ... more

B.Z. Feng; P.Q. Li; L. Fu; X.M. Yu
10/28/2015
Alveolar bone cell; Bioinformatics; Biological pathway; Diabetes

Alveolar bone osteoblasts are widely used in dental and related research. They are easily affected by systemic diseases such as diabetes. However, the mechanism of diabetes-induced alveolar bone absorption remains unclear. This study systematically explored the changes in human alveolar bone cell-related gene expression and biological pathways, which may facilitate the investigation of ... more

X. Sun; Q.H. Ren; L. Bai; Q. Feng
10/16/2015
Bioinformatics; Chordates; Evolutionary biology; Myogenic regulatory factors

MyoD and MyoG are transcription factors that have essential roles in myogenic lineage determination and muscle differentiation. The purpose of this study was to compare multiple amino acid sequences of myogenic regulatory proteins to infer evolutionary relationships among chordates. Protein sequences from Mus musculus (P10085 and P12979), human Homo sapiens (P15172 and ... more

L.C. Oliani; K.C.F. Lidani; J.E. Gabriel

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