Research Article

Related GMR Articles

Angiogenesis; bFGF; c-Myc; Gastric cancer; Recombinant human endostatin; Tumor metastasis

The aim of this study was to observe the effects of re­combinant human endostatin on the proliferation and apoptosis of mouse gastric cancer cells, and explore some possible mechanisms of recom­binant human endostatin inhibition of cancer. A murine gastric cancer xenograft model was established. A total of 20 mice were divided into two groups (control and experimental groups). The ... more

Z.Y. Guo; G.D. Yao; L.P. Fu; Z.G. Fu; B. Hou
Cauda equina lesions; Cerebrospinal fluid; Ganglia; Neonatal dorsal root; Neural stem cells; Transplantation

Cauda equina syndrome (CES) is characterized by varying patterns of low back pain, sciatica, lower extremity sensorimotor loss, and bowel and bladder dysfunction. The prognosis for complete recovery of CES is dependent on not only the time before surgical intervention with decompression but also the severity of the nerve damage. Delayed or severe nerve compression impairs the capability ... more

Z.Y. Fu; J.G. Shi; N. Liu; L.S. Jia; W. Yuan; Y. Wang
DNA damage; Huwe1; Neural stem cells; Notch signaling

The ubiquitin-proteasome system (UPS) regulates many cellular processes, including protein stability, cell cycle control, DNA repair, transcription, signal transduction, and protein trafficking. In fact, UPS plays a key role in various stress conditions such as ischemia, glutamate toxicity, Alzheimer’s disease, and Parkinson’s disease. Huwe1, a homologous to E6-AP carboxy terminus (HECT) ... more

J. Zhou; Q. Liu; M. Mao; Y. Tong
Axon regeneration; Cell transplantation; Erythropoietin; Neural stem cells; Spinal cord injury

We investigated the effect of neural stem cells (NSC) and erythropoietin (EPO) on axon regeneration in adult rats with transected spinal cord injury, and provided an experimental basis for clinical treatment. Forty Wistar rats with T10-transected spinal cord injury were randomly divided into four groups of ten rats: a control group (group A), an NSC-transplant group (group B), an NSC- ... more

Y. Zhao; Y. Zuo; X.L. Wang; H.J. Huo; J.M. Jiang; H.B. Yan; Y.L. Xiao
Angiogenesis; Cyclin D1; Dexamethasone; HIF-1α; Lung carcinoma; Proliferating cell nuclear antigen

Recent studies have found that glucocorticoids are closely associated with oncogenesis and the development of many types of tumors. The aim of this study was to observe the effect of dexamethasone on the growth and angiogenesis of transplanted Lewis lung carcinoma in mice. Lewis lung carcinoma cells were inoculated subcutaneously into the right axilla of C57BL/6 mice, and the mice were ... more

Y. Geng; J. Wang; H. Jing; H.W. Wang; Y.X. Bao
Anaphase promoting complex; Lentivirus; RNAi; Spinal cord injury

This study investigated cadherin-1 (Cdh1) expression in the sensorimotor cortex of rats after spinal cord injury (SCI). The repairing effect of Cdh1 was evaluated by silencing its expression with lentivirus-mediated RNAi. Twenty male Sprague-Dawley (SD) rats were randomly divided into a normal group and an operation group. Rats of the operation group were given SCI by the Allen method ( ... more

Y.H. Qi; W.L. Yao; C.H. Zhang; Y.Q. Guo
Interleukin-10; Musk ketone; Nerve function; Spinal cord injury

The present study aimed to determine the effects of musk ketone on nerve recovery in rats after spinal cord injury. A total of 105 SD female rats were used to establish the rat with dorsal spinal cord injury model (modified Allen’s method). The rats weighed from 200 to 250 g and were provided by the Experimental Animal Center of Chongqing Medical University. They were randomly divided ... more

L. Guo; Z.X. Quan; Z.H. Zhao; K. Tang; Y.S. Ou; D.M. Jiang
Free radical; Nimodipine; Peroxidase; Propylene glycol; Rats; Spinal cord injury

We evaluated the potentially protective effect of nimodipine on rat spinal cord injury. Sprague-Dawley rats received spinal cord injury, and were separated into nimodipine (N = 12) and saline groups (N = 12). Within 1 h of the injury, rats were treated intraperitoneally with nimodipine (1.0 mg/kg) or an equal amount of saline. Treatment was performed 3 times a day for 1 week. Operation ... more

Y.F. Jia; H.L. Gao; L.J. Ma; J. Li