Research Article

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The glutathione S-transferase (GST) family comprises phase-II cellular detoxification enzymes that catalyze the conjugation of chemotherapy drugs to glutathione and act on the apoptotic pathway. The aim of this study was to determine whether polymorphisms of the GSTT1, GSTM1, and GSTP1 genes are associated with different rates of overall survival (OS) and disease ... more

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Breast cancer is one of the most frequently diagnosed cancer in women worldwide, and we conducted a case-control study by genotyping seven potentially functional SNPs, three in ERCC1 and four in XPF, in a Chinese population of 417 breast cancer cases and 417 cancer-free controls. Three SNPs in ERCC1 and four SNPs in XPF were genotyped by using the Taqman Universal PCR Master Mix in the ... more

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BRCA1 gene; Breast cancer; Clinical samples; Exon sequencing; Mutation

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A. Tazzite; S. Nadiffi; D. Kottwitz; E. Amrani; H. Jouhadi; A. Benider; A. Moumen; H. Sefrioui
06/11/2015
Breast cancer; Ethnicity; Glutathione S-transferases; Northeastern Mexico; Polymorphisms

Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer. The purpose of this study was to ... more

G. Jaramillo-Rangel; M. Ortega-Martínez; R.M. Cerda-Flores; H.A. Barrera-Saldaña
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Breast cancer; MicroRNA; Polymorphism

Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide polymorphisms (mir-499 rs3746444 A> ... more

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Breast cancer; C677T polymorphism; Mexican population; MTHFR

The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to ... more

A. Ramos-Silva; L.E. Figuera; O.M. Soto-Quintana; A.M. Puebla-Pérez; R. Ramírez-Patiño; I. Gutiérrez-Hurtado; D.I. Carrillo-Moreno; G.M. Zúñiga-González; I.P. Dávalos-Rodríguez; M.P. Gallegos-Arreola
04/13/2015
Breast cancer; Immunohistochemistry; Special AT-rich sequence binding protein 1

Special AT-rich sequence binding protein 1 (SATB1) is a recently discovered gene regulator that can promote the growth and metastasis of breast cancer. However, its expression in different stages of breast cancer development have not been examined. We explored the role of SATB1 in the development of breast cancer by detecting SATB1 expression levels in different stages of breast cancer. ... more

S. Zhang; X. Gao; Y. Ma; J. Jiang; Z. Dai; X. Yin; W. Min; W. Hui; B. Wang
02/13/2015
Breast cancer; Diagnosis; Functional imaging; Gold-standard assessment; Heat source analysis

Nondestructive preoperative breast imaging techniques are widely used for breast cancer testing and diagnosis. This study aimed to evaluate the feasibility and efficacy of quantitative diagnosis via the thermal analysis of abnormal metabolism. Nine hundred forty-eight women who underwent breast biopsy from 2009 to 2013 were investigated. Thermal analysis was used to calculate the internal ... more

F. Han; C.W. Liang; G.L. Shi; L. Wang; K.Y. Li
02/13/2015
ABCB1; Breast cancer; MDR1; Polymorphisms; Pre- and postmenopausal women

MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association between ... more

S.A. Gutiérrez-Rubio; A. Quintero-Ramos; A. Durán-Cárdenas; R.A. Franco-Topete; J.M. Castro-Cervantes; A. Oceguera-Villanueva; L.M. Jiménez-Pérez; L.M.A. Balderas-Peña; G. Morgan-Villela; A. Del-Toro-Arreola; A. Daneri-Navarro
12/21/2005
Breast cancer; Polymorphisms; RAD51-G135C; XPD-Lys751Gln; XRCC1-Arg399Gln; XRCC3-Thr241Met

Several studies have reported that the genes involved in DNA repair and in the maintenance of genome integrity play a crucial role in protecting against mutations that lead to cancer. Epidemiologic evidence has shown that the inheritance of genetic variants at one or more loci results in a reduced DNA repair capacity and in an increased risk of cancer. Polymorphisms have been ... more

R.Mucha Dufloth; S. Costa; F. Schmitt; L.Carlos Zeferino

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