Related GMR Articles
The effects of high glucose on the expression of monocyte chemoattractant protein-1 (MCP-1) and the main component of the extracellular matrix, fibronectin (FN), were explored in human mesangial cells (HMCs), along with the intervention effects of mycophenolate mofetil (MMF) on these indicators. Cultured HMCs were divided into five groups: 1) normal control group (5 mM glucose); 2) high ... more
We explored the associations of INSR and mTOR, 2 key genes in the insulin signaling pathway, and the susceptibility to type 2 diabetes mellitus and diabetic nephropathy. Three single-nucleotide polymorphisms (SNPs) (rs1799817, rs1051690, and rs2059806) in INSR and 3 SNPs (rs7211818, rs7212142, and rs9674559) in mTOR were genotyped using the Sequenom ... more
This study aimed to investigate the expression levels of the Raf kinase inhibitor protein (RKIP) and NF-κB in renal tissues of diabetic nephropathy (DN) rats, and to determine the underlying molecular targets of rituximab (RTX), with the goal of developing new clinical treatment selection for DN. Sprague-Dawley rats were randomly divided into a normal group (N), a DN group (M), and an ... more
The aims of this study were to explore the effects of Astragaloside IV on diabetic nephropathy (DN) rats. A total of 38 male Sprague-Dawley (SD) rats were divided into three groups: 10 in the normal (control) group, 14 in the DN model group, and 14 in the AS-IV group. Treatment began one week after the streptozotocin DN model was successfully established. Blood glucose and urine micro- ... more
We explored the correlation between serum YKL-40 levels and albuminuria in type 2 diabetes mellitus (T2DM) and its clinical significance. This study used a cross-sectional survey method. According to the American Diabetes Association 2007 Clinical Practice Recommendations, 738 patients with T2DM were divided into three groups: a normoalbuminuria group [albumin-to-creatinine ratio (ACR) ... more
We examined the correlation between gene polymorphisms in hypoxia-inducible factor-1α (HIF-1α) Pro582Ser and type 2 diabetic nephropathy (DN). A total of 244 subjects with type 2 diabetes were recruited. The 1285-bp locus polymorphism of HIF-1α exon was detected using polymerase chain reaction-restriction fragment length polymorphism. C/T single nucleotide polymorphisms were detected at ... more
Retinol-binding protein 4 (RBP4) is a novel adipokine that has been associated with insulin resistance and type 2 diabetes. Patients with end-stage renal disease (ESRD) have very high serum RBP4 levels. However, whether successful kidney transplantation alleviates these elevated serum RBP4 levels is unclear. The serum RBP4 levels of 24 ESRD patients were determined before transplantation ... more
This study was designed to analyze the relationship between serum creatinine and body mass index in children in Xinjiang, China. We used a stratified sampling method to select 5222 children aged 6-17 years in 3 areas in Xinjiang and then measured serum creatinine with an enzymatic method. Our analysis showed that the mean serum creatinine of the various age groups differed, and the ... more
We evaluated the initial results of laparoscopic partial nephrectomy (LPN) in the treatment of renal tumors in Thanh Hoa General Hospital. During examination, 10 patients (6 females, 4 males) were diagnosed with renal tumors on CT scans. Later they underwent LPN at Thanh Hoa General Hospital from November 2016 to March 2018. The mean age was 54.5 years. Average ... more
We evaluated the results of laparoscopic nephrectomy for the treatment of renal tumors in a provincial hospital. Subjects and methods: 30 patients were diagnosed with renal tumors and underwent laparoscopic nephrectomy at a General Hospital, in Vietnam. The mean age was 53.23 years, the rate of incidental detection of tumors was 8/30. Average ... more