Research Article

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Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved in susceptibility to develop COPD. It belongs to the ... more

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Genetic polymorphism; Glioma; Glutathione S-transferases; Perillyl alcohol

GSTM1 (glutathione S-transferase mu 1) and GSTT1 (glutathione S-transferase theta 1) are critical enzymes for detoxification of endogenous and environmental carcinogens. Constitutive GST gene polymorphisms may be associated with increased risk for cancer development. We made an explorative study of a Brazilian population with malignant glioma to determine whether ... more

M.M. Silva; C.O. Da Fonseca; R. Moura-Neto; J.F. Carvalho; T. Quirico-Santos; M.G. Carvalho
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Genetic association; Genetic polymorphism; Holstein cows; Molecular markers

The bovine prolactin (PRL) and bovine growth hormone (bGH) genes exhibit several polymorphisms. Some of them can be detected by molecular techniques using restriction endonucleases, such as RsaI for the PRL gene and MspI for the bGH gene. We examined the relationship between the PRL-RsaI and bGH-MspI polymorphisms and ... more

J.C. Rincón; A. López-Herrera; J.J. Echeverri
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Genetic polymorphism; Hypodontia; Meta-analysis; Msh homeobox 1; Transforming growth factor-β1

We conducted a comprehensive meta-analysis of 4 case-control studies to explore the association between polymorphisms of Msh homeobox 1 (MSX1) and transforming growth factor-β1 (TGF-β1) genes and hypodontia. A total of 643 tooth agenesis cases and 733 healthy controls were included in this study. The meta-analysis results showed that the T allele and T ... more

W. Zhang; H.C. Qu; Y. Zhang
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To evaluate the association between paired box 9 (PAX9) gene polymorphisms and tooth agenesis in isolated humans, we performed a comprehensive meta-analysis. We examined 6 case-control studies, with a total of 855 hypodontia cases and 1201 healthy controls. The G allele and G carrier (AG + GG) of A1031G were positively associated with hypodontia susceptibility. Similarly, the T ... more

W. Zhang; H.C. Qu; Y. Zhang
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Esophageal squamous cell carcinoma; Genetic polymorphism; IGFBP-3; Molecular epidemiology

Insulin-like growth factor binding protein-3 (IGFBP-3) exerts anti-proliferative or pro-apoptotic effects through IGF-dependent as well as IGF-independent mechanisms in vitro. The purpose of this study was to examine the association between genetic variants in IGFBP-3 (rs2270628) and the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese Han population. Five ... more

H.P. Yang; J.F. Liu; J. Rao; X.M. Zhang; H.L. Qian; X.Q. Niu; Z.L. Zhao
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16S rRNA; COI; Crustacean; Genetic polymorphism; Genetic variability; Macrobrachium

The genus Macrobrachium includes prawns, which are widely distributed in lakes, floodplains, and rivers in tropical and subtropical regions of South America. This genus presents nearly 210 known species with great ecological and economic importance. However, few studies are related to the biology of these crustaceans. In this study, we analyzed the genetic variability and ... more

A.L. Guerra; A.V.B. Lima; R.V.Lucato Júnior; M.C. Chiachio; F.G. Taddei; L. Castiglioni
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Bone mineral density; Chinese women; Genetic polymorphism; Osteoporosis; Osteoprotegerin gene; Risk factor

Osteoporosis is a common multifactorial disease in postmenopausal women. This study aimed to investigate the association of the g.27563G>A osteoprotegerin (OPG) genetic polymorphism with bone mineral density (BMD) and osteoporosis. A case-control study was carried out with 435 osteoporosis postmenopausal women cases and 442 age-matched healthy controls. The BMD at the femoral ... more

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Genetic polymorphism; Lung cancer; Meta-analysis; rs401681 (G>A); TERT-CLPTM1L

A genome-wide association study revealed that a single nucleotide polymorphism, CLPTM1L - rs401681 (G>A), located at the 5p15.33 locus was significantly associated with increased risk of various cancers; however, its association with lung cancer is currently inconclusive. In order to explore the relationship between this polymorphism and lung cancer risk more precisely, we ... more

X.L. Zhang; X.J. Zhang; Y. Chen; Y.M. Zhang; Q. Zhang; C.X. Cao; D.Y. Gu; J.F. Shi; Y.L. Gong; J.F. Chen; C.J. Tang
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Genetic polymorphism; Male infertility; MDR1 (ABCB1); P-glycoprotein

Infertility affects 1 in 6 couples and approximately 1 in 25 men. Male factor infertility is a major cause of spermatogenic anomalies, the causes of which are largely unknown. Impaired repro­ductive functions in men might result from physiological, genetic, and/or environmental factors such as xenobiotics. The multi-drug re­sistance1 (MDR1) gene encodes a P-glycoprotein which has ... more

S.E. Aydos; A. Karadağ; T. Özkan; B. Altınok; M. Bunsuz; S. Heidargholizadeh; K. Aydos; A. Sunguroĝlu

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