Research Article

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04/22/2009
Ambelania occidentalis; Comet assay; Micronucleus test; Mutagenicity assay; Single-cell gel electrophoresis

Ambelania occidentalis is routinely used in folk medicine for treating gastrointestinal disorders, even though there have been no safety trials. We evaluated the genotoxic potential of hydro-alcoholic extracts of this plant in mice; induced DNA damage was assessed in peripheral blood leukocytes and micronucleus induction was assessed in polychromatic erythrocytes from bone marrow. The ... more

L.S. Castro; F.F. Perazzo; E.L. Maistro
07/29/2008
Comet assay; Micronucleus test; Mutagenesis; Psidium cattleyanum; Single-cell gel electrophoresis

Cattley guava (Psidium cattleyanum Sabine) is a native fruit of Brazil that is popular both as a sweet food and for its reputed therapeutic properties. We examined whether it could damage DNA using the alkaline single-cell gel electrophoresis (comet assay) and the micronucleus test in leukocytes and in bone marrow cells of mice. P. cattleyanum leaf extract was tested at ... more

T.D.A. Costa; S. Vieira; S.F. Andrade; E.L. Maistro
12/30/2003
Comet assay; Micronucleus test; Occupational exposure

The micronucleus (MN) test and the alkaline single cell gel or comet assay were applied to exfoliated cells of the buccal mucous in order to evaluate the genotoxic risk associated with occupational exposure of 10 storage battery renovation workers, and 10 car painters, with age matched controls, in Pelotas, RS, in southern Brazil. In the MN test, 2000 exfoliated buccal cells were ... more

M.G. Martino-Roth; J. Viégas; D.M. Roth
09/08/2009
Comet assay; Medicinal plant; Micronucleus test; Single-cell gel electrophoresis; Tamarindus indica

Tamarindus indica has been used in folk medicine as an antidiabetic, a digestive aid, and a carminative, among other uses. Currently, there is no information in the toxicology literature concerning the safety of T. indica extract. We evaluated the clastogenic and/or genotoxic potential of fruit pulp extract of this plant in vivo in peripheral blood and liver ... more

F.M.V. Silva; M.F. Leite; A.C.C. Spadaro; S.A. Uyemura; E.L. Maistro
08/14/2008
Comet assay; Micronucleus test; Musa paradisiaca; peripheral blood cells; Single-cell gel electrophoresis

Plants are a source of many biologically active products and nowadays they are of great interest to the pharmaceutical industry. In the present study, the mutagenic potential of the Musa paradisiaca fruit peel extract was assessed by the single-cell gel electrophoresis (SCGE) and micronucleus assays. Animals were treated orally with three different concentrations of the extract (1000 ... more

C.U.B. Andrade; F.F. Perazzo; E.L. Maistro
06/14/2011
Caffeic acid; Cinnamic acid; Clastogenic effects; Comet assay; Ferulic acid; Micronucleus test

Phenols are a large and diverse class of compounds, many of which occur naturally in a variety of food plants; they exhibit a wide range of biological effects, including antibacterial, anti-inflammatory, antiallergic, hepatoprotective, antithrombotic, antiviral, anticarcinogenic, and vasodilatory actions. We examined the genotoxic and clastogenic potential of three phenolic compounds: ... more

E.L. Maistro; J.P.F. Angeli; S.F. Andrade; M.S. Mantovani
10/26/2010
Chromosome aberrations; Comet assay; Essential oil; Micronucleus test; Rosmarinus officinalis

Rosmarinus officinalis (rosemary) oil is widely used by the cosmetic, food, and pharmaceutical industries as a fragrance component of soaps, creams, lotions, and perfumes. Although it is popular, potential harmful side-effects of the oil have been described. We investigated the genotoxic and mutagenic potential of essential oil of R. officinalis in rodents, using comet, ... more

E.L. Maistro; S.F. Mota; E.B. Lima; B.M. Bernardes; F.C. Goulart
08/24/2012
Celastraceae; Comet assay; Genotoxic activity; Maytenus robusta; Micronucleus test

Plants belonging to the Celastraceae family have been used in traditional medicine for their analgesic, anti-inflammatory and anti-ulcerogenic properties, among others. Maytenus ilicifolia is the principal species of this family, and is used in the treatment of gastric ulcers. However, owing to its inadequate management in Brazil, the species is becoming extinct and is being ... more

T.M. Raymundo; M. Favilla; R. Niero; S.F. Andrade; E.L. Maistro
01/26/2015
Bocaiúva; Comet assay; Micronucleus test; Oleic acid

Acrocomia aculeata (Jacq.) Lodd. ex Mart. is a plant species commonly used as a foodstuff and also for treating diseases, since it contains high concentrations of antioxidant compounds and monounsaturated fatty acids. Considering its ethnopharmacological relevance, the aim of the present study was to assess the cytotoxic, genotoxic, and mutagenic effects of an oil extracted from ... more

G.K. Traesel; L.H.A. Castro; P.V.B. Silva; R.M. Muzzi; C.A.L. Kassuya; A.C. Arena; S.A. Oesterreich
09/08/2009
Allium cepa; Chromosomal aberrations; Comet assay; Nuclear abnormalities; Oreochromis niloticus; Water pollution
L.R. Maschio

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