Research Article

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In this study, we evaluated the genotype profile of GSTM1 and GSTT1 polymorphisms in patient carriers of primary open-angle glaucoma in the population of Goiânia, GO, Brazil. This case-control study included 100 Brazilian patients with glaucoma and 53 patients without glaucoma. Blood samples were genotyped for polymorphisms in GST genes using polymerase chain reaction-based ... more

C.T.X. Silva; N.B. Costa; K.S.F. Silva; R.E. Silva; K.K.V.O. Moura
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Acute myeloid leukemia; Interleukin-10; Polymorphism

We investigated the association between polymorphisms in interleukin-10 (IL-10) -1082G/A (rs1800896), -819T/C (rs1800871), and -592A/C (rs1800872) and the risk of acute myeloid leukemia (AML) in a Chinese population. A total of 167 primary AML cases and 328 healthy control subjects were recruited at the First People’s Hospital of Yunnan Province between March 2009 and January ... more

C. Fei; X.M. Yao; Y. Sun; X.Z. Gu; L.Q. Yu; X. Lai
09/18/2002
Brazil; Glutathione S-transferase; Polymorphism

The glutathione S-transferase (GST) family of enzymes has a vital role in phase II of biotransformation of environmental carcinogens, pollutants, drugs and other xenobiotics. GSTs are polymorphic, with the type and frequency of polymorphism being ethnic dependent. Polymorphisms in GST genes have been shown to be associated with susceptibility to disease and disease outcome. We ... more

A. Rossini; D.C.M. Rapozo; L.M.F. Amorim; J.M.B. Macedo; R. Medina; J.F.N. Neto; C.V.M. Gallo; L.F.R. Pinto
12/09/2011
Glutathione S-transferase; Multiplex PCR; Polymorphism; Type-2 diabetes mellitus

Glutathione S-transferase (GST) protects cells against oxidative stress. We evaluated the effect of genetic polymorphisms of the GST gene family on the risk of developing type-2 diabetes mellitus and on glycemic control. We also investigated the effects of smoking combined with these polymorphisms on type-2 diabetes mellitus risk. We enrolled 100 type-2 diabetes mellitus patients and 100 ... more

M.A. Amer; M.H. Ghattas; D.M. Abo-ElMatty; S.H. Abou-El-Ela
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Chronic obstructive pulmonary disease; Genetic polymorphism; Glutathione S-transferase

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved in susceptibility to develop COPD. It belongs to the ... more

R. Lakhdar; S. Denden; J. Knani; N. Leban; H. Daimi; M. Hassine; G. Lefranc; J. Ben Chibani; H. Khelil
10/10/2013
Alkaline phosphatase; Cantharidin; Glutathione S-transferase; Helicoverpa armigera

The molecular and biochemical effects of an insecticidal toxin extracted from Meloidae beetles were investigated on Helicoverpa armigera. The toxin was identified as cantharidin, a well-known natural compound produced by beetles of family Meloidae and Oedemeridae. Furthermore, the effect of the toxin on the metabolic enzymes alkaline phosphatase (ALP) and glutathione S- ... more

R.A. Khan; M. Rashid; D. Wang; Y.L. Zhang
12/21/2012
Camelina sativa; CMGSTF12; Glutathione S-transferase; TT19

Recently, we found that the Arabidopsis TT19 protein, a glutathione S-transferase, has two functional domains that influence both anthocyanin and proanthocyanidin accumulation. To further understand the function of this protein in the other species, we cloned a cDNA encoding a glutathione S-transferase (namely CMGSTF12) from Camelina sativa, an ... more

Y. Wang; Y. Tang; M. Zhang; F. Cai; J. Qin; Q. Wang; C. Liu; G. Wang; L. Xu; L. Yang; J. Li; Z. Wang; X. Li
12/14/2015
Genetic polymorphisms; Glutathione S-transferase; SA; Turabah

Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion variants ... more

A.A. Mansour; O.M. Saleh; T. Askar; A.M. Salim; A. Mergani
04/07/2016
Cardiovascular disease; Glutathione S-transferase; Malaysia; Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is believed to be associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress, and have been associated with cardiovascular disease (CVD). The present study assessed the effect of GST polymorphisms on the ... more

A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail; A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail; A. Etemad; R. Vasudevan; A.F.A. Aziz; A.K.M. Yusof; S. Khazaei; N. Fawzi; S. Jamalpour; M. Arkani; N.A. Mohammad; P. Ismail
12/21/2005
Breast cancer; Polymorphisms; RAD51-G135C; XPD-Lys751Gln; XRCC1-Arg399Gln; XRCC3-Thr241Met

Several studies have reported that the genes involved in DNA repair and in the maintenance of genome integrity play a crucial role in protecting against mutations that lead to cancer. Epidemiologic evidence has shown that the inheritance of genetic variants at one or more loci results in a reduced DNA repair capacity and in an increased risk of cancer. Polymorphisms have been ... more

R.Mucha Dufloth; S. Costa; F. Schmitt; L.Carlos Zeferino

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