Research Article

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09/19/2013
Gene polymorphism; Hepatocellular carcinoma; Interleukin-28B; Liver cirrhosis; Meta-analysis; rs12979860

We examined the association of the interleukin-28B (IL-28B) gene rs12979860 T/C polymorphism with development of hepatitis virus-related hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library, and Chinese National Knowledge Infrastructure data bases. Pooled odds ratios (ORs) and ... more

G.J. Suo; Z.X. Zhao
02/06/2015
CYP1A1; Gene polymorphism; Hepatocellular carcinoma; Meta-analysis

Numerous studies have evaluated the association between CYP1A1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. However, the specific association is still controversial. The aim of our study was to clarify the effects of CYP1A1 gene polymorphisms (3801 T>C and A2455G) on HCC risk by conducting a meta-analysis. We conducted searches of the literature published in PubMed and ... more

B.W. Yu; L.Q. Zhang; X.L. Teng; Y. Zhang; L.B. Zou; H.Y. Ying
05/16/2014
Chemotherapy; Gene polymorphism; Lung cancer; Meta-analysis; Platinum; XRCC1

X-ray repair cross complementing group 1(XRCC1) polymorphisms have been implicated in interindividual variability of efficacy of platinum chemotherapy for treating non-small cell lung cancer (NSCLC); however, results of different studies have been inconsistent. We conducted a meta-analysis to investigate the association between polymorphisms in the XRCC1 gene and ... more

L. Li; C. Wan; F.Q. Wen
11/29/2011
Gene polymorphism; Meta-analysis; p53 codon 72; Prostate cancer

We examined whether p53 codon 72 polymorphism confers prostate cancer risk by conducting a meta-analysis. Two investigators independently searched the Pubmed, Embase and CBM databases. This meta-analysis was made of seven case-control studies, that included 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on all the studies showed no significant association ... more

M.S. Li; J.L. Liu; Y. Wu; P. Wang; H. Teng
11/08/2011
Gene polymorphism; Liver cirrhosis; Meta-analysis; Risk; Tumor necrosis factor

TNF-α is a potential proinflammatory cytokine that plays an important role in the pathogenesis of liver cirrhosis. We investigated a possible association between TNF-α -308G>A polymorphism and liver cirrhosis risk by conducting a meta-analysis. Publications addressing the association between TNF-α -308G>A and liver cirrhosis risk were selected from the Pubmed and Embase databases. ... more

D. Chen; J.L. Liu; Y. Liu; J. Zhu; S.W. Wang
08/17/2010
Bladder cancer; Gene polymorphism; Meta-analysis; p53 codon 72

Although there have been many studies investigating a possible association between p53 codon 72 polymorphism and risk of bladder cancer, the results have been inconsistent. We conducted a meta-analysis of six epidemiological studies, which included 597 bladder cancer cases and 731 controls. Patients with bladder cancer had a significantly lower frequency of Pro/Arg [odds ratio (OR) = 0.80 ... more

D.B. Li; X. Wei; L.H. Jiang; Y. Wang; F. Xu
12/04/2013
Congenital heart defects; Gene polymorphism; Meta-analysis; Methylenetetrahydrofolate reductase

Numerous studies have evaluated the association between the maternal C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and congenital heart defect (CHD) risk in the Chinese Han population. However, the specific association is still controversial. Six separate studies with 1089 subjects in the Chinese Han population on the relationship between the C677T ... more

K.H. Chen; L.L. Chen; W.G. Li; Y. Fang; G.Y. Huang
01/16/2013
Esophageal cancer; Gene polymorphism; Meta-analysis; X-ray cross-complementing gene 1

We made a meta-analysis of the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and esophageal cancer (EC) risk. Statistical analysis was performed with the Review Manager version 4.2.8 software program and STATA version 11.0. We selected 16 case-control studies for this meta-analysis, including 3591 EC cases and 5752 controls. Overall, the ... more

Z.Y. Zhang; Y. Xuan; X.Y. Jin; X. Tian; R. Wu
12/17/2012
Gene polymorphism; LOC387715/ARMS2; Meta-analysis; Polypoidal choroidal vasculopathy

We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies. The genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV was assessed by calculating pooled odds ratios (ORs) with 95% ... more

J.J. Jiang; X. Wu; P. Zhou; W.Z. Yu; L.Z. Huang; X.X. Li
11/12/2012
Gastric cancer; Meta-analysis; Polymorphism; susceptibility; XRCC1

Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a ... more

B.M. Liu; T.M. Liu; B.S. You; H.Y. You; J. Yang; L. Li; Y.C. He

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