Research Article

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10/31/2014
Breast cancer; Folate; MTHFR; Polymorphism; Vitamin

We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vitamin B12 levels were ... more

J.M. He; Y.D. Pu; Y.J. Wu; R. Qin; Q.J. Zhang; Y.S. Sun; W.W. Zheng; L.P. Chen
10/29/2013
Folate; Glioma; MGMT; MTHFR; Polymorphisms

Hypomethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter in glioma cells has been associated with temozolomide resistance. S-adenosylmethionine (SAM), which is produced during folate metabolism, is the main source of methyl groups during DNA methylation. As a key enzyme during folate metabolism, polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) may ... more

N. Liu; J. Jiang; Y.J. Song; S.G. Zhao; Z.G. Tong; H.S. Song; H. Wu; J.Y. Zhu; Y.H. Gu; Y. Sun; W. Hua; J.P. Qi
02/19/2008
Breast cancer; Chemotherapy; P-glycoprotein; Polymorphism

Primary chemotherapy is a useful strategy for the treatment of locally advanced breast cancer and therefore allows in vivo evaluation of the action of cytotoxic drugs and the possibility of accomplishing conservative breast surgeries, as well as the early treatment of metastasis. Mechanisms of resistance to the drugs include the action of protein associated with the efflux of drugs from ... more

F.F.O. Rodrigues; R.E. Santos; M.B. Melo; M.A.L.G. Silva; A.L. Oliveira; R.L. Rozenowicz; L.B. Ulson; T. Aoki
12/08/2011
Breast cancer; CYP2C19; Genetics; Polymorphism

Cytochrome P450 (CYP) 2C19 metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids, which significantly promote proliferation of cancer cells in vitro and in vivo. We looked for a possible association between human CYP2C19*3 gene polymorphism and breast cancer in the Chinese Han population. In a Chinese Han case-control study of breast cancer ... more

C.Q. Gan; X.Y. Wang; Y.D. Cao; W.X. Ye; H. Liu; Y.Y. Sun
06/21/2011
Colorectal cancer; Kashmir; MTHFR; Polymorphism; Restriction digestion; RFLP

Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism has been widely investigated in different cancers and has been ... more

A.S. Sameer; Z.A. Shah; S. Nissar; S. Mudassar; M.A. Siddiqi
08/31/2010
Breast cancer; D‑loop; mtDNA; Polymorphism

A high incidence of somatic mtDNA polymorphisms has been reported in a wide variety of human cancers; some of them have been proposed as markers for the early detection of breast cancer. However, little attention has been paid to the potential of germline mitochondrial sequence variations as genetic risk factors for cancer. We performed a case-control study of 70 unrelated Tunisian women ... more

Y. Loueslati; W. Troudi; L. Cherni; K.B. Rhomdhane; L. Mota-Vieira
06/11/2010
Breast cancer; Drug therapy; Genetic; Glutathione transferase; Polymorphism

The glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione. We examined whether GSTT1/GSTT1“null”, GSTM1/GSTM1“null” and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associated with different response rates to neoadjuvant ... more

A.L. Oliveira; F.F.O. Rodrigues; R.E. Santos; T. Aoki; M.N. Rocha; C.A. Longui; M.B. Melo
09/12/2014
Breast cancer; EPHX1; Lung cancer; Meta-analysis; Polymorphism

The association between the microsomal epoxide hydrolase 1 gene (EPHX1) Tyr113His polymorphism and lung cancer and breast cancer risk has been reported in many recent studies, but there is no consensus among the results. Thus, we examined the association between the EPHX1 Tyr113His polymorphism and lung cancer through a meta-analysis. A comprehensive literature search was ... more

X. Tan; Y.Y. Wang; X.Y. Chen; L. Xian; J.J. Guo; G.B. Liang; M.W. Chen
01/22/2014
Breast cancer; Drug therapy; Genetic; Glutathione transferase; Polymorphism

The glutathione S-transferase (GST) family comprises phase-II cellular detoxification enzymes that catalyze the conjugation of chemotherapy drugs to glutathione and act on the apoptotic pathway. The aim of this study was to determine whether polymorphisms of the GSTT1, GSTM1, and GSTP1 genes are associated with different rates of overall survival (OS) and disease ... more

A.L. Oliveira; F.F.Oliveira Rodrigues; R.Edos Santos; R.L. Rozenowicz; B. de Melo
06/11/2015
Breast cancer; MicroRNA; Polymorphism

Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide polymorphisms (mir-499 rs3746444 A> ... more

P. Qi; L. Wang; B. Zhou; W.J. Yao; S. Xu; Y. Zhou; Z.B. Xie

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