Research Article

Related GMR Articles

12/08/2011
Diabetic retinopathy; Single nucleotide polymorphism; Type 2 diabetes

Retinoid-X receptor (RXR) is one of the members of the nuclear hormone receptor superfamily. It forms heterodimers with many nuclear receptors, such as the peroxisome proliferative-activated receptor, which has been proposed to be involved in diabetic complications, including retinopathy. A recent study revealed that RXR-alpha has antioxidant properties and is associated with diabetic ... more

C.H. Hsieh; D. Pei; Y.J. Hung; F.C. Hsiao
05/22/2015
Atorvastatin; Diabetic retinopathy; Vascular endothelial growth factor; Vascular endothelial growth inhibitor; Wistar rats

We investigated the effect of atorvastatin on vascular endothelial growth inhibitor (VEGI) expression in rats with diabetic retinopathy. Wistar rats were divided into a blank group and diabetic model group, which was further randomly divided into treatment and control groups. Rats in the treatment group received 10 mg/kg atorvastatin daily, while rats in the blank and control groups received ... more

M.C. Bi; X.J. Song; H. Shi; W.X. Xue; C.L. Xu; E. Song
04/25/2016
Diabetic retinopathy; Retinal ganglion cells; TLR-4; Toll-like receptor-2

Diabetic retinopathy (DR), a major complication of diabetes mellitus, is the leading cause of adult blindness. The Toll-like receptor (TLR) family is believed to be involved in the pathogenesis and progression of DR. Here, we investigated the expression profiles of TLR-2 and TLR-4 in retinal ganglion cells (RGCs), in an attempt to elucidate the role of these molecules in the etiology of ... more

M. Zhao; C.H. Li; Y.L. Liu; M. Zhao; C.H. Li; Y.L. Liu; M. Zhao; C.H. Li; Y.L. Liu
06/10/2016
Diabetic retinopathy; Epigallocatechin-3-gallate; Human retinal endothelial cell

Diabetic retinopathy (DR) is a frequent microvascular complication of diabetes, and one of the most common causes of legal blindness in the world. Epigallocatechin-3-gallate (EGCG) produces an anti-oxidative and anti-inflammatory effect against various human diseases. In this study, we determined the effect of EGCG on a human retinal endothelial cell (HREC) line. The cell viability was ... more

L. Zhang; Z.K. Zhang; S. Liang; L. Zhang; Z.K. Zhang; S. Liang
05/13/2016
Diabetic retinopathy; Inflammatory cytokines; Ozone treatment; VEGF

The aim of this study was to investigate the effect of ozone on inflammatory cytokines in diabetic retinopathy (DR) rats. Male rats (40) weighing 300-360 g were included in this study. Thirty rats were randomly divided into the model and ozone groups after DR was induced by streptozotocin. Ten rats served as the blank group. After the diabetic models were established for one month, the ... more

T.Y. Xie; W. Yan; J. Lou; X.Y. Chen; T.Y. Xie; W. Yan; J. Lou; X.Y. Chen
07/15/2016
Diabetic retinopathy; Th1; Th2

Diabetic retinopathy (DR), an important complication of diabetes mellitus (DM), is not well understood. T helper cell balance (Th1/Th2) is involved in various autoimmune diseases; however, its role in DR is not understood. This study explores changes in Th1 and Th2 cytokine expression during DR. Blood samples were collected from 25 healthy volunteers (normal control group), 35 patients ... more

Y.L. Cao; F.Q. Zhang; F.Q. Hao; Y.L. Cao; F.Q. Zhang; F.Q. Hao
02/13/2014
Asthma; COPD; Meta-analysis; Systematic review; Vitamin D deficiency; Vitamin D insufficiency

Vitamin D deficiency and insufficiency are increasingly being recognized in the general population over the last few decades. However, a number of other disorders have now been linked to vitamin D deficiency and insufficiency, including asthma and COPD. The aim of this study was to evaluate the evidence on the effect of vitamin D on asthma and COPD. We searched electronic databases ... more

L.L. Zhang; J. Gong; C.T. Liu
10/19/2010
IL-6; Insulin resistance; SNP; TCF7L2; TNF; VDR

A population-based study was undertaken to evaluate linkage between single-nucleotide polymorphisms known as risk factors and type 2 diabetes in an Indian population. The study population was comprised of 40 normal glucose-tolerant individuals (21 males and 19 females) and 40 type 2 diabetes patients (21 males and 19 females). The genes and their corresponding single-nucleotide ... more

P.N. Mukhopadhyaya; A. Acharya; Y. Chavan; S.S. Purohit; A. Mutha
12/04/2013
Breast cancer; POU5F1P1; PTPN13; TCF7L2

Recent genome wide association studies (GWAS) and candidate gene studies have revealed many novel loci associated with colorectal cancer susceptibility. We evaluated the effect of these colorectal cancer-associated variants on the risk of breast cancer in a Chinese Han population. Seven single nucleotide polymorphisms (SNPs) (rs3856806 in PPARG, rs7014346 in POU5F1P1, ... more

W. Wei; M. Jiang; L. Luo; Z. Li; P. Wang; W.Q. Dong
09/29/2014
Genetic polymorphisms; Mixed population; rs12255372; rs7903146; TCF7L2; Type 2 diabetes

Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have demonstrated a strong association of two polymorphic variations in ... more

C.M.A.R. Barros; A.P. Araújo-Neto; T.R. Lopes; M.A.L. Barros; F.J.N. Motta; R. Canalle; L.C.C. Nunes; J.A. Rey; R.R. Burbano; M.A. Lima-Barros; F.K.N. Yoshioka; G.R. Pinto

Pages