Research Article

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R. Camacho-Mejorado; G. Noris; C. Santana; J.J. Magaña; A. Majluf-Cruz; J. Arellano-Galindo; A. De la Peña; J. Hernández-Juárez; E.S. Calderón-Aranda; M.A. Meraz-Ríos; R. Gómez
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03/13/2015
Diabetic nephropathy; INSR; mTOR; Polymorphisms; Type 2 diabetes mellitus

We explored the associations of INSR and mTOR, 2 key genes in the insulin signaling pathway, and the susceptibility to type 2 diabetes mellitus and diabetic nephropathy. Three single-nucleotide polymorphisms (SNPs) (rs1799817, rs1051690, and rs2059806) in INSR and 3 SNPs (rs7211818, rs7212142, and rs9674559) in mTOR were genotyped using the Sequenom ... more

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MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association between ... more

S.A. Gutiérrez-Rubio; A. Quintero-Ramos; A. Durán-Cárdenas; R.A. Franco-Topete; J.M. Castro-Cervantes; A. Oceguera-Villanueva; L.M. Jiménez-Pérez; L.M.A. Balderas-Peña; G. Morgan-Villela; A. Del-Toro-Arreola; A. Daneri-Navarro
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Tibetan sheep, an indigenous breed, have a wide variety of phenotypes and a colorful coat, which make this breed an interesting model for evaluating the effects of coat-color gene mutations on this phenotypic trait. The agouti signaling protein (ASIP) gene is a positional candidate gene, as was inferred based on previous study. In our research, ASIP gene copy numbers in ... more

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Autoimmune polyglandular syndrome type III; Fyn-binding protein; Polymorphisms; T1DM

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