Research Article

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Alzheimer’s disease; Meta-analysis; MicroRNA; Oxidized low density lipoprotein receptor 1; Polymorphism

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that contributes to dementia in the elderly population. Genome-wide linkage analysis has identified chromosome 12p as the AD-susceptible region, which includes lectin-like oxidized low-density lipoprotein receptor 1 (OLR1). The OLR1 +1073 C/T single-nucleotide polymorphism is located in the 3'- ... more

Y. Kong; J.B. Wu; X. Wang; J.F. Zhao; H. Song; L.D. Yuan
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Hepatocellular carcinoma; MicroRNA; Polymorphisms

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Anencephaly; Bioinformatics; MAPK signaling pathway; Microarray; MicroRNA; Neural tube defect

Anencephaly is one of the most serious forms of neural tube defects (NTDs), a group of congenital central nervous system (CNS) malformations. MicroRNAs (miRNAs) are involved in diverse biological processes via the post-transcriptional regulation of target mRNAs. Although miRNAs play important roles in the development of mammalian CNS, their function in human NTDs remains unknown. Using a ... more

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Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide polymorphisms (mir-499 rs3746444 A> ... more

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Genetic mutations in microRNA gene can alter expression, which may interact to increase the risk of developing various diseases, including hepatitis B. However, published results are inconclusive or ambiguous. The aim of this review and meta-analysis is to more precisely estimate the association between polymorphisms in microRNA genes and hepatitis B risk. A digital search was performed ... more

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HBV; Hepatocellular carcinoma; MicroRNA; Polymorphisms

We conducted a hospital-based case-control study to investigate the effect of the miR-146aG>C and miR-499A>G polymorphisms on the risk of hepatocellular carcinoma (HCC) in a Chinese population. This study was 1:1 matched case-control study consisting of 184 HCC patients and 184 control subjects. miR-146aG>C and miR-499A>G polymorphisms were genotyped by polymerase chain ... more

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Adipose tissue; Evodiamine; Lipid; Liver; Mice; Obesity

Evodiamine is the main active alkali of Wu Zhuyu, a widely distributed Chinese herb. It plays an important role in the regulation of body fat deposition. In this study, we aimed to investigate the effect of evodiamine administration on the expression of genes involved in lipid metabolism in the liver and adipose tissue. Fasted mice were subcutaneously injected with evodiamine (37°C, 20 ... more

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Adipose tissue; Comet assay; Mesenchymal stem cells

The use of mesenchymal stem cells (MSCs) in experimental, clinical, and therapeutic trials has grown in recent years. However, the issue remains of whether these procedures are completely safe for transplant patients. Therefore, this study was designed and carried out with the aim of evaluating two different comet assay protocols for genomic damage pattern analysis in MSCs derived from ... more

L.C. Hermeto; R.J. Oliveira; R. Matuo; P.H.A. Jardim; R. DeRossi; A.C.M.B. Antoniolli; E. Deffune; T.C. Evaristo; Á.E. Santana
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Adipose tissue; Buffalo; Cattle; Cell therapy; Mesenchymal stem cells

Adult stem cells are known for their plasticity and their potential to differentiate into several different cell types; these characteristics have implications for cell therapy and reproductive biotechnologies. In this study, we report on the isolation and characterization of mesenchymal stem cells (MSC) derived from bovine and buffalo adipose tissue. Cells isolated using enzymatic ... more

R.V. Sampaio; M.R. Chiaratti; D.C.N. Santos; F.F. Bressan; J.R. Sangalli; A.L.A. Sá; T.V.G. Silva; N.N. Costa; M.S. Cordeiro; S.S.D. Santos; C.E. Ambrósio; P.R. Adona; F.V. Meirelles; M.S. Miranda; O.M. Ohashi

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