Research Article

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10/03/2011
Association analysis; Candidate gene; Chicken; Egg number at 300 days of age; Polymorphism; QTL

We looked for variations that could be associated with chicken egg number at 300 days of age (EN300) in seven genes of the hypothalamic-pituitary-gonadal axis, including gonadotrophin-releasing hormone-I (GnRH-I), GnRH receptor (GnRHR), neuropeptide Y (NPY), dopamine D2 receptor (DRD2), vasoactive intestinal polypeptide (VIP), VIP receptor-1 ( ... more

H.P. Xu; H. Zeng; D.X. Zhang; X.L. Jia; C.L. Luo; M.X. Fang; Q.H. Nie; X.Q. Zhang
09/12/2011
Genetic marker; Larus saundersi; Microsatellite; Polymorphism; Saunders’s gull

Nine polymorphic microsatellite loci were isolated, using tetranucleotide repeat oligonucleotide probes from an enriched DNA library of the globally “vulnerable” Saunders’s gull (Larus saundersi), collected from the Yancheng coastal wetland, one of the three remaining breeding sites in China. Six breast muscle tissues and 16 blood samples from 22 gulls and eight eggshell membrane ... more

H.X. Jiang; S.L. Ren; Y.Q. Hou; M. Yang; X.B. Wu
09/09/2011
BMD; CYP17; CYP19; Estradiol; Osteoporosis; Polymorphism

Many clinical conditions, including osteoporosis, are associated with serum levels of sex steroids. Enzymes that regulate rate-limiting steps of steroidogenic pathways, such as CYP17 and CYP19, are also regarded as significant factors that may cause the development of these conditions. We investigated the association of two common polymorphisms, in the promoter region (T→C substitution) ... more

M.B. Yilmaz; A. Pazarbasi; A.I. Guzel; S. Kocaturk-Sel; H. Kasap; M. Kasap; I.F. Urunsak; S. Basaran; D. Alptekin; O. Demirhan
08/30/2011
Aggrecan gene; Disc degeneration; Lumbar; Polymorphism

We investigated a possible association between aggrecan gene polymorphism and lumbar degenerative disc disease in Turkish patients. One hundred 20-30-year-old patients with or without low back pain were selected for the study. Lumbar magnetic resonance imaging was performed on all patients. The patient group had low back pain clinically and degenerative disc disease ... more

O. Eser; B. Eser; M. Cosar; M.O. Erdogan; A. Aslan; H. Yıldız; M. Solak; A. Haktanır
08/16/2011
Invasive species; Microsatellite; Polymorphism; Pseudorasbora parva

The Asiatic topmouth gudgeon, Pseudorasbora parva, is recognized as one of the most invasive fish species in many countries outside of Asia. We isolated and characterized 19 microsatellite loci from P. parva. The polymorphism of these 19 loci was tested on 40 individuals of P. parva sampled from a wild population located in Ezhou, Hubei province of China. The ... more

C. Zeng; Y. Gul; K. Yang; L. Cui; W.M. Wang; Z.X. Gao
08/05/2011
Bipolar disorder; Polymorphism; RELN; Schizophrenia

Reelin is an extracellular signaling protein that plays an important role in the development of the central nervous system. Post-mortem studies have shown lower reelin protein levels in the brains of patients with schizophrenia and bipolar disorder compared with controls. Genetic studies have also shown that mutations in the reelin gene (RELN) increase the risk for schizophrenia ... more

W.J. Kuang; R.F. Sun; Y.S. Zhu; S.B. Li
07/19/2011
5' Anchored PCR; Larimichthys polyactis; Microsatellite markers; Polymorphism; Redlip croaker

Larimichthys polyactis is a commercially important marine fish species in southeast Asia. The population crashed due to overfishing in the 1970s, but has since recovered. We developed 13 novel polymorphic microsatellite markers in L. polyactis using 5' anchored PCR. The characteristics of these loci were estimated by analyzing a sample of 30 individuals. A total of 74 ... more

C.Y. Ma; H.Y. Ma; L.B. Ma
06/14/2011
Astrocytoma; Glioblastoma; Polymorphism; XRCC1

XRCC genes (X-ray cross-complementing group) were discovered mainly for their roles in protecting mammalian cells against damage caused by ionizing radiation. Studies determined that these genes are important in the genetic stability of DNA. Although the loss of some of these genes does not necessarily confer high levels of sensitivity to radiation, they have been found to represent ... more

A.C. Custódio; L.O. Almeida; G.R. Pinto; M.J. Santos; J.R.W. Almeida; C.A. Clara; J.A. Rey; C. Casartelli
05/10/2011
Oxidative stress; Polymorphism; Sickle cell anemia; Superoxide dismutase

Oxidative stress may be contributory to the pathophy­siology of the abnormalities that underlie the clinical course of sickle cell anemia. We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. One hundred and twenty-seven patients with sickle cell anemia and 127 healthy controls were recruited into the ... more

S. Sogut; Z. Yonden; H. Kaya; S. Oktar; M. Tutanc; H.R. Yilmaz; A. Yigit; N. Ozcelik; E. Gali
05/10/2011
Coronary artery disease; Cox-2 (-765G > C); Diabetes mellitus; IL-6; Polymorphism

Coronary artery disease is one of the leading causes of mortality and diabetes mellitus is one of its main risk factors due to microvascular and macrovascular complications, such as atherosclerosis. Atherosclerosis is now known to be an inflammatory process mediated by prostaglandins and several interleukins. As both are important in inflammatory processes, we examined Cox-2 (-765G > C ... more

K.K. Ol; B. Agachan; U. Gormus; B. Toptas; T. Isbir

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