Research Article

Related GMR Articles

04/15/2015
Colorectal cancer; IGFBP-3; Meta-analysis; Meta-regression; Polymorphism

Recent evidence suggests that genetic variations in the IGFBP-3 gene may impact susceptibility to colorectal cancer, but individually published results are inconclusive. Our meta-analysis was aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 1, 2013. This meta-analysis was ... more

J. Xu; L. Xu; L.T. Li; Q. You; L.S. Cha
01/30/2015
Colorectal cancer; Excision repair cross-complementing group 1; Genetic polymorphisms; Xeroderma pigmentosum group F

We conducted a hospital-based case-control study to evaluate the association between polymorphisms in excision repair cross-complementing group 1-xeroderma pigmentosum group F (ERCC1-XPF) variants and the risk of colorectal cancer in a Chinese population. Genotyping of the ERCC1 rs2298881 and rs11615 and XPF rs2276466 polymorphisms were detected by polymerase ... more

H. Yang; G. Li; W.F. Li
11/18/2013
-308G>A; Breast cancer; Mexican population; Obesity; Risk factor; Tumor necrosis factor alpha

The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes of 294 healthy Mexican women with ... more

G. Flores-Ramos; E. De Dios; A.M. Puebla-Pérez; L.E. Figuera-Villanueva; A. Ramos-Silva; R. Ramírez-Patiño; J.I. Delgado-Saucedo; E. Salas-González; G.M. Zúñiga-González; A. Alonzo-Rojo; I. Gutiérrez-Hurtado; M.P. Gallegos-Arreola
05/15/2012
Codon 72; Endometriosis; Mexican population; Polymorphism; TP53 gene

The TP53 tumor suppressor gene plays an important role in cell cycle regulation; polymorphisms of this gene have been associated with endometriosis. We examined the role of TP53 codon 72 polymorphism by comparing genotypes of 235 healthy Mexican women (controls with surgically excluded endometriosis) with the genotypes of 151 Mexican women with endometriosis. The observed genotype ... more

M.P. Gallegos-Arreola; L.E. Figuera-Villanueva; A.M. Puebla-Pérez; H. Montoya-Fuentes; A.E. Suarez-Rincon; G.M. Zúñiga-González
04/27/2015
Breast cancer; C677T polymorphism; Mexican population; MTHFR

The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to ... more

A. Ramos-Silva; L.E. Figuera; O.M. Soto-Quintana; A.M. Puebla-Pérez; R. Ramírez-Patiño; I. Gutiérrez-Hurtado; D.I. Carrillo-Moreno; G.M. Zúñiga-González; I.P. Dávalos-Rodríguez; M.P. Gallegos-Arreola
05/17/2006
C677T polymorphism; Colorectal cancer; Hypermethylation; Methylenetetrahydrofolate reductase; Microsatellite instability; MTHFR

The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with the expression of a thermolabile enzyme with decreased activity that influences the pool of methyl-donor molecules. Several studies have reported an association between C677T polymorphism and susceptibility to colorectal cancer (CRC). Considering that methylation abnormalities appear to be important for the ... more

A.D. Clarizia; L. Bastos-Rodrigues; H.B. Pena; C. Anacleto; B. Rossi; A. Lopes; J.Cláudio C. Rocha; O. Caballero; A. Camargo; A.J.G. Simpson; S.D.J. Pena; F.A. Soares
12/08/2011
Colorectal cancer; Meta-analysis; Polymorphism; VEGF

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains controversial. We made a meta-analysis of the association ... more

L.P. Zhou; H. Luan; X.H. Dong; G.J. Jin; D.L. Man; H. Shang
06/21/2011
Colorectal cancer; Kashmir; MTHFR; Polymorphism; Restriction digestion; RFLP

Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism has been widely investigated in different cancers and has been ... more

A.S. Sameer; Z.A. Shah; S. Nissar; S. Mudassar; M.A. Siddiqi
04/13/2010
Colorectal cancer; Kashmir; Polymorphism; Restriction digestion; RFLP; TP53

Two TP53 gene polymorphisms at codon 47 (TP53 Pro47Ser) and at codon 72 (TP53 Arg72Pro) have been associated with susceptibility to various cancers. We carried out a case-control study and examined the genotype distribution of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms (SNPs), using a PCR-RFLP approach, to determine if these two SNPs are ... more

A.S. Sameer; Z.A. Shah; N. Syeed; M.Z. Banday; S.M. Bashir; B.A. Bhat; M.A. Siddiqi
07/08/2013
Association signal; Colorectal cancer; IL6 gene; Meta-analysis; Polymorphism

Interleukin 6 (IL6) is a pleiotropic cytokine involved in physiological processes and in a variety of human malignancies. It is thus a logical candidate for being a causative factor underlying colorectal cancer (CRC). The association between the IL6 -174G>C polymorphism and CRC has been widely evaluated; yet, there is a lack of agreement between studies on the role of ... more

J.J. Hu; Z.T. Wang; J. Zhong

Pages