Research Article

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06/07/2011
BMI; Leptin; MC4R gene; Obesity

Mutations in the melanocortin-4 receptor (MC4R) are associated with severe obesity, independent of their effect on cortisol or thyroid-stimulating hormone levels. We examined a morbidly obese male (BMI = 62 kg/m2) with a binge-eating disorder and eight family members for mutations in the MC4R gene and potential differences in leptin levels. Fifty healthy individuals served as ... more

S. Buchbinder; U. Bärtsch; M. Müller; M. Zorn; P.P. Nawroth; T. Schilling
07/15/2013
Leptin; Leptin receptor; Polymorphism; Preeclampsia

The aim of this study was to investigate the relationship between the leptin receptor (LEPR) polymorphism/serum leptin level and preeclampsia. The prevalence of a single nucleotide polymorphism in the LEPR gene exon 14 at -656 and the serum leptin concentrations in 97 preeclamptic pregnant mothers were compared to those of 110 healthy controls. The Lys656Asn genotype and ... more

S. Wang; F.Y. Qiao; L. Feng
10/11/2012
Beef cattle; Bos indicus; Leptin; Molecular markers; Ultrasound traits

Given the important role of leptin in metabolism, we looked for a possible association of leptin and leptin receptor polymorphisms with carcass and growth traits in Nellore cattle. We examined associations of leptin and leptin receptor SNPs with ultrasound carcass (longissimus dorsi muscle area (ribeye area), backfat thickness and rump fat thickness and growth traits (weaning weight ... more

R.C.G. da Silva; J.B.S. Ferraz; F.V. Meirelles; J.P. Eler; J.C.C. Balieiro; D.C. Cucco; E.C. Mattos; F.M. Rezende; S.L. Silva
02/14/2014
Gene expression; Leptin; Leptin receptor; Swine

Leptin is an important regulator of appetite, energy metabolism, and reproduction and is mainly synthesized in the adipocytes and then secreted into the bloodstream. The leptin receptor was classified as type I cytokine receptor due to its structural homology with IL-6 receptors and the signaling pathways in which they are both involved. The aim of our study is to comparatively assess the ... more

S.E. Georgescu; M.A. Manea; S. Dinescu; M. Costache
02/14/2014
Adiponectin; Adult GHD; Leptin; Visfatin

We aimed to determine the significance and changes in leptin, adiponectin (ADP), and visfatin levels in adults with growth hormone deficiency (GHD). Forty adults (19 men, 21 women) who had been diagnosed with GHD comprised the observation group, while 36 healthy adults (18 men, 18 women) were used as the control group. Fasting venous blood was collected to detect leptin, ADP, and ... more

Z.P. Li; M. Zhang; J. Gao; G.Y. Zhou; S.Q. Li; Z.M. An
11/10/2009
Antibodies; Diabetes mellitus; HLA

To differentiate among different types of diabetes is becoming an increasingly challenging task. We investigated whether the patient’s genetic profile is useful to identify the particular type of diabetes, to determine the corresponding hyperglycemia pathogenesis and treat accordingly. Three hundred and thirty-eight diabetic patients, diagnosed according to American Diabetes Association ... more

A. Mimbacas; L. García; P. Zorrilla; M. Acosta; C. Airaudo; R. Ferrero; A. Pena; B. Simonelli; E. Soto; G. Vitarella; J. Fernandez; G. Javiel
11/29/2011
COX; Diabetes mellitus; MMP-9; NF-κB; Resveratrol; SIRT1

Resveratrol (RSV) has a beneficial role in the prevention of diabetes and alleviates some diabetic complications, such as cardiomyopathy. We investigated cyclooxygenase-1 (COX-1), COX-2, nuclear factor κB (NF-κB), matrix metalloproteinase-9 (MMP-9), and sirtuin 1 (SIRT1) mRNA expression levels in heart tissue after RSV treatment in streptozotocin (STZ)-induced diabetic rats. After ... more

A.S. Yar; S. Menevse; E. Alp
04/10/2015
Diabetes mellitus; GAD-Ab; Glutamic acid decarboxylase 2; Single nucleotide polymorphism

In this study, we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid de­carboxylase 2 (GAD2) 5'-untranslated region and the susceptibility to type 2 diabetes in the Han population. The distributions of patients with SNPs in the GAD2 5'-untranslated region ( ... more

Q. Li; Z.R. Qiao; D.B. Liu; J.T. Zeng; J. Zhang; Y. Bo; H.Y. Zu; Q. Hu; X. Wu; S.S. Dong
08/14/2015
Diabetes mellitus; experimental; MicroRNA profiling; Skin; Wound healing

Despite years of effort, current therapies for diabetic wounds are still not fully efficacious. Emerging evidence has suggested that microRNAs (miRNAs) play key roles in multiple physiological and pathological processes in eukaryotes, and could potentially be powerful therapeutic tools. This study investigated the differential expression profiling of miRNAs in cutaneous wounds in ... more

Y.F. Liu; M. Ding; D.W. Liu; Y. Liu; Y.G. Mao; Y. Peng
08/03/2015
Diabetes mellitus; Genetic susceptibility; Melatonin receptor; MT2; Pregnancy; Single nucleotide polymorphisms

We investigated the association between rs4753426 single nucleotide polymorphisms in the melatonin receptor 1B (MTNR1B) gene and the risk of developing gestational diabetes mellitus (GDM). A total of 516 gravidas (186 with GDM and 330 non-diabetic controls) were enrolled in the study. Genotype and allele frequencies of rs4753426 in the MTNR1B gene were detected by DNA ... more

Y. Zhan; C. Li; Q. Gao; J. Chen; S. Yu; S.G. Liu

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