Research Article

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08/04/2009
Azoospermia; Chromosomal abnormality; Male infertility; Severe oligozoospermia; Y chromosome microdeletion

Infertility is defined as the inability to conceive a child after one year of regular unprotected intercourse; it is a major health problem affecting about 10-15% of all couples. Infertility is due to a male factor in approximately 50% of cases. The human Y chromosome contains genes necessary for gonadal differentiation into a testis and genes for complete spermatogenesis. We examined the ... more

G.G. Ceylan; C. Ceylan; H. Elyas
06/12/2015
Azoospermia; Male infertility; Severe oligozoospermia; Varicocele; Y chromosome microdeletion

The prevalence of Y chromosome microdeletions among azoospermic, severe oligozoospermic, moderate oligozoospermic, and mild oligozoospermic patients with varicocele-related and idiopathic infertility shows conflicting data in Asian countries. We aimed to detect this frequency in Northeast China, and investigated spermatogenic defects whether associated with varicocele or Y chromosome ... more

R.L. Dai; Y. Hou; F.B. Li; J.M. Yue; Q. Xi; R.Z. Liu
03/09/2007
Azoospermia; Infertility; Molecular markers; Ring-Y

In the present study, we report on the case of a 43-year-old male patient seeking for fertility assistance, who showed a seminal analysis and testicular biopsy of complete azoospermia. Peripheral blood culture for chromosome studies revealed a karyotype of 46 chromosomes with a ring-Y-chromosome that lost the long arm heterochromatin. Molecular analysis of genomic DNA from the patient detected ... more

F.M. Carvalho; E.V. Wolfgramm; I. Degasperi; B.M. Verbeno; B.A. Vianna; F.F. Chagas; F. Paula; I.D. Louro; A.M.S. Perroni
10/24/2013
AZF microdeletion; Azoospermia; Klinefelter's syndrome; Y chromosome

The prevalence of microdeletions of azoospermia factor (AZF) among azoospermic Klinefelter's syndrome (KFS) patients shows conflicting data. We aimed to detect this frequency in a Northeast Chinese population, and to investigate the possible association between AZF microdeletions and KFS by comparison with previous conflicting reports. Eighty men affected with KFS and a random healthy ... more

H.G. Zhang; Z.B. Zhang; R.X. Wang; Y. Yu; X.W. Yu; E. Fadlalla; R.Z. Liu
07/08/2013
AZF microdeletions; Azoospermia; Glutamine and glycine repeat polymorphisms; Karyotype; Non-obstructive oligospermia

Chromosome abnormalities, Y-chromosome microde­letions, and androgen receptor gene CAG and GGN repeat polymor­phisms in infertile Chinese men featuring severe oligospermia and azoospermia were analyzed. Ninety-six fertile men and 189 non-ob­structive infertile men, including 125 patients with azoospermia and 64 with severe oligozoospermia, were studied. Seventeen infertile men (9.0%) ... more

T.T. Han; J. Ran; X.P. Ding; L.J. Li; L.Y. Zhang; Y.P. Zhang; S.S. Nie; L. Chen
11/19/2015
Azoospermia; Azoospermia factor; Fluorescence in situ hybridization; Marker chromosome; Polymerase chain reaction

Y chromosomal microdeletions at the azoospermia factor locus and chromosome abnormalities have been implicated as the major causes of idiopathic male infertility. A marker chromosome is a structurally abnormal chromosome in which no part can be identified by cytogenetics. In this study, to identify the origin of the marker chromosomes and to perform a genetic diagnosis of patients with ... more

C.L. Wei; J.L. Cheng; W.C. Yang; L.Y. Li; H.C. Cheng; J.J. Fu