Research Article

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11/26/2012
Cancer; CASP-10; Genetic polymorphisms; Meta-analysis; susceptibility

We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529*T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). ... more

S. Yan; Y.Z. Li; J.W. Zhu; C.L. Liu; P. Wang; Y.L. Liu
12/17/2012
Gene polymorphism; LOC387715/ARMS2; Meta-analysis; Polypoidal choroidal vasculopathy

We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies. The genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV was assessed by calculating pooled odds ratios (ORs) with 95% ... more

J.J. Jiang; X. Wu; P. Zhou; W.Z. Yu; L.Z. Huang; X.X. Li
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Gastric cancer; Meta-analysis; Polymorphism; susceptibility; XRCC1

Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a ... more

B.M. Liu; T.M. Liu; B.S. You; H.Y. You; J. Yang; L. Li; Y.C. He
10/04/2012
Glioma risk; MDM2; Meta-analysis; p53; Polymorphisms

Epidemiological studies of the association of variants p53 Arg72Pro and MDM2 single-nucleotide polymorphism 309 (SNP309) with glioma risk have produced inconsistent results. The aim of the current study was to evaluate the association of these 2 variants with glioma susceptibility using a meta-analysis approach. For p53 Arg72Pro, 10 case-control studies including ... more

J.N. Zhang; S.H. Yi; X.H. Zhang; X.Y. Liu; Q. Mao; S.Q. Li; W.H. Xiong; Y.M. Qiu; T. Chen; J.W. Ge
09/26/2012
Arg904Gln; Essential hypertension; Meta-analysis; Polymorphisms; TSC

Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls. The pooled results showed no ... more

F. Zhang; Y. Yang; D. Hu; H. Lei; Y. Wang
09/26/2012
Bladder cancer; Genetic susceptibility; hOGG1; Meta-analysis; Polymorphism

The functional polymorphism Ser326Cys (rs1052133) in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in bladder cancer risk. However, reports of this association between the Ser326Cys polymorphism and bladder cancer risk are conflicting. In order to help clarify this relationship, we made a meta-analysis of seven case-control studies, summing 2521 cases ... more

D.Y. Zhong; H.Y. Chu; M.L. Wang; L. Ma; D.N. Shi; Z.D. Zhang
09/25/2012
Colorectal cancer; Interleukin-10; Meta-analysis; Polymorphism

In order to make a comprehensive assessment of the potential association between two genetic variants in the IL-10 gene promoter, -1082 A>G (rs1800896) and -592 C>A (rs1800872), and colorectal cancer (CRC) risk, we conduced a meta-analysis of seven epidemiological studies, which included 1469 colorectal cancer cases and 2566 controls. Neither of the two polymorphisms had any ... more

Y.M. Zhang; X.C. Zhou; Z. Xu; C.J. Tang
08/13/2012
Gastric cancer; Meta-analysis; NQO1 gene; Polymorphism; Risk

The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95% confidence interval (95 ... more

Y. Zhang; Z.T. Wang; J. Zhong
06/29/2012
Keloid; Meta-analysis; p53 codon 72 polymorphism; susceptibility

Although there is evidence suggesting genetic susceptibility for keloids, studies investigating the association between Arg72Pro polymorphism in the P53 gene and tendency to form keloids have given variable results. We made a meta-analysis of the effects of P53 Arg72Pro polymorphism on keloid risk in the Chinese population by conducting searches of the published literature in ... more

Y. Wu; B. Wang; Y.H. Li; X.G. Xu; Y.J. Luo; J.Z.S. Chen; H.C. Wei; X.H. Gao; H.D. Chen
06/15/2012
Genetic polymorphisms; Meta-analysis; Prostate cancer; PTGS2

Evidence is accumulating that chronic inflammation has an important role in prostate cancer. Two common polymorphisms in the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, rs20417 and rs689470, have been found to alter the risk for prostate cancer, but the various studies are not in agreement. To derive a more precise estimation of this association, all available studies were ... more

H.T. Zhang; Y. Xu; Z.H. Zhang; L. Li

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