Research Article

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11/08/2011
Gene polymorphism; Liver cirrhosis; Meta-analysis; Risk; Tumor necrosis factor

TNF-α is a potential proinflammatory cytokine that plays an important role in the pathogenesis of liver cirrhosis. We investigated a possible association between TNF-α -308G>A polymorphism and liver cirrhosis risk by conducting a meta-analysis. Publications addressing the association between TNF-α -308G>A and liver cirrhosis risk were selected from the Pubmed and Embase databases. ... more

D. Chen; J.L. Liu; Y. Liu; J. Zhu; S.W. Wang
12/08/2011
Corneodesmosin; Gene polymorphism; Meta-analysis; Psoriasis; Risk

Previous studies investigating the association between corneodesmosin (CDSN) polymorphisms and psoriasis risk have provided inconsistent results. The aim of our study was to clarify the effects of CDSN -619C/T polymorphism on psoriasis risk by conducting a meta-analysis. We conducted searches of the published literature in Pubmed and Embase databases up to October 2010. Six studies with a ... more

Y. Wu; B. Wang; J.L. Liu; X.H. Gao; H.D. Chen; Y.H. Li
12/02/2011
Gene polymorphism; Glutathione peroxidase 1; Keshan disease; Selenium

Keshan disease (KD) is an endemic cardiomyopathy associated with selenium deficiency. Recent studies indicate that glutathione peroxidase 1 (GPx1) mutation decreases GPx activity in myocardial cells and increases the risk of KD. To further clarify the correlation between GPx1 polymorphism and KD, we analyzed GPx1 polymorphism, blood selenium levels and GPx activity in KD patients and ... more

H.L. Wei; J.R. Pei; C.X. Jiang; L.W. Zhou; T. Lan; M. Liu; T. Wang
11/29/2011
Gene polymorphism; Meta-analysis; p53 codon 72; Prostate cancer

We examined whether p53 codon 72 polymorphism confers prostate cancer risk by conducting a meta-analysis. Two investigators independently searched the Pubmed, Embase and CBM databases. This meta-analysis was made of seven case-control studies, that included 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on all the studies showed no significant association ... more

M.S. Li; J.L. Liu; Y. Wu; P. Wang; H. Teng
05/24/2011
ClC-Kb; Essential hypertension; Gene polymorphism; Mongolian population; SLC12A3

Abnormalities in renal sodium chloride and water reabsorption play important roles in the development of hypertension. Mutations in the genes involved in renal sodium chloride reabsorption can affect blood pressure. Recently, the R904Q variant of the sodium/chloride transporters, member 3 (SLC12A3) gene and the T481S variant of the chloride channel Kb (ClC-Kb) gene were found to be implicated ... more

P.Y. Chang; X.G. Zhang; X.L. Su
08/31/2010
Dairy Holstein; Gene polymorphism; IGF-I; Milk fat; Milk protein

We estimated the allele and genotype frequencies of IGF-I/SnaBI gene polymorphism and the concentration of this protein in Holstein dairy cows. We also examined the association with milk yield (305-day milk yield) and milk components (fat and protein percentage, and 305-day milk protein and fat yield). Blood IGF-I levels were measured and genotyping was performed on 250 Holstein ... more

E. Bonakdar; H.R. Rahmani; M.A. Edriss; B.E.Sayed Tabatabaei
08/17/2010
Bladder cancer; Gene polymorphism; Meta-analysis; p53 codon 72

Although there have been many studies investigating a possible association between p53 codon 72 polymorphism and risk of bladder cancer, the results have been inconsistent. We conducted a meta-analysis of six epidemiological studies, which included 597 bladder cancer cases and 731 controls. Patients with bladder cancer had a significantly lower frequency of Pro/Arg [odds ratio (OR) = 0.80 ... more

D.B. Li; X. Wei; L.H. Jiang; Y. Wang; F. Xu
12/04/2013
Congenital heart defects; Gene polymorphism; Meta-analysis; Methylenetetrahydrofolate reductase

Numerous studies have evaluated the association between the maternal C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and congenital heart defect (CHD) risk in the Chinese Han population. However, the specific association is still controversial. Six separate studies with 1089 subjects in the Chinese Han population on the relationship between the C677T ... more

K.H. Chen; L.L. Chen; W.G. Li; Y. Fang; G.Y. Huang
11/26/2013
Allele; Endometrium; Estrogen receptor; Gene polymorphism

The aim of this study was to investigate the potential correlation between polymorphisms of the estrogen receptor (ER)-β gene (RsaI and AluI) and ethnic Han Chinese human idiopathic thin endometrium. A total of 120 patients with idiopathic thin endometrium and 120 sterility patients with normal endometrium thickness (controls) were included in the study. RsaI and ... more

A.W. Le; Z.H. Wang; R. Yuan; L.L. Shan; T.H. Xiao; R. Zhuo; Y. Shen
10/30/2013
Carotid artery atherosclerotic disease; Essential hypertension; Gene polymorphism; Paraoxonase (PON)

We investigated the relationships between paraoxonase genetic polymorphisms and essential hypertension in carotid artery atherosclerotic patients. The study included 353 Han participants and 240 Uighur participants from Xinjiang; they were further divided into two groups: essential hypertension with carotid artery atherosclerosis (CAAD group) and essential hypertension without carotid ... more

L. Han; X.J. Xu; X.H. Liang; J. Ma

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