Research Article

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02/01/2023
Meta-analysis; Neurodegenerative diseases; Polymorphisms; Systematic review; VEGF-A

Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are degenerative scleroses with unclear etiology. Vascular endothelial growth factor A (VEGF-A) is a growth factor that plays multiple roles in the central nervous system.  Previous studies indicated a potential association between polymorphisms in this gene and the susceptibility of ALS and ... more

J.O. Costa; C.C.P. Costa; N.S. Lima; K.F. Santos; A.A.S. Reis; R.S. Santos
12/14/2015
Case-control study; COMT; Meta-analysis; Ovarian cancer; Single nucleotide polymorphism; Systematic review

The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ovid, EBSCO, PubMed, CNKI, CBMDISC, VIP, ... more

W. Pan; H. Liao
12/22/2015
AGER; Breast cancer; Lung cancer; Meta-analysis; Polymorphisms

We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National ... more

N.C. Yin; X.P. Lang; X.D. Wang; W. Liu
09/09/2015
Abnormal chromosome; Genetic diseases; Systematic review

We evaluated the system accuracy of noninvasive prenatal diagnosis for abnormal chromosome genetic diseases using cell-free fetal DNA in maternal plasma. Previous studies were searched in the MEDLINE database using the following keywords: “prenatal” and “aneuploidy” and “noninvasive or non-invasive” and “maternal”. Identified studies were filtered using a QUADAS instrument. Four studies ... more

H. Yang; H.B. Xu; T.T. Liu; X.L. He
12/12/2023
Bacteria; Precision genetics; Precision Medicine; Systematic review

Helicobacter pylori is a gram-negative, microaerophilic bacterium and an etiological agent of gastroduodenal diseases, including gastritis, peptic ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. H. pylori affects approximately half of the global population. Most infected patients remain asymptomatic or exhibit non-severe ... more

H.C.O. Santos; D.N. Maciel; A.F.P.L. Ramos; S.B. Santiago; C.C.P. Costa; R.S. Santos; M.S. Barbosa
11/04/2011
Albuminuria; Essential hypertension; Lectin-like oxidized low-density lipoprotein receptor 1; Polymorphisms

Albuminuria is an independent predictor of renal and cardiovascular complications in hypertensive subjects. We previously showed that lectin-like oxidized low-density lipoprotein receptor 1 (OLR-1) polymorphisms at G501C are associated with susceptibility to essential hypertension and serum C-reactive protein levels. We have now investigated a possible association between OLR-1 polymorphisms ... more

X.W. Hou; Z.H. Hu; Y. Cui; W. Gao; S.P. Sun; N.F. Wang
09/08/2015
Osteosarcoma; Polymorphisms; VEGF

The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. Genotype frequencies of the VEGF -2578C/A and -460T/C alleles in controls ... more

H.F. Zhang; J.P. Yan; Y.S. Zhuang; G.Q. Han
08/28/2015
Bone mineral density; Human leukocyte antigen-A; Polymerase chain reaction-sequence-based typing; Polymorphisms; Postmenopausal osteoporosis

Osteoporosis is a common disease characterized by low bone mineral density, deterioration in bone microarchitecture, and increased fracture risk and is more prevalent in postmenopausal women. HLA is a complex gene family; previous studies have shown that it plays an important role in the pathogenesis of osteoporosis among Japanese and Greek populations. Prompted by these findings ... more

S.M. Li; H. Guo; H.J. Yang; M.Q. Lv; D.X. Zhou
08/21/2015
Folate pathway; Gastric adenocarcinoma; Polymorphisms

The folate metabolic pathway, which is involved in DNA synthesis and methylation, is associated with individual susceptibility to several diseases, including gastric tumors. In this study, we investigated four polymorphisms [thymidylate synthase enhancer region, single nucleotide polymorphism thymidylate synthase 5' (TS5'), TS3' untranslated region, and methylenetetrahydrofolate reductase ... more

M.D. Araújo; B.N. Borges; S. Rodrigues-Antunes; R.M.R. Burbano; M.L. Harada
08/14/2015
Angiotensin-converting enzyme; Factor VII; Polymorphisms; Thrombosis; Tissue factor

Recent studies have shown an association between thrombosis and factor VII (FVII), tissue factor (TF), and angiotensin-converting enzyme (ACE). This suggests that individuals with FVII-402 G/A, FVII-401 G/T, TF+5466 A/G, and ACE-287 insertion/deletion (I/D) polymorphisms present an increased risk of venous thrombosis, heart disease, and ischemic stroke compared with controls. In this ... more

F.C.G. Evangelista; D.R.A. Rios; D.D. Ribeiro; M.G. Carvalho; L.M.S. Dusse; A.P. Fernandes; A.P. Sabino

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