Research Article

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04/17/2014
ERCC5; Non-small cell lung cancer; SNPs; XRCC1

We aimed to assess the role of polymorphisms of the XRCC1 Arg194Trp, XRCC1 Arg399Gln, ERCC5 His1104Asp, and ERCC5 His46His genes on clinical outcomes of advanced non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy regimens. A total of 378 NSCLC patients were asked to participate within 1 month after diagnosis between January 2005 and January 2006, and they ... more

D. Liu; J. Wu; G.Y. Shi; H.F. Zhou; Y. Yu
01/14/2014
Chemotherapy; Non-small cell lung cancer; XPD; XRCC1

Individual differences in chemosensitivity and clinical outcome of non-small-cell lung carcinoma (NSCLC) patients can be influenced by host-inherited factors. We investigated the impact of XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XPD Arg156Arg, XPD Asp312Asn, XPD Asp711Asp, and XPD Lys751Gln gene polymorphisms on ... more

L. Zhang; W. Ma; Y. Li; J. Wu; G.Y. Shi
06/26/2015
Gene; Genetics; Non-small cell lung cancer; Radiation effects; Radiation tolerance

The aim of this study was to examine the relationship between genetic polymorphisms in DNA ligase 1 (LIG1) and non-small cell lung cancer (NSCLC) susceptibility and radiosensitivity in a Chinese population. This was a case-control study that included 352 NSCLC patients and 448 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism analysis was conducted to ... more

H. Tian; X. He; L. Yin; W.J. Guo; Y.Y. Xia; Z.X. Jiang
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Brain metastasis; Non-small cell lung cancer; Polymorphism; TGFB1

We conducted a case-control study to investigate the role of 3 single-nucleotide polymorphisms of the gene encoding transforming growth factor-b1 (TGFB1) in the development of metastatic brain tumors in non-small cell lung cancer patients. The polymorphisms in TGFB1 rs4803455, rs1800469, and rs1800470 were evaluated by polymerase chain reaction-restriction fragment ... more

H.B. Wang; W.G. Song; H.Q. Liu; F. Fang; Y. Xiao
04/15/2015
MutS homolog 3; Non-small cell lung cancer; Platinum-based chemotherapy; Single nucleotide polymorphism

Mismatch repair (MMR) genes, as well as the nucleotide excision repair genes, play an important role in removing cisplatin-DNA adducts, and the mutation of MMR genes in tumors can lead to a decreased response to platinum-based therapies. We examined MutS homolog 3 (MSH3), a mismatch repair gene, and whether polymorphisms of MSH3 were associated with response and survival in advanced non- ... more

X.L. Xu; Y.L. Yao; W.Z. Xu; J.G. Feng; W.M. Mao
01/26/2015
Non-small cell lung cancer; Overall survival; Progression; Xeroderma pigmentosum group G

We conducted a cohort study to investigate whether 3 potential single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene could predict the survival of advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based doublet chemotherapy. We enrolled 262 patients with histologically confirmed NSCLC between November 2007 ... more

H.Z. Zou; Y.Q. Zhao
03/11/2013
Differentially expressed genes; Regulation network; Testicular seminoma

Testicular seminoma has become the most common solid malignancy in young men, especially in the 20s group. We obtained the gene expression profile of human testicular seminoma cells from NCBI, identified the differentially expressed genes of testicular seminoma cells of different stages, and constructed the regulation networks of different stages of testicular seminoma using ... more

J.J. Sha; Y.H. Dong; D.M. Liu; J.J. Bo; Y.R. Huang; Z. Li; P. Ping
10/07/2013
CMAP; Differentially expressed genes; Pulmonary hypoxia-related diseases; Similar drugs

Exposure of humans to low levels of environmental oxygen results in alveolar hypoxia and normally causes chronic pulmonary hypertension and morphological alterations of precapillary pulmonary vessels. In this study, the microarray dataset GSE11341 was used to identify potential differentially expressed genes related with human lung microvascular endothelial cell hypoxia. In addition, gene ... more

L. Zhou; L.M. Wang; H.M. Song; Y.Q. Shen; W.J. Xu; J.H. Xu; Y. Liu; W.W. Yan; J.F. Jiang
06/01/2015
Differentially expressed genes; Epstein-Barr virus-positive nasopharyngeal carcinoma; Target genes; Typical miRNAs

This study aims to identify the crucial miRNAs in Epstein-Barr virus-positive nasopharyngeal carcinoma (NPC) and their target genes. Gene expression profile data (GSE12452) that included 31 NPC and 10 normal nasopharyngeal tissue specimens were downloaded. Differentially expressed genes (DEGs) were identified using significance analysis of microarrays. The underlying function of DEGs was ... more

L.H. Zhu; X.T. Miao; N.Y. Wang
05/21/2013
Adenocarcinoma; Iterative signature algorithm; Squamous cell carcinoma

Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small cell lung cancer (NSCLC). Although differences in molecular, histological, and clinical characteristics have been reported for both subtypes, no specific therapy exists thus far. The aim of this analysis was to identify potential therapeutic target genes that are specific to SCC and AC. We ... more

L. Li; J. Zhu; S.X. Guo; Y. Deng

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