Research Article

Related GMR Articles

06/29/2012
Keloid; Meta-analysis; p53 codon 72 polymorphism; susceptibility

Although there is evidence suggesting genetic susceptibility for keloids, studies investigating the association between Arg72Pro polymorphism in the P53 gene and tendency to form keloids have given variable results. We made a meta-analysis of the effects of P53 Arg72Pro polymorphism on keloid risk in the Chinese population by conducting searches of the published literature in ... more

Y. Wu; B. Wang; Y.H. Li; X.G. Xu; Y.J. Luo; J.Z.S. Chen; H.C. Wei; X.H. Gao; H.D. Chen
05/15/2012
Killer cell immunoglobulin-like receptor; Polymorphism; Pulmonary tuberculosis; susceptibility

Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese Han. We analyzed 15 KIR genes in 109 pulmonary tuberculosis ... more

C. Lu; Y.J. Shen; Y.F. Deng; C.Y. Wang; G. Fan; Y.Q. Liu; S.M. Zhao; B.C. Zhang; Y.R. Zhao; Z.E. Wang; C.Z. Zhang; Z.M. Lu
02/10/2012
17q21; Asthma; Genetic variants; susceptibility

A genome-wide study has shown an association between SNPs located on 17q21 and asthma. Such associations have been identified in several populations, but little is known about the Han Chinese population. We conducted a case-control study in a Han Chinese population to investigate the relationship between SNPs located on 17q21 and asthma; 241 asthmatic patients and 212 healthy controls ... more

F.X. Li; J.Y. Tan; X.X. Yang; Y.S. Wu; D. Wu; M. Li
10/20/2014
Atrial fibrillation; KCNE1; Meta-analysis; Polymorphism; susceptibility

KCNE1, a membrane protein that spans the membrane once is responsible for modulating potassium channel functions and plays an important role in the etiology of arrhythmia. Emerging evidence indicates that a common polymorphism (112G>A; rs1805127 G>A) in the KCNE1 gene contributes to atrial fibrillation (AF) risk; however, these studies showed inconclusive results. In this ... more

H.G. Han; H.S. Wang; Z. Yin; H. Jiang; M. Fang; J. Han
08/29/2014
Genetic polymorphisms; Hepatocellular carcinoma; MDR1 gene; Risk factors; susceptibility

The objective of this study was to evaluate the influence of c.1564A>T genetic polymorphisms in the multidrug resistance 1 gene (MDR1) on hepatocellular carcinoma (HCC) susceptibility through association analysis. A total of 632 HCC patients and 645 cancer-free controls were enrolled in this study. The c.1564A>T genetic polymorphisms were genotyped by created restriction ... more

Y.Y. Wan; X.W. Wang; H.X. Hui; L. Wan
08/15/2014
Digestive cancer; Hypoxia inducible factor-1α; Meta-analysis; Polymorphism; susceptibility

Recent evidence suggests that common functional polymorphisms in the hypoxia inducible factor-1α (HIF-1α) gene may play an important role in the development and progression of digestive cancer, but individually published results are inconclusive. Our meta-analysis is aimed to derive a more precise estimation of the relationships between HIF-1αgene ... more

J.J. Xu; L.Y. Zou; L. Yang; X.L. He; M. Sun
07/24/2014
Gallbladder cancer; susceptibility; Vitamin D receptor

The aim of this study was to test for the possible association between vitamin D receptor (VDR) genetic variants and susceptibility to gallbladder cancer (GBC). A total of 291 GBC cases were recruited and 396 gender- and age-matched healthy volunteers were enrolled as controls. The VDR gene polymorphisms were determined in all subjects. The genotype and the allele frequencies of ... more

Z. Li; W.T. Yuan; S.J. Ning; S.J. Zhang
05/16/2014
Clinical outcome; Hepatocellular carcinoma; Polymorphism; susceptibility; XPD; XRCC1

We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC). A total of 218 cases with HCC and 277 healthy controls were included in the study. Genotyping of the XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms was ... more

J.S. Wu; Y.P. Chen; L.C. Wang; Y.J. Yang; C.W. Deng; B.X. Hou; Z.L. He; J.X. Chen
03/31/2014
Breast cancer; Excision repair cross-complimentary group 1; Polymorphisms; susceptibility; Xeroderma pigmentosum complementation group F

Breast cancer is one of the most frequently diagnosed cancer in women worldwide, and we conducted a case-control study by genotyping seven potentially functional SNPs, three in ERCC1 and four in XPF, in a Chinese population of 417 breast cancer cases and 417 cancer-free controls. Three SNPs in ERCC1 and four SNPs in XPF were genotyped by using the Taqman Universal PCR Master Mix in the ... more

X.H. Pei; Z. Yang; X.Q. Lv; H.X. Li
05/18/2015
Pancreatic cancer; rs9904341; susceptibility

We conducted a case-control study to investigate the association between the survivin rs9904341 G ... more

L. Qin; T. Yu

Pages