Research Article

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Anticancer activity of Bombyx batryticatus ethanol extract (BBE) against HeLa cells was studied using cell viability, DNA fragmentation, real-time polymerase chain reaction, and Western blot analyses. The BBE inhibited the growth and induced apoptosis of HeLa cells. The MTT assay indicated that the BBE induced cytotoxicity in HeLa cells in a time- and concentration-dependent ... more

W.P. Wu; J. Cao; J.Y. Wu; H. Chen; D. Wang
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Bioinformatics; Cancer; Expressed sequence tags; Gene discovery; ORESTES

The Human Cancer Genome Project generated about 1 million expressed sequence tags by the ORESTES method, principally with the aim of obtaining data from cancer. Of this total, 341,680 showed no similarity with sequences in the public transcript databases, referred to as “no-match”. Some of them represent low abundance or difficult to detect human transcripts, but part of these ... more

Rda Silva Fonseca; D.Maria Carraro; H. Brentani
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Cancer; CDH1 expression; Neuroepithelial tumors; Real-time polymerase chain reaction

Cadherins are cell-to-cell adhesion molecules that play an important role in the establishment of adherent-type junctions by mediating calcium-dependent cellular interactions. The CDH1 gene encodes the transmembrane glycoprotein E-cadherin which is important in maintaining homophilic cell-cell adhesion in epithelial tissues. E-cadherin interacts with catenin proteins to maintain ... more

F.J.N. Motta; E.T. Valera; A.K.B. Lucio-Eterovic; R.G.P. Queiroz; L. Neder; C.A. Scrideli; H.R. Machado; C.G. Carlotti-Junior; S.K.N. Marie; L.G. Tone
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Cancer; Gene network; Nucleotide excision repair; sporadic solid tumors

In general, stochastic tumors show genomic instability associated with the proliferation of DNA point mutations, that is, a mutator phenotype. This feature cannot be explained by a dysfunctional mismatch repair alone, and indicates that nucleotide excision repair (NER) and/or base excision repair should be suppressed. However, mutations in NER genes are not causally implicated in the ... more

J.C.M. Mombach; M.A.A. Castro; J.C.F. Moreira; R.M.C. de Almeida
09/23/2013
Cancer; Meta-analysis; MiR-499; Polymorphism

An A/G polymorphism (rs3746444) has been identified in the miR-499 gene that can change the conformation of the secondary gene structure and thereby directly affect binding to target mRNAs and the microRNA (miRNA) maturation process, thus altering protein expression and potentially contributing to cancer susceptibility. Numerous studies investigating the associa­tion between the ... more

N. Wang; Z.Q. Tian; Y. Li; R.M. Zhou; G.Y. Wang
08/21/2013
Cancer; CASP-9; Gene polymorphisms; Meta-analysis

We investigated the association between CASP-9 polymorphisms and susceptibility to neoplasm. Fourteen studies with a total of 2733 neoplasm cases and 3352 healthy controls were included. Meta-analysis showed that the rs4645981*T allele and the rs4645981*T allele carrier were positively associated with neoplasm susceptibility [odds ratio (OR) = 1.43, 95% confidence interval (95%CI) = 1.12- ... more

Z.Y. Zhang; Y. Xuan; X.Y. Jin; X. Tian; R. Wu
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Anthracycline-related cardiotoxicity; Anthracyclines; Cancer; Carbonyl reductase 1 (cbr1); Domestic dog (Canis lupus familiaris); Doxorubicin

The anticancer anthracyclines doxorubicin and daunorubicin are used to treat a variety of cancers in dogs. The therapeutic utility of anthracyclines is limited by cardiotoxicity in some cases. Synthesis of anthracycline alcohol metabolites by carbonyl reductase 1 (CBR1) is crucial for the pathogenesis of cardiotoxicity. We hypothesize that genetic polymorphisms in canine cbr1 ... more

Q. Cheng; C. Sanborn; D. Ferguson; J.G. Blanco
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Cancer; Chromosome aberration; DNA repair genes; Molecular epidemiology

Endometriosis is a complex disease that has both benign and malignant characteristics. It affects 5-10% of women of reproductive age. Studies have demonstrated the existence of common genetic changes in endometriosis and ovarian cancer, suggesting a possible association between these 2 diseases. However, the mechanisms that lead to the development of cancer from endometriosis remain ... more

M.S. Monteiro; D.B.Vilas Boas; C.B. Gigliotti; D.M.F. Salvadori
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Cancer; Disparities; IL-6; Polymorphism; Prostate

Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation could be linked to genetic factors, including genetic polymorphism ... more

S. Mandal; F. Abebe; J. Chaudhary
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Cancer; Cytosolic serine hydroxymethyltransferase C1420T; Meta-analysis; Single nucleotide polymorphism

Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results. To derive a more precise estimation of the relationship, we performed a meta-analysis of 23 published studies that included 14,409 cancer cases and 16,996 controls. A comprehensive search was ... more

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