Research Article

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We investigated a possible association of collagen IX tryptophan (Trp) alleles (Trp2 and Trp3) and smoking with cervical spondylotic myelopathy (CSM) in 172 Chinese patients and 176 age- and gender-matched controls. The smoking status was evaluated by smoking index (SI). The CSM cases had a significantly higher prevalence of Trp2 alleles (Trp2+) than controls (19.8 vs 6.2%, P = 0 ... more

Z.C. Wang; J.G. Shi; X.S. Chen; G.H. Xu; L.J. Li; L.S. Jia
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Ethnicity; Fat mass- and obesity-associated; Polymorphisms; Solute carrier family 30 member 8; Type 2 diabetes mellitus

Recent genome wide association studies identified many loci in several genes that have been consistently associated with type 2 diabetes mellitus in various ethnic populations. Among the genes that were most strongly associated with diabetes were fat mass- and obesity-associated, melanocortin 4 receptor, solute carrier family 30 member 8 (SLC30A8), and a member of the potassium voltage- ... more

M.D. Bazzi; F.A. Nasr; M.S. Alanazi; A. Alamri; A.A. Turjoman; A.S. Moustafa; A.A. Alfadda; A.A.K. Pathan; N.R. Parine
01/24/2014
Folate intake; Gastric cancer; Methylenetetrahydrofolate reductase; Polymorphisms

Folic acid and methylenetetrahydrofolate reductase (MTHFR) may both affect the development of human cancer. We conducted a population-based case-control study in a Chinese population to investigate the potential role of folate intake and MTHFR gene polymorphisms in gastric cancer, and their interaction with infection by Helicobacter pylori and tumor location. A total of ... more

J. Chen; L. Yuan; Y.Q. Duan; J.Q. Jiang; R. Zhang; Z.J. Huang; X.R. Xiao
10/27/2014
Glutamate receptor; Heroin addiction; Ionotropic; N-methyl D-aspartate 2A; Polymorphisms

Heroin dependence is a debilitating psychiatric disorder with a complex inheritance mechanism. Genetic polymorphisms in functional regions of the glutamate receptor, N-methyl D-aspartate 2A (GRIN2A) gene, which encodes the 2A subunit of the N-methyl D-aspartate (NMDA) receptor, may modulate the risk of heroin addiction. We investigated the potential association between 8 single ... more

H.J. Zhong; Z.H. Huo; J. Dang; J. Chen; Y.S. Zhu; J.H. Liu
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Polymorphisms; Serotonin; Tobacco smoking

Previous studies have revealed a genetic component, including genetic polymorphisms in the serotonergic pathway, particularly in the serotonin receptor gene (5-HT2A). The aim of this study was to investigate associations of the T102C (rs6313) and A-1438G (rs6311) polymorphisms with tobacco use in a population from northeastern Brazil. We evaluated these polymorphisms in 135 ... more

E.S.Ramos Neto; J.O. Mágulas; J.J.S. Sousa; A.C.M. Moura; G.R. Pinto; F.K.N. Yoshioka; R. Canalle; F.J.N. Motta
10/07/2014
Body measurement traits; Meat quality traits; Polymorphisms; Qinchuan cattle; Smoothened

Beef cattle breeding programs focus on improving important economic traits, including growth rates, and meat quantity and quality. Molecular marker-assisted selection based on genetic variation represents a potential method for breeding genetically improved livestock with better economic traits. Smoothened (SMO) protein is a signal transducer that contributes to the regulation of both ... more

Y.R. Zhang; Y.K. Li; C.Z. Fu; J.L. Wang; H.B. Wang; L.S. Zan
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Colorectal cancer; MicroRNA-27a; Polymorphisms

Polymorphisms in pri-, pre-, and mature-microRNAs (miRNAs) have been proposed to be associated with various human cancers. Common single nucleotide polymorphisms (SNPs) in miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation. Through genotyping the rs895819 SNP in 254 colorectal cancer (CRC) patients and 238 healthy controls by polymerase chain ... more

Y. Cao; J. Hu; Y. Fang; Q. Chen; H. Li
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HCC risk; Hepatocellular carcinoma; miR-149C>T; Polymorphisms

MicroRNAs (miRNAs) are thought to play a role in cancer development. We conducted a case-control study to investigate the association between polymorphisms in miR-149C>T and hepatocellular carcinoma (HCC) risk. Duplex polymerase chain reaction with the confronting 2-pair primers were taken to genotype miR-149C>T. The association between genotype frequencies of miR-149C>T and risk ... more

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07/25/2014
Complete linkage disequilibrium; DSG4 gene; Polymorphisms; Sheep; Wool crimp; Wool length

The desmoglein 4 (DSG4) gene is a potential candidate in the search for genes that may affect wool traits, because of its function. This study aimed to screen for polymorphisms in partial exon 16 and 3ꞌUTR of the sheep desmoglein 4 DSG4 gene, and to test its possible association with wool length and crimp associated with fur. Overall, 326 sheep were scanned via ... more

Y.H. Ling; H. Xiang; G. Zhang; J.P. Ding; Z.J. Zhang; Y.H. Zhang; J.L. Han; Y.H. Ma; X.R. Zhang
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Hepatocellular carcinoma; MicroRNA; Polymorphisms

We investigate the potential association of miR-149C>T and miR-499A>G polymorphisms and the risk of hepatocellular carcinoma (HCC). A matched case-control study of 152 cases and 304 controls were conducted. The miR-149C>T and miR-499A>G genotypes were analyzed using duplex polymerase chain reaction with restricted fragment length polymorphism. HCC patients were more likely to ... more

X.H. Wang; F.R. Wang; Y.F. Tang; H.Z. Zou; Y.Q. Zhao

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