Research Article

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Cyclin D1; Multiple myeloma; Single nucleotide polymorphism

Cyclin D1 is an important cell cycle regulator implicated in the pathogenesis of many cancer types. In particular, translocation and overexpression of cyclin D1 are common events in multiple myeloma (MM), suggesting that it may drive the initiation and progression of this malignancy. However, the association between genetic polymorphisms of cyclin D1 and the risk for developing MM remains ... more

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checkpoint; DNA repair; DNA replication; Proliferating cell nuclear antigen; Rad17/Mec3/Ddc1; Saccharomyces cerevisiae

DNA damage activates several mechanisms such as DNA repair and cell cycle checkpoints. The Saccharomyces cerevisiae heterotrimeric checkpoint clamp consisting of the Rad17, Mec3 and Ddc1 subunits is an early response factor to DNA damage and activates checkpoints. This complex is structurally similar to the proliferating cell nuclear antigen (PCNA), which serves as a sliding clamp ... more

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Adrenal cortex hormones; Corticosteroids; Dexamethasone; Glucocorticoid sensitivity inflammation; Nuclear factor kappa-B; Rheumatoid arthritis

We measured NF-κB, IKK, c-Fos, and GRαmRNA expression and in vivo glucocorticoid sensitivity in patients with rheumatoid arthritis. A very low dose intravenous dexamethasone suppression test and real-time PCR quantitation of mRNA of these genes were performed on blood samples from 21 rheumatoid arthritis patients who were not on glucocorticoids during the ... more

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cortisol; Dexamethasone; Glucocorticoid sensitivity; Systemic lupus erythematosus

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The secondary lymphoid tissue chemokine (CCL21) is closely associated with lymphoid homing and anti-tumor immune responses. CCL21 also has a chemotactic effect on intestinal lymphocytes. This study mainly focused on CCL21 expression in experimental ulcerative colitis and on the effects of CCL21 suppression on this disease in mice. The mouse colitis model was induced by dextran sulfate ... more

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Carcinogenesis; Cyclin D1; URG4

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Gene frequency; Human leukocyte antigen; Lung carcinoma

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Angiogenesis; Neural stem cells; Spinal cord injury

We examined the influence of neural stem cell transplantation on angiogenesis in rats with spinal cord injury. Sixty rats with spinal cord injury were divided into an experimental group and a control group and given neural stem cells or an equivalent amount of phosphate-buffered saline by intravenous transplantation, respectively. Basso, Beattie, and Bresnahan (BBB) motor function ... more

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