Research Article

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12/17/2012
Amazon; Epstein-Barr; Gastric cancer; Polymerase chain reaction; Resection margin

Gastric cancer is one of most frequent causes of death in Brazil. The city of Manaus has one of the highest incidences of this disease in Brazil. The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that is classified as a group 1 carcinogen by the International Agency for Research on Cancer. We obtained biopsies from 6 control subjects and 10 patients with gastric carcinomas living ... more

P.F. de Aquino; P.C. Carvalho; J.Sda Gama Fischer; A.Q.L. de Souza; J.S. Viana; S.R.S. Chalub; A.D.L. de Souza; M.G.C. Carvalho
11/12/2012
Gastric cancer; Meta-analysis; Polymorphism; susceptibility; XRCC1

Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a ... more

B.M. Liu; T.M. Liu; B.S. You; H.Y. You; J. Yang; L. Li; Y.C. He
08/29/2012
DNA methylation; Gastric cancer; LOH; MSI; PAI-1 gene

We explored a possible correlation of genetic instability and CpG methylation in the 5'-flanking region of the PAI-1 gene with clinicopathologic features of gastric cancer in Chinese patients and looked for molecular markers for diagnosing gastric tumor development. Microsatellite instability and loss of heterozygosity of the PAI-1 gene locus D7S515, D7S471 and pai-1 ... more

J. Liu; X. Li; N. Yu; Y.Q. Yang; X. Li; Z.Y. Ye; J.C. Li
08/13/2012
Gastric cancer; Meta-analysis; NQO1 gene; Polymorphism; Risk

The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95% confidence interval (95 ... more

Y. Zhang; Z.T. Wang; J. Zhong
12/19/2014
Chromogenic detection; Gastric cancer; Helicobacter pylori; Stomach cancer; Susceptibility gene; TNF-α

TNF 308 gene polymorphism and IL-10 polymorphism provided evidence in diagnosing some types of cancer. We aimed to explore the relation of gene polymorphism with gastric cancer. A total of 360 cases of gastric cancer patients were included in the study. The genotypes GG, GA, and AA of the interleukin-10-1082 gene (IL-10-1082) and the tumor necrosis factor-alpha gene (TNF- ... more

T. Yu; Q. Lu; X.L. Ou; D.Z. Cao; Q. Yu
12/12/2014
Gastric cancer; Meta-analysis; Prognosis; S100A4

The prognostic role of S100A4 in gastric cancer is still under debate. The present meta-analysis aimed to evaluate the relationship between S10A4 levels and the prognosis of gastric cancer. We performed a meta-analysis of published studies assessing the relationship between S100A4 and gastric cancer prognosis. We used the Revman 5.0 software to perform literature retrieval, article ... more

Y. Wang; L.B. Zhou; X.H. Li
01/24/2014
Folate intake; Gastric cancer; Methylenetetrahydrofolate reductase; Polymorphisms

Folic acid and methylenetetrahydrofolate reductase (MTHFR) may both affect the development of human cancer. We conducted a population-based case-control study in a Chinese population to investigate the potential role of folate intake and MTHFR gene polymorphisms in gastric cancer, and their interaction with infection by Helicobacter pylori and tumor location. A total of ... more

J. Chen; L. Yuan; Y.Q. Duan; J.Q. Jiang; R. Zhang; Z.J. Huang; X.R. Xiao
10/31/2014
Gastric cancer; Gene polymorphism; Interleukin-10; Meta-analysis

Numerous studies have evaluated the association between the human interleukin-10 gene -592C>A polymorphism and gastric cancer risk. However, the results have been inconsistent. This meta-analysis was designed to resolve these controversies. Systematic searches of the electronic databases Embase, PubMed, and Google Scholar were performed to identify relevant studies. A meta-analysis was ... more

M. Qi; D.M. Liu; L.L. Pan; Y.X. Lin
10/27/2014
Differential expression; Gastric cancer; MicroRNAs; Network analysis

To identify potential targets for the early treatment and prevention of gastric cancer, microRNA (miRNA) expression profiles of precancerous lesions of gastric cancer were investigated. The miRNA microarray dataset GSE24839 was downloaded from Gene Expression Omnibus (GEO) and included 10 Helicobacter pylori-related gastritis samples and 10 gastric intestinal metaplasia samples. ... more

X.W. Wang; Y. Wu; D. Wang; Z.F. Qin

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