Research Article

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C677T polymorphism; Colorectal cancer; Hypermethylation; Methylenetetrahydrofolate reductase; Microsatellite instability; MTHFR

The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with the expression of a thermolabile enzyme with decreased activity that influences the pool of methyl-donor molecules. Several studies have reported an association between C677T polymorphism and susceptibility to colorectal cancer (CRC). Considering that methylation abnormalities appear to be important for the ... more

A.D. Clarizia; L. Bastos-Rodrigues; H.B. Pena; C. Anacleto; B. Rossi; A. Lopes; J.Cláudio C. Rocha; O. Caballero; A. Camargo; A.J.G. Simpson; S.D.J. Pena; F.A. Soares
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Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis. Polymorphisms of the VEGF gene have been associated with susceptibility to colorectal cancer (CRC). However, the specific association still remains controversial. We made a meta-analysis of the association ... more

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Colorectal cancer; Kashmir; MTHFR; Polymorphism; Restriction digestion; RFLP

Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism has been widely investigated in different cancers and has been ... more

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Colorectal cancer; Kashmir; Polymorphism; Restriction digestion; RFLP; TP53

Two TP53 gene polymorphisms at codon 47 (TP53 Pro47Ser) and at codon 72 (TP53 Arg72Pro) have been associated with susceptibility to various cancers. We carried out a case-control study and examined the genotype distribution of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms (SNPs), using a PCR-RFLP approach, to determine if these two SNPs are ... more

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Interleukin 6 (IL6) is a pleiotropic cytokine involved in physiological processes and in a variety of human malignancies. It is thus a logical candidate for being a causative factor underlying colorectal cancer (CRC). The association between the IL6 -174G>C polymorphism and CRC has been widely evaluated; yet, there is a lack of agreement between studies on the role of ... more

J.J. Hu; Z.T. Wang; J. Zhong
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Colorectal cancer; DNA hypomethylation; Epigenetics; Gene expression; Metastasis

DNA methylation is a fundamental epigenetic mechanism in regulating the expression of genes controlling crucial cell functions in cancer development. Gene silencing via CpG island methylation/demethylation in the promoter region is one of the mechanisms by which different genes are inactivated/activated in human cancers. Tissue inhibitor of metalloproteinase-2 (TIMP-2) is known to ... more

Z. Hussain; M.I. Khan; M. Shahid; F.N. Almajhdi
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Colorectal cancer; Interleukin-10; Meta-analysis; Polymorphism

In order to make a comprehensive assessment of the potential association between two genetic variants in the IL-10 gene promoter, -1082 A>G (rs1800896) and -592 C>A (rs1800872), and colorectal cancer (CRC) risk, we conduced a meta-analysis of seven epidemiological studies, which included 1469 colorectal cancer cases and 2566 controls. Neither of the two polymorphisms had any ... more

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Colorectal cancer; CYP2E1; Polymorphism

We investigated a possible association between alcoholism, cigarette smoking, obesity and CYP2E1 RsaI and 96-bp insertion genetic polymorphisms with risk for colorectal cancer (CRC). Patients with CRC (70 women and 61 men) were matched for gender and age to 206 healthy controls. The mean age of the two groups was 62 years. Meat intake, cigarette smoking and alcohol drinking were ... more

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Colorectal cancer; Mexican population; MLH1 gene; XRCC1 gene

DNA repair proteins maintain DNA integrity; polymorphisms in genes coding for these proteins can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in Mexican patients. Genomic DNA samples were obtained from peripheral blood of 108 ... more

R. Muñiz-Mendoza; M.L. Ayala-Madrigal; M. Partida-Pérez; J. Peregrina-Sandoval; E. Leal-Ugarte; N. Macias-Gomez; V. Peralta-Leal; J.P. Meza-Espinoza; J.M. Moreno-Ortiz; R. Ramírez-Ramírez; S. Suárez-Villanueva; M. Gutierrez-Angulo
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Colorectal cancer; MicroRNA-27a; Polymorphisms

Polymorphisms in pri-, pre-, and mature-microRNAs (miRNAs) have been proposed to be associated with various human cancers. Common single nucleotide polymorphisms (SNPs) in miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation. Through genotyping the rs895819 SNP in 254 colorectal cancer (CRC) patients and 238 healthy controls by polymerase chain ... more

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