Research Article

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05/18/2015
Cyclin D1 G870A; Hepatocellular carcinoma; Leukemia; Polymorphism; susceptibility

Cyclin D1 (CCND1) is a key protein involved in cell-cycle regulation, and the CCND1 G870A polymorphism is associated with many types of malignancy. Studies examining the associations between this G870A polymorphism and susceptibility to leukemia and hepatocellular carcinoma (HCC) have shown inconsistent results. Therefore, we conducted a meta-analysis to clarify these ... more

Y. Zhao; H.R. He; M.Y. Wang; X.D. Ren; L. Zhang; Y.L. Dong; J. Lu
12/09/2008
Multidrug resistance; multidrug resistance protein; Single nucleotide polymorphism

One of the main problems in treating cancer patients is that cancer cells can develop drug resistance. Resistance to multiple anticancer drugs, so called multidrug resistance (MDR), most likely involves a nonspecific mode of resistance, through drug-efflux transporters. One of the most extensively studied genes involved in MDR is multidrug resistance protein 1 (MRP1). We investigated ... more

F. Mahjoubi; S. Akbari; M. Montazeri; F. Moshyri
12/14/2011
Carcass traits; quantitative trait locus; Single nucleotide polymorphism; Sus scrofa chromosome 7 (SSC7)

Many QTLs for fatness traits have been mapped on pig chromosome 7q1.1-1.4 in various pig resource populations. Eight novel markers, including seven SNPs and one insertion or deletion within BTNL1, COL21A1, PPARD, GLP1R, MDFI, GNMT, ABCC10, and PLA2G7 genes, as well as two previously reported SNPs in SLC39A7 and ... more

W.H. Huang; Z.X. Ma; Z.Y. Xu; Y.Z. Xiong; B. Zuo
09/27/2011
Allelic frequencies; meat quality; Myogenic determination gene 1; Qinchuan cattle; Single nucleotide polymorphism

The myogenic determination 1 (MyoD1) gene is a member of the MyoD gene family. It encodes for skeletal muscle-specific transcription factors containing highly conserved basic helix-loop-helix regions that perform important roles in the initiation, maintenance, and regulation of phenotypic traits. We investigated a new single nucleotide polymorphism (SNP) in the MyoD1 gene to evaluate ... more

J.A. Ujan; L.S. Zan; H.B. Wang; S.A. Ujan; C. Adoligbe; H.C. Wang; S.F. Biao
08/26/2011
Dairy cattle; Fertility; Growth hormone; IGF-1; Single nucleotide polymorphism

The somatotrophic axis (GH-IGF) is a key regulator of animal growth and development, affecting performance traits that include milk production, growth rate, body composition, and fertility. The aim of this study was to quantify the association of previously identified SNPs in bovine growth hormone (GH1) and insulin-like growth factor 1 (IGF-1) genes with direct ... more

M.P. Mullen; C.O. Lynch; S.M. Waters; D.J. Howard; P. O’Boyle; D.A. Kenny; F. Buckley; B. Horan; M.G. Diskin
08/26/2011
Cathechol-o-methyltransferase; Dopamine D3 receptor; Polymerase chain reaction; Restriction fragment length polymorphism; Schizophrenia; Single nucleotide polymorphism

Molecular components of the dopamine D3 receptor (DRD3) may play an important role in the pathophysiology of schizophrenia. Previous studies have demonstrated an association between DRD3 Ser9Gly and cathechol-o-methyltransferase (COMT, SNP = rs165656) polymorphisms and schizophrenia but the results were inconclusive. We investigated this apparent association between Ser9Gly (A/G) ... more

S.F. Tee; P.Y. Tang; H.C. Loh
05/17/2011
Essential hypertension; Mongolian population; Single nucleotide polymorphism; TSC

We investigated a possible association between genetic variations in the thiazide-sensitive Na-Cl cotransporter (TSC) gene and essential hypertension (EH) in the Mongolian and Han ethnic groups in Inner Mongolia. Our study included 385 unrelated Mongolian herdsmen and 523 Han farmers. Nine tagSNPs of TSC were identified from the Chinese HapMap database based on pairwise ... more

P.Y. Chang; L.G. Zhao; X.L. Su
03/29/2011
Aldehyde dehydrogenase 2; Essential hypertension; Mongolian nationality; Single nucleotide polymorphism

Mongolians are known as heavy drinkers, and they have a high incidence of essential hypertension, which may be an associated pathology. We examined a possible association of essential hypertension and polymorphism of the aldehyde dehydrogenase 2 (ALDH2) gene in Mongolians from Inner Mongolia. Single nucleotide polymorphism rs671 of ALDH2 was detected by TaqMan PCR in 91 essential ... more

T. Hasi; L. Hao; L. Yang; X.L. Su
06/22/2010
Association study; Major depressive disorder; Rs6311; Serotonin 2A receptor; Single nucleotide polymorphism; Thai population

Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major depressive disorder (MDD) in a northeastern Thai ... more

T. Tencomnao; V. Thongrakard; W. Phuchana; T. Sritharathikhun; S. Suttirat
06/15/2010
CDKAL1; Meta-analysis; Single nucleotide polymorphism; Type 2 diabetes

CDKAL1 (cyckin-dependent kinase 5 regulatory subunit-associated protein 1-like 1) has been shown to be associated with type 2 diabetes in various ethnic groups; however, contradictory results have been reported. We performed a comprehensive meta-analysis of 21 studies for rs7756992, 17 studies for rs7754840 and 10 studies for rs10946398 variants of the CDKAL1 gene to ... more

M.A.S. Dehwah; M. Wang; Q.Y. Huang

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