Research Article

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04/27/2015
Color Doppler ultrasound; Lower extremity vasculopathy; Risk factors; Type 2 diabetes

This study aims to investigate the value of high-resolution color Doppler ultrasonography (HR-CDU) in the evaluation of lower-extremity vasculopathy (LEV) and its related risk factors in type 2 diabetes mellitus (T2DM) patients. Two hundred forty T2DM patients were selected, who underwent lower-extremity arterial HR-CDU. The patients were divided into the LEV group (V group) and the ... more

J. Xu; G. Wang; D. Fu; N. Su; L. Wang; F. Gao; N. Guo
02/17/2012
Animal model; Brain; Energy metabolism; Ethanol; Extended amygdala

We examined a possible relationship between genes responsible for energy metabolism of the brain and addictive behavior in an animal model. We used non-inbred, Swiss mice exposed to a three-bottle free-choice model [water, 5% (v/v) ethanol, and 10% (v/v) ethanol] over a 16-week period, consisting of four phases: acquisition, withdrawal, reexposure, and quinine-adulteration. The mice were ... more

A.F. Ribeiro; D. Correia; R. Boerngen-Lacerda; A.L. Brunialti-Godard
03/23/2010
Genoplot image; Oligonucleotide microarray; Positional effects; Probe-target sequence

Single nucleotide polymorphisms (SNPs) present in probe-target sequences (SPTS) have been shown to be associated with abnormal genoplot images. We explored the effects of SPTS positions on genoplot images using a data set from a genome-wide association study typed on an Illumina Human Hap300 platform. We screened the physical genomic positions of 308,330 autosomal probes to identify SPTS ... more

T.L. Cui; H. Nakaoka; K. Akiyama; H. Kamura; K. Hosomichi; J. Bae; H. Cheong; H. Shin; T. Yada; I. Inoue
06/15/2010
CDKAL1; Meta-analysis; Single nucleotide polymorphism; Type 2 diabetes

CDKAL1 (cyckin-dependent kinase 5 regulatory subunit-associated protein 1-like 1) has been shown to be associated with type 2 diabetes in various ethnic groups; however, contradictory results have been reported. We performed a comprehensive meta-analysis of 21 studies for rs7756992, 17 studies for rs7754840 and 10 studies for rs10946398 variants of the CDKAL1 gene to ... more

M.A.S. Dehwah; M. Wang; Q.Y. Huang
09/03/2013
Association study; Meta-analysis; Type 2 diabetes; UCP2

Uncoupling protein 2 (UCP2) is a mitochondrial transporter protein and can affect the function of β-cells. We investigated a possible association between functional UCP2 -866G/A and Ala55Val polymorphisms and type 2 diabetes in 715 Hubei Han Chinese. No significant association was found, either for the -866G/A polymorphism (allele, P = 0.254; genotype, P = 0.508) or for the ... more

L.J. Qin; J. Wen; Y.L. Qu; Q.Y. Huang
08/20/2013
ABCC8; KCNJ11; Meta-analysis; miRNA; Type 2 diabetes

KCNJ11 (potassium inwardly rectifying channel, subfamily J, member 11) and ABCC8 (ATP-binding cassette, subfamily C (CFTR/MRP), member 8) have been studied for association with type 2 diabetes in various ethnic populations with contradictory results. We performed a comprehensive meta-analysis for KCNJ11 rs5219, rs5210, rs5215, and ABCC8 rs757110 to ... more

L.J. Qin; Y. Lv; Q.Y. Huang
01/24/2014
Blood glucose; Elderly; Gastric emptying; Rehabilitation management; Type 2 diabetes

The relationship between gastric emptying dysfunction and blood glucose concentration in elderly with type 2 diabetes mellitus was investigated, and the effect of rehabilitation exercise prescription training on gastric emptying in the geriatric diabetic patients was evaluated. A total of 160 older type 2 diabetic adults and 30 cases of non-diabetic patients were studied with regard to ... more

Z.M. Shao; J.F. Yao; J. Chen; Z.W. Yu; X.F. Yu; J.J. Zheng; X. Tang
09/29/2014
Genetic polymorphisms; Mixed population; rs12255372; rs7903146; TCF7L2; Type 2 diabetes

Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have demonstrated a strong association of two polymorphic variations in ... more

C.M.A.R. Barros; A.P. Araújo-Neto; T.R. Lopes; M.A.L. Barros; F.J.N. Motta; R. Canalle; L.C.C. Nunes; J.A. Rey; R.R. Burbano; M.A. Lima-Barros; F.K.N. Yoshioka; G.R. Pinto
03/27/2015
CAPN10 polymorphisms; Mexican mestizo; Type 2 diabetes

The calpain-10 gene is expressed primarily in tissues important in glucose metabolism; thus, some of its polymorphisms have been associated with type 2 diabetes. In this study, we examined the association between the calpain-10 single-nucleotide polymorphism (SNP)-43, SNP-19, and SNP-63 and type 2 diabetes in Mexican mestizos. We included 211 patients and 152 non-diabetic subjects. ... more

V.J. Picos-Cárdenas; E. Sáinz-González; A. Miliar-García; A. Romero-Zazueta; R. Quintero-Osuna; E. Leal-Ugarte; V. Peralta-Leal; J.P. Meza-Espinoza

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