Research Article

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Clinical outcome; Hepatocellular carcinoma; Polymorphism; susceptibility; XPD; XRCC1

We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC). A total of 218 cases with HCC and 277 healthy controls were included in the study. Genotyping of the XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms was ... more

J.S. Wu; Y.P. Chen; L.C. Wang; Y.J. Yang; C.W. Deng; B.X. Hou; Z.L. He; J.X. Chen
02/28/2014
Hepatocellular carcinoma; Molecular marker; Risk factors; Single nucleotide polymorphisms; XRCC1

XRCC1 (human X-ray repair complementing defective repair in Chinese hamster cell 1) gene is considered a potentially important gene influencing the risk of hepatocellular carcinoma (HCC). Our analyses detected two allelic variants of XRCC1, c.910A>G and c.1686C>G. We aimed to investigate whether these polymorphisms influence the risk of HCC. The association between ... more

W.F. Xia; X.P. Ma; X.R. Li; H. Dong; J.L. Yi
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Hepatocellular carcinoma; Molecular marker; Single nucleotide polymorphism; susceptibility; XRCC1 gene

The human X-ray repair cross-complementing protein 1 (XRCC1) gene is a potentially gene determining hepatocellular carcinoma (HCC) susceptibility. The purpose of this study was to evaluate the association between XRCC1 and susceptibility to HCC. The association of XRCC1 polymorphisms with HCC susceptibility was investigated in 460 HCC patients and 463 controls ... more

X.F. Li; Y.X. Chen; W.W. Ye; X.F. Tao; J.H. Zhu; S. Wu; L.Q. Lou
05/18/2015
Cyclin D1 G870A; Hepatocellular carcinoma; Leukemia; Polymorphism; susceptibility

Cyclin D1 (CCND1) is a key protein involved in cell-cycle regulation, and the CCND1 G870A polymorphism is associated with many types of malignancy. Studies examining the associations between this G870A polymorphism and susceptibility to leukemia and hepatocellular carcinoma (HCC) have shown inconsistent results. Therefore, we conducted a meta-analysis to clarify these ... more

Y. Zhao; H.R. He; M.Y. Wang; X.D. Ren; L. Zhang; Y.L. Dong; J. Lu
11/17/2009
Genetic polymorphisms; Lipid profile; Marker assisted selection; Molecular markers; Nellore cattle; Single nucleotide polymorphisms
F.M. Rezende
10/07/2008
Brazilian population; Complement receptor-1; Duffy blood group; Genetic polymorphisms; Malaria; Toll-like receptor

The main purpose of this research was to analyze the relation of the genetic polymorphisms frequently expressed by antigen-presenting cells, erythrocytes and malaria susceptibility/resistance with the human malaria infection cases. The sample used consisted of 23 Plasmodium vivax (Pv)- and P. falciparum (Pf)-infected patients, and 21 healthy individuals as a control group, ... more

S.C. Soares; K. Abé-Sandes; V.B.Nascimento Filho; F.M.F. Nunes; W.A. Silva
06/15/2010
AGER; Genetic polymorphisms; Gestational diabetes; RAGE; Single nucleotide polymorphisms

The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have pro-inflammatory actions in human gestational tissues, ... more

I.C.R. Santos; D.R. Daga; H.R. Frigeri; R.R. Réa; A.C.R. Almeida; E.M. Souza; F.O. Pedrosa; C.M.T. Fadel-Picheth; G. Picheth
03/23/2010
Genetic polymorphisms; Glioma; Gluthatione S-transferase

The glutathione S-transferases (GSTs), a family of phase II isozymes, detoxify several carcinogens. Genetic variations in GSTs have been associated with increased risk for cancer due to a heritable deficiency in detoxification pathways for environmental carcinogens. Conflicting findings have been reported about the association between constitutive GST polymorphisms and gliomas in ... more

P. Coutinho; V. Sandim; J.A. Oliveira; G. Alves; A. Hatagima
01/12/2010
Association study; CYP27B1; EDN1; Genetic polymorphisms; GSTP1; Sarcoidosis

Sarcoidosis is a chronic inflammatory disease, characterized by granulomatous inflammation, prominently involving the respiratory system. The etiology of this disease has not yet been elucidated and the contribution of genetic is not yet completely understood. We searched for novel candidate genes, utilizing a system biology approach, based on data from published transcriptional, ... more

A. Maver; I. Medica; B. Salobir; M. Tercelj; B. Peterlin
12/16/2013
Allelic frequency; Genetic polymorphisms; Hemoglobin S; PCR-RFLP; Sickle cell disease; SNPs

Sickle cell anemia is an affection that causes chronic inflammation, with consequences for vaso-occlusion, oxidative stress and cytokine production. Genetic polymorphisms in markers involved in this process can modulate the inflammatory response, including polymorphisms -308G/A of TNFA (tumor necrosis factor alpha) and -509C/T of TGFB1 (transforming growth factor beta 1), reported to ... more

L.S. Torres; B. Júnior; D.G. Silva; C.L. Lobo; M.A. Ruiz; C.R. Bonini-Domingos

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