Research Article

Related GMR Articles

10/05/2011
Clastogenicity; CYP; Cytotoxicity; Genotoxicity; Hepatocytes; NDEA

In rats, N-nitrosodiethylamine (NDEA) induces tumors mainly in the liver. This could be because various enzymes are responsible for the metabolic activation of NDEA, besides the hepatic NDEA metabolizing enzyme, CYP2E1. We examined NDEA genotoxicity and cytotoxicity in primary cultures of female rat hepatocytes; we also looked at how it affected CYP mRNA expression. Single ... more

C.A.F. Aiub; G. Gadermaier; I.O. Silva; I. Felzenszwalb; L.F.R. Pinto; F. Ferreira; P. Eckl
06/15/2010
Antigenotoxicity; Cytotoxicity; Genotoxicity; Palicourea coriacea; SMART/wing

Palicourea coriacea, popularly known as “douradinha”, is a medicinal plant from the Brazilian Cerrado region used in folk medicine to treat kidney and urethral stones and kidney inflammation. We evaluated the cytotoxic, genotoxic, and possible antigenotoxic activities of an aqueous extract of P. coriacea on somatic cells of Drosophila melanogaster, using the ... more

D.C.S. Passos; H.D. Ferreira; I.L.F.B. Vieira; W.B. Nunes; L.P. Felício; E.M. Silva; C.R. Vale; S.R. Duarte; E.S. Silva; S. Carvalho
10/01/2013
Cytotoxicity; Genotoxicity; Pestalotiopsis guepinii; Pestheic acid

There is a constant search for new cancer treatments that are less aggressive and economically affordable. In this context, natural products extracted from plants, fungi, and microorganisms are of great interest. Pestheic acid, or dihidromaldoxin, is a chlorinated diphenylic ether extracted from the phytopathogenic fungus Pestalotiopsis guepinii (Amphisphaeriaceae). We assessed ... more

J.M.C. Sousa; L.A. Matos; D.F.A. Alcântara; H.F. Ribeiro; L.S. Santos; M.N. Oliveira; L.C. Brito-Junior; A.S. Khayat; A.C. Guimarães; L.A. Cunha; R.R. Burbano; M.O. Bahia
07/03/2013
Antigenotoxicity; Cytotoxicity; Micronucleus test; Salacia crassifolia; Stem bark fractions

Salacia crassifolia (Mart. Ex. Schult.) G. Don., popularly known in Brazil as "bacupari", "cascudo", and "saputá", is a shrub of the Celastraceae family that is unique to the Brazilian Cerrado region. In folk medicine, this plant has been mainly used to treat skin cancer and gastric ulcers. In the present study, the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects ... more

C.C. Carneiro; C.R. Silva; A.C.S. Menezes; C.N. Pérez; L. Chen-Chen
05/13/2013
Central nervous system; Cytotoxicity; Iron; Micronuclei

Iron is the most important metallic chemical element on Earth. Poisoning caused by excessive iron in humans has been associated with pulmonary diseases including neoplasms caused by inhalation of iron oxides. The involvement of iron in neurodegenerative processes has already been described. DNA alterations are induced by iron and other chemical compounds containing this metal; however, ... more

D.D.F.A. Alcântara; H.F. Ribeiro; L.A. Matos; J.M.C. Sousa; R.R. Burbano; M.O. Bahia
04/02/2013
Antibacterial activity; Brine shrimp lethality bioassay; Cytotoxicity; Endophytic fungi; Scapania verrucosa Heeg.; Staphylococcus aureus

We evaluated the antibacterial activity and cytotoxicity of endophytes isolated from Scapania verrucosa Heeg., which belongs to the liverwort class. A total of 49 endophytic fungi were isolated from S. verrucosa and classified into seven genera and one family in our previous study. In this study, the cytotoxic activity of the endophytes was assessed using the brine ... more

J.G. Wu; W. Peng; P.Y. Zeng; Y.B. Wu; J. Yi; J.Z. Wu
05/23/2014
Apoptosis; Cancer; Cytotoxicity; MCF-7; Saudi Arabia

This study investigated the in vitro anticancer activities of a total of 14 wild angiosperms collected in Saudi Arabia. The cytotoxic activity of each extract was assessed against human breast adenocarcinoma (MCF-7) cell lines by using the MTT assay. Among the plants screened, the potential cytotoxic activity exhibited by the extract of Lavandula dentata (Lamiaceae) was ... more

M.A. Ali; A. Farah; F.M. Al-Hemaid; F.M. Abou-Tarboush
01/15/2015
Apoptosis; Apoptotic pathway; Bombyx batryticatus; Cytotoxicity; Hela cells

Anticancer activity of Bombyx batryticatus ethanol extract (BBE) against HeLa cells was studied using cell viability, DNA fragmentation, real-time polymerase chain reaction, and Western blot analyses. The BBE inhibited the growth and induced apoptosis of HeLa cells. The MTT assay indicated that the BBE induced cytotoxicity in HeLa cells in a time- and concentration-dependent ... more

W.P. Wu; J. Cao; J.Y. Wu; H. Chen; D. Wang
09/30/2007
Cyclophosphamide; Cytotoxicity; Lubricant oils; Micronucleus

To ascertain whether used and re-refined lubricant oil absorbed through the skin can produce a genotoxic effect or cytotoxicity in mouse bone marrow cells, we examined the induction of micronucleated erythrocytes of peripheral blood after cutaneous application. Both re-refined and used lubricant oils showed a weak but significant induction of micronucleated polychromatic erythrocytes ... more

C.R. Oliveira-Martins; C.K. Grisolia
08/04/2009
99mTc-MIBI; Genotoxicity; Micronucleus; Radiopharmaceutical

The radiotracer technetium-99m methoxyisobutyl isonitrile (99mTc-MIBI) has been widely used for myocardial blood flow imaging. We investigated the genotoxicity of 99mTc-MIBI in cultured human lymphocytes at the same concentration used in patients. Radioactivity doses were determined in whole blood at 5 min post-injection of 20 mCi 99mTc-MIBI in patients. ... more

S.J. Hosseinimehr; A. Ahmadi; D. Beiki; A. Mahmoudzadeh; M. Babaei; E. Habibi

Pages