Research Article

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04/13/2010
Colorectal cancer; Kashmir; Polymorphism; Restriction digestion; RFLP; TP53

Two TP53 gene polymorphisms at codon 47 (TP53 Pro47Ser) and at codon 72 (TP53 Arg72Pro) have been associated with susceptibility to various cancers. We carried out a case-control study and examined the genotype distribution of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms (SNPs), using a PCR-RFLP approach, to determine if these two SNPs are ... more

A.S. Sameer; Z.A. Shah; N. Syeed; M.Z. Banday; S.M. Bashir; B.A. Bhat; M.A. Siddiqi
01/04/2013
Hepatocellular carcinoma; MIF-794CATT; Polymorphism; Promoter

Hepatocellular carcinoma (HCC) is one of the most common worldwide malignancies. A relative complete diagnosis system for primary carcinoma of liver has already been established, but the surgical prognosis for HCC, which depends mainly on postoperative pathological classification and data of recurrence and metastasis, lacks valid experimental indicators. Macrophage migration inhibition ... more

T. Yuan; C. Tang; M. Chen; S. Deng; P. Chen
12/13/2013
CCND1; Esophageal squamous cell carcinoma; Polymorphism; PTEN

Cyclin D1 (CCND1) plays a significant role in G1-S transition of cell cycle, and phosphatase and a tensin homologue (PTEN) negatively regulate cell cycle through phosphatidylinositol 3-kinase (PI3K)/AKT signaling. CCND1 and PTEN genetic polymorphisms might induce susceptibility to the occurrence of esophageal squamous cell carcinoma (ESCC). Three hundred and four ESCC patients and 413 ... more

Y. Jang; S.A. Lu; Z.P. Chen; J. Ma; C.Q. Xu; C.Z. Zhang; J.J. Wang
12/04/2013
Cluster; Fenugreek; Genetic diversity; Polymorphism; RFLP; SDS-PAGE

Protein and DNA polymorphismswere surveyed among seven accessions of wild fenugreek (Trigonellafoenum-graecum L.) to estimate their genetic diversity and relationships. Samples were obtained from diverse ecogeographical areas in Saudi Arabia and Yemen. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of seed storage protein showed genetic variations ... more

E.A. Haliem; A.A. Al-Huqail
02/28/2013
Ossification; Polymorphism; Posterior longitudinal ligament; Transforming growth factor-β1

Ossification of the posterior longitudinal ligaments (OPLL) has been considered to be associated with abnormalities of bone metabolism, and transforming growth factor-β1 (TGF-β1) has been demonstrated to affect the bone remodeling process. We investigated two SNPs of the TGF-β1 promoter (-509C>T; rs1800469) and exon 1 (869T>C; rs1982073) in 298 Koreans (98 patients with OPLL and ... more

I.B. Han; A.E. Ropper; Y.J. Jeon; H.S. Park; D.A. Shin; Y.D. Teng; S.U. Kuh; N.K. Kim
10/18/2013
NPP1; Ossification; Polymorphism; Posterior longitudinal ligament; Postoperative progression

Ossification of the posterior longitudinal ligament (OPLL) is a condition of the spine that can cause paralysis by compressing the spinal cord. The aim of this study was to evaluate the possible role of nucleotide pyrophosphatase phosphodiesterase 1 gene (NPP1) polymorphism in the etiology and pathology of the OPLL in Chinese patients. DNA from patients with OPLL (N = 95) and ... more

Z. He; H. Zhu; L. Ding; H. Xiao; D. Chen; F. Xue
09/23/2013
EST-SSR; Grape vine; Polymorphism; Segregation

The objectives of this investigation were to develop and validate the expressed sequence tag (EST)-simple sequence repeat (SSR) markers from large EST sequences, and to study the segregation and distribution of SSRs within two grapevine parental lines. In total, 94 F1 lines crossed between "Early Rose" and "Red Globe" were studied. Approximately 2100 EST-SSR sequences of ... more

E. Kayesh; Y.Y. Zhang; G.S. Liu; N. Bilkish; X. Sun; X.P. Leng; J.G. Fang
09/03/2013
Genetic relationship; Lolium; Polymorphism; RAPD markers; Taxonomy

The genus Lolium is one of the most important groupings of temperate forage grasses, including about eight recognized species that are native to some temperate and subtropical regions of the northern hemisphere. We examined genetic relationships among 18 accessions representing all Lolium species using RAPD markers. Among 50 random primers that we screened, 13 gave ... more

X. Ma; X.Y. Gu; T.T. Chen; S.Y. Chen; L.K. Huang; X.Q. Zhang
07/15/2013
Leptin; Leptin receptor; Polymorphism; Preeclampsia

The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656Asn genotype and ... more

S. Wang; F.Y. Qiao; L. Feng
06/11/2013
GNAQ; Han Chinese population; Polymorphism; Rheumatoid arthritis

Mice that lose Gαq from their immune system can spontaneously develop inflammatory arthritis. Gαq expression in the peripheral blood lymphocytes of rheumatoid arthritis (RA) patients is significantly decreased in comparison to that in healthy individuals, and reduced Gαq expression is closely correlated with RA disease activ­ity. These indicate that Gαq plays critical roles in the ... more

Y. Li; Y. Wang; Y. He; D. Wang; L. Deng; Y. Du; G. Shi

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