Research Article

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Acute kidney injury; Bone marrow-derived mesenchymal stem cells; Cell differentiation; Cytokines; Erythropoietin

We investigated the effect of erythropoietin (EPO) on differentiation and secretion of bone marrow-derived mesenchymal stem cells in an acute kidney injury microenvironment. Acute kidney injury mouse models were prepared. Both renal cortices were then immediately collected to produce the ischemia/reperfusion kidney homogenate supernatant. The morphological and ultrastructural changes in ... more

N.M. Liu; J. Tian; W.W. Wang; G.F. Han; J. Cheng; J. Huang; J.Y. Zhang
11/22/2013
Cytokines; Gold nanoparticles; In vivo toxicity; Inflammation; Rats

Most studies have used in vitro systems to test inflammatory responses of nanoparticles; these may not reflect the real biological response of body organs. In fact, certain nanoparticles have provoked opposite effects under in vitro and in vivo conditions. Current understanding of the biocompatibility of gold nanoparticles is controversial. We studied the acute ... more

H.A. Khan; M.A.K. Abdelhalim; A.S. Alhomida; M.S.Al Ayed
12/17/2012
Cytokines; Gingiva; Periodontitis; Real-time polymerase chain reaction

Periodontal disease is one of the most prevalent oral diseases. An association between this disease and pregnancy has been suggested, but available findings are controversial. We evaluated the expression levels of interleukins (IL-1β and IL-6), tumor necrosis factor-alpha (TNF-α), and inducible nitric oxide synthase (iNOS) in pregnant women with and without periodontal disease in ... more

C.C.M. Otenio; I. Fonseca; M.F. Martins; L.C. Ribeiro; N.M.S.P. Assis; A.P. Ferreira; R.A. Ribeiro
07/04/2014
Aspergillosis; Cytokines; Liver transplantation; Treg cells

Infection is the leading risk factor of liver transplantation-related death. Aspergillosis is a life-threatening complication in immune-compromised patients, and is the cause of approximately 2/3 of deaths in liver transplant recipients. In our previous studies, we found a regulatory T cell (Treg) population that showed significantly increased immune tolerance in Aspergillus- ... more

T. Xing; L. Zhong; G. Qiu; L. Huang; Z. Peng
02/03/2015
Cattle; Cross-reactivity; Cytokines; Goat; Human; Sheep

Eleven commercially available PE-labeled anti-human (IL-1-α, IL-6, IL-8, TNF-α, IL-17A, IL-5, IL-10, IL-12 and IL-13) and anti-mouse (IL-10, TNF-α) cytokine monoclonal antibodies (mAbs) were tested for cross-reactivity with cattle, goat, and sheep cytokines. Cross-reactivity was assessed by comparative analysis with the standard reactivity of the target species. Our data demonstrated ... more

E.M.S. Dorneles; M.S.S. Araújo; A. Teixeira-Carvalho; O.A. Martins-Filho; A.P. Lage
03/31/2003
Antigens; Cytokines; Lactococcus lactis; Mucosal vaccine; Secretion

Lactic acid bacteria (LAB), widely used in the food industry, are present in the intestine of most animals, including humans. The potential use of these bacteria as live vehicles for the production and delivery of heterologous proteins of vaccinal, medical or technological interest has therefore been extensively investigated. Lactococcus lactis, a LAB species, is a potential ... more

S. Nouaille; L.A. Ribeiro; A. Miyoshi; D. Pontes; Y. Le Loir; S.Costa Oliveira; S.Costa Oliveira; P. Langella; V. Azevedo
10/08/2014
Cytokines; GILZ; Glucocorticoid; Protein metabolism; Sepsis

Sepsis is a complex inflammatory response to infection, associating with dramatic metabolic disorders. Although the mechanisms of immune response during sepsis have been largely clarified, current studies rarely pay attention to the disordered protein metabolism in sepsis. In this study, L6 rat skeletal muscle cells treated with serum from septic rats were used as an in vitro ... more

J. Xiong; L. Xu; W.M. Qu; Z.L. Li; Z.H. Shang; Y.H. Li; S.H. Yang; Z.H. Yang
04/17/2015
C-Jun N-terminal kinase; Cytokines; Extracellular receptor kinase; Jurkat; Silver-gold nanoparticles; U937

Silver nanopaticles (AgNPs) and gold nanoparticles (AuNPs) have various applications in medical healthcare and various biological properties such as anti-inflammation, anti-cancer, and anti-angiogenesis. In this study, we investigated the effect of AgNPs and AuNPs on cytokine production via the mitogen-activated protein kinase pathway in leukemic cell lines (T-lymphocytic Jurkat and ... more

C. Parnsamut; S. Brimson
09/26/2014
Acrylonitrile; Bcl10 protein; Caveolin-1; Lipid rafts; MAPK

Acrylonitrile (ACN) is a widely used chemical in the production of plastics, resins, nitriles, acrylic fibers, and synthetic rubber. Previous epidemiological investigations and animal studies have confirmed that ACN affects the lymphocytes and spleen. However, the immune toxicity mechanism is unknown. Lipid rafts are cell membrane structures that are rich in cholesterol and involved in ... more

X.J. Li; B. Li; J.S. Huang; J.M. Shi; P. Wang; W. Fan; Y.L. Zhou
01/22/2014
BRAF V600E; Cutaneous melanoma; MAPK; Mutation

BRAF V600E is the most common mutation in cutaneous melanomas, and has been described in 30-72% of such cases. This mutation results in the substitution of valine for glutamic acid at position 600 of the BRAF protein, which consequently becomes constitutively activated. The present study investigated the BRAF V600E mutation frequency and its clinical implications in a ... more

J.S.S. Inumaru; K.I.F. Gordo; A.C.Fraga Junior; A.M.T.C. Silva; C.B.Q.S. Leal; F.M. Ayres; I.J. Wastowski; N.F. Borges; V.A. Saddi

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