Research Article

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10/30/2013
Aging; Atrial fibrillation; Growth-associated protein (GAP43); Han nationality; Tyrosine hydroxylase; Xinjiang Uygur

The aim of this study was to explore the changes in gene and protein expressions of tyrosine hydroxylase (TH) and growth-associated protein 43 (GAP43) in aging atrial fibrillation patients of Xinjiang Uygur and Han nationality, and the significance of the changes. Real-time polymerase chain reaction and Western blot analysis were used to detect gene and protein expressions of TH and GAP43 ... more

Y.D. Li; J.X. Li; B.P. Tang; T.Y. Gan; G.J. Xu; X.H. Zhou; H. Li; X. Guo; A. Mahemuti; Q. Sun; Y.Y. Zhang; J. Wang
09/30/2004
Cancer; DmtDNA4977; In situ PCR; Kerns-Sayre syndrome deletion mutation; Mitochondria; Mitochondrial DNA; Real-time PCR

Levels of mtDNA4977 deletions (DmtDNA4977) have been found to be lower in tumors than in adjacent non-tumoral tissues. In 87 cancer patients, DmtDNA4977 was detected by multiplex polymerase chain reaction (PCR) amplification in 43 (49%) of the tumors and in 74 (85%) of the samples of non-tumoral tissues that ... more

M.Angela C. Dani; S.U. Dani; S.P.G. Lima; A. Martinez; B.M. Rossi; F. Soares; M.A. Zago; A.J.G. Simpson
10/14/2008
A3243G mutation; Mitochondria; Mitochondrial disorders; Mitochondrial DNA; Transmitochondrial; Transmitochondrial mice

The mitochondrial A3243G tRNALeu(UUR) mutation associated with a variety of mitochondrial disorders results in a severe respiratory deficiency, an increase in reactive oxygen species (ROS) production and activities of anti-oxidative enzyme in vitro. However, the phenotypic implications of this mutation have not been described in vivo. Here, mitochondria carrying A3243G ... more

J. Li; K. Zhou; X. Meng; Q. Wu; S. Li; Y. Liu; J. Wang
07/04/2014
ATP; Cold stress; Feed efficiency; Heat stress; Mitochondria

We evaluated the adenine nucleotide translocator (ANT) and cytochrome oxidase subunit III (COX III) mRNA expressions in the muscle and liver of Japanese quails presenting high and low feed efficiency (FE), and subjected them to three different environmental temperatures: comfort, heat stress (38°C), and cold stress (10°C). ANT mRNA expression was lower in the liver of heat-stressed ... more

D.M. Voltolini; A.P. Del Vesco; E. Gasparino; S.E.F. Guimarães; A.R.Oliveira Neto; E. Batista; A.P.S. Ton
01/23/2015
Astragaloside IV; Cerebral ischemia-reperfusion; Mitochondria; Penumbra; Peripheral-type benzodiazepine receptors

This study investigated the changes in peripheral benzodiazepine receptors (PBRs) in the penumbra after cerebral ischemia-reperfusion injury, and examined the effects of astragaloside IV (AST) on PBRs in rats. Sixty Sprague-Dawley rats were divided into a sham operation group, a model group, and three AST treatment groups. Cerebral ischemic models were induced by the clue-blocked method ... more

Y.L. Cao; C.F. Chen; A.W. Wang; Y.B. Feng; H.X. Cheng; W.W. Zhang; W. Xin
08/12/2004
Ant; Bee; Larval salivary glands; Polarized-light microscopy; Silk; Silk gland; Silkworm; Wasp

The cocoon, produced by most holometabolous insects, is built with silk that is usually produced by the larval salivary gland. Although this silk has been widely studied in the Lepidoptera, its composition and macromolecular arrangement remains unknown in the Hymenoptera. The macromolecular array patterns of the silk in the larval salivary gland of some meliponids, wasps, and ants ... more

G. Gomes; E.C.M. Silva-Zacarin; R.L.M.Silva de Moraes; F.H. Caetano; F.J. Zara
11/23/2005
Ala16Val polymorphism; APOE gene polymorphism; Atherosclerosis; MnSOD gene polymorphism; ox-LDL; Oxidative damage; Oxidative stress

Oxidized LDL (ox-LDL) is involved in the initiation and progression of atherosclerosis. Many factors can affect the LDL oxidation such as oxidative stress. The present study tested whether ox-LDL levels would be associated with apolipoprotein E (APOE), manganese superoxide dismutase (MnSOD) Ala16Val polymorphisms, and classic cardiovascular risk factors. ox-LDL levels were measured by ... more

M.G.V. Gottlieb; C.H.A. Schwanke; A.F.R. Santos; P.F. Jobim; I.B.M. da Cruz; D.P. Müssel
11/11/2013
Alternative oxidase; Cold; OsAOX1a; Oxidative damage; Rice

Low temperature is a major environmental stress in rice cultivating and production. The alternative oxidase 1 (AOX1) gene is potentially important for genetic engineering to increase cold adaptation. However, previous studies related to this effect have mostly focused on the dicot plants Arabidopsis and tobacco, whereas functional research on rice is limited. In this ... more

C.R. Li; D.D. Liang; R.F. Xu; H. Li; Y.P. Zhang; R.Y. Qin; L. Li; P.C. Wei; J.B. Yang
11/27/2014
DNA repair; Genome instability; Oxidative damage; petite colonies; Saccharomyces cerevisiae

Cassia angustifolia Vahl. (senna) is commonly used in self-medication and is frequently used to treat intestine constipation. A previous study involving bacteria and plasmid DNA suggested the possible toxicity of the aqueous extract of senna (SAE). The aim of this study was to extend the knowledge concerning SAE genotoxicity mechanisms because of its widespread use and its risks ... more

C.R. Silva; A. Caldeira-de-Araújo; A.C. Leitão; M. Pádula
09/09/2011
Aging; Apolipoprotein E; Brazilian-Japanese elderly; Cardiovascular risk; Longevity; Obesity

Study of immigrant populations may contribute to a better understanding of the epidemiology of diseases associated with the aging process. We examined the prevalence of cardiovascular risk factors, including apolipoprotein E (ApoE) polymorphism, in elderly subjects who were born in Japan, migrated to South Brazil and have lived in that region for over 40 years, versus a group of elderly, ... more

N. Terra; Y. Moriguchi; L. Bittencourt; R.S. Trois; J.E.C. Piccoli; I.B.M. Cruz

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