Research Article

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Osteoporosis is an important and common complex health problem, particularly in postmenopausal women. It is characterized by a reduction in bone mineral density (BMD) and a deterioration of bone microarchitecture with a consequent increase of fracture risk. The osteoprotegerin (OPG) gene is considered to play an important role in the pathogenesis of osteoporosis. We analyzed SNPs ... more

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A. González-Mercado; J.Y. Sánchez-López; J.A. Regla-Nava; J.I. Gámez-Nava; L. González-López; J. Duran-Gonzalez; A. Celis; F.J. Perea-Díaz; M. Salazar-Páramo; B. Ibarra
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B cell; Bone mineral density; Differentially expressed genes; Enrichment analysis; Functional analysis

We searched for key genes that could accurately predict bone mineral density. The gene expression profile GSE7429 was downloaded from the Gene Expression Omnibus database, which includes 20 samples, 10 with high and 10 with low bone mineral density. The differentially expressed genes (DEGs) were identified with packages in R language. Further, BLASTX was used to obtain COG function ... more

Y. Chen; R.G. Xia