Research Article

Related GMR Articles

06/15/2012
Genetic polymorphisms; Meta-analysis; Prostate cancer; PTGS2

Evidence is accumulating that chronic inflammation has an important role in prostate cancer. Two common polymorphisms in the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, rs20417 and rs689470, have been found to alter the risk for prostate cancer, but the various studies are not in agreement. To derive a more precise estimation of this association, all available studies were ... more

H.T. Zhang; Y. Xu; Z.H. Zhang; L. Li
11/29/2011
Gene polymorphism; Meta-analysis; p53 codon 72; Prostate cancer

We examined whether p53 codon 72 polymorphism confers prostate cancer risk by conducting a meta-analysis. Two investigators independently searched the Pubmed, Embase and CBM databases. This meta-analysis was made of seven case-control studies, that included 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on all the studies showed no significant association ... more

M.S. Li; J.L. Liu; Y. Wu; P. Wang; H. Teng
02/28/2013
Asian; Caspase 8; Genetic polymorphisms; Meta-analysis; Neoplasm

Genetic variation in the CASP-8 gene reportedly can increase cancer susceptibility by regulating tumor cell proliferation and apoptosis. Several studies have investigated this possibility; however, the conclusions remain controversial. We made a Human Genome Epidemiology (HuGE) review and did a meta-analysis to explore the association between CASP-8 gene polymorphisms and cancer risk in ... more

Y.J. Zhang; X.P. Zhong; Y. Chen; S.R. Liu; G. Wu; Y.F. Liu
12/14/2011
Gene set enrichment analysis; Meta-analysis; Prostate cancer

Prostate cancer is one of the most common male malignant neoplasms; however, its causes are not completely understood. A few recent studies have used gene expression profiling of prostate cancer to identify differentially expressed genes and possible relevant pathways. However, few studies have examined the genetic mechanics of prostate cancer at the pathway level to search for such ... more

Q.Y. Ning; J.Z. Wu; N. Zang; J. Liang; Y.L. Hu; Z.N. Mo
11/17/2009
Genetic polymorphisms; Lipid profile; Marker assisted selection; Molecular markers; Nellore cattle; Single nucleotide polymorphisms
F.M. Rezende
10/07/2008
Brazilian population; Complement receptor-1; Duffy blood group; Genetic polymorphisms; Malaria; Toll-like receptor

The main purpose of this research was to analyze the relation of the genetic polymorphisms frequently expressed by antigen-presenting cells, erythrocytes and malaria susceptibility/resistance with the human malaria infection cases. The sample used consisted of 23 Plasmodium vivax (Pv)- and P. falciparum (Pf)-infected patients, and 21 healthy individuals as a control group, ... more

S.C. Soares; K. Abé-Sandes; V.B.Nascimento Filho; F.M.F. Nunes; W.A. Silva
06/15/2010
AGER; Genetic polymorphisms; Gestational diabetes; RAGE; Single nucleotide polymorphisms

The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have pro-inflammatory actions in human gestational tissues, ... more

I.C.R. Santos; D.R. Daga; H.R. Frigeri; R.R. Réa; A.C.R. Almeida; E.M. Souza; F.O. Pedrosa; C.M.T. Fadel-Picheth; G. Picheth
03/23/2010
Genetic polymorphisms; Glioma; Gluthatione S-transferase

The glutathione S-transferases (GSTs), a family of phase II isozymes, detoxify several carcinogens. Genetic variations in GSTs have been associated with increased risk for cancer due to a heritable deficiency in detoxification pathways for environmental carcinogens. Conflicting findings have been reported about the association between constitutive GST polymorphisms and gliomas in ... more

P. Coutinho; V. Sandim; J.A. Oliveira; G. Alves; A. Hatagima
01/12/2010
Association study; CYP27B1; EDN1; Genetic polymorphisms; GSTP1; Sarcoidosis

Sarcoidosis is a chronic inflammatory disease, characterized by granulomatous inflammation, prominently involving the respiratory system. The etiology of this disease has not yet been elucidated and the contribution of genetic is not yet completely understood. We searched for novel candidate genes, utilizing a system biology approach, based on data from published transcriptional, ... more

A. Maver; I. Medica; B. Salobir; M. Tercelj; B. Peterlin
12/16/2013
Allelic frequency; Genetic polymorphisms; Hemoglobin S; PCR-RFLP; Sickle cell disease; SNPs

Sickle cell anemia is an affection that causes chronic inflammation, with consequences for vaso-occlusion, oxidative stress and cytokine production. Genetic polymorphisms in markers involved in this process can modulate the inflammatory response, including polymorphisms -308G/A of TNFA (tumor necrosis factor alpha) and -509C/T of TGFB1 (transforming growth factor beta 1), reported to ... more

L.S. Torres; B. Júnior; D.G. Silva; C.L. Lobo; M.A. Ruiz; C.R. Bonini-Domingos

Pages