Research Article

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We examined the association of the interleukin-28B (IL-28B) gene rs12979860 T/C polymorphism with development of hepatitis virus-related hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library, and Chinese National Knowledge Infrastructure data bases. Pooled odds ratios (ORs) and ... more

G.J. Suo; Z.X. Zhao
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Gene polymorphism; Hepatocellular carcinoma; Meta-analysis; XRCC1

XRCC1-399 allele polymorphisms have been reported to be associated with susceptibility to hepatocellular carcinoma (HCC), but the conclusions of the various studies have been inconsistent. We conducted a meta-analysis of available studies to determine whether XRCC1-399 alleles influence susceptibility to hepatocellular carcinoma. We searched English-language databases, ... more

X.Y. Zeng; J.M. Huang; J.W. Xu; Y. Xu; H.P. Yu; L. Ji; X.Q. Qiu
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Asian; Hepatocellular carcinoma; Meta-analysis; Methylation; RUNX3

Runt-related transcription factor 3 (RUNX3) is a potential tumor suppressor that is frequently hypermethylated in hepatocellular carcinoma (HCC). The present meta-analysis of case-control studies was carried out to determine whether RUNX3 hypermethylation is associated with HCC. The PubMed, Embase, and Chinese National Knowledge Infrastructure databases were searched for ... more

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Hepatocellular carcinoma; Meta-analysis; Single nucleotide polymorphism; XRCC1-Arg280His

Hepatocellular carcinoma (HCC) is one of the most life-threatening malignancies worldwide. Defects in DNA repair genes may increase the risk of HCC. X-ray cross-complementing group 1 gene (XRCC1) is a major DNA repair gene involved in base excision re­pair. Recently, several studies have indicated that an association exists between XRCC1 polymorphism and HCC, ... more

W. Xu; S. Liu; L. Li; Z.Y. Shen; Y.L. Wu
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CYP1A1; Gene polymorphism; Hepatocellular carcinoma; Meta-analysis

Numerous studies have evaluated the association between CYP1A1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. However, the specific association is still controversial. The aim of our study was to clarify the effects of CYP1A1 gene polymorphisms (3801 T>C and A2455G) on HCC risk by conducting a meta-analysis. We conducted searches of the literature published in PubMed and ... more

B.W. Yu; L.Q. Zhang; X.L. Teng; Y. Zhang; L.B. Zou; H.Y. Ying
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Astrocytoma; Glioblastoma; GSTP1; Polymorphism

Glutathione S-transferases (GSTs) constitute a superfamily of ubiquitous multifunctional enzymes that are involved in the cellular detoxification of a large number of endogenous and exogenous chemical agents that have electrophilic functional groups. People who have deficiencies in this family of genes are at increased risk of developing some types of tumors. We examined GSTP1 Ile105Val ... more

A.C. Custódio; L.O. Almeida; G.R. Pinto; M.J. Santos; J.R.W. Almeida; C.A. Clara; J.A. Rey; C. Casartelli
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Association study; CYP27B1; EDN1; Genetic polymorphisms; GSTP1; Sarcoidosis

Sarcoidosis is a chronic inflammatory disease, characterized by granulomatous inflammation, prominently involving the respiratory system. The etiology of this disease has not yet been elucidated and the contribution of genetic is not yet completely understood. We searched for novel candidate genes, utilizing a system biology approach, based on data from published transcriptional, ... more

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Genetic variants; GSTA1; GSTP1; Haplotypes

Glutathione S-transferases (GST) A1 and P1 are crucial enzymes involved in the biotransformation of drugs, carcinogens, and toxins, and their activity may influence drug response, susceptibility to diseases, and carcinogenesis. The genes encoding these enzymes, GSTA1 and GSTP1, have been examined in many studies because of their genetic variability, which may ... more

M. Skrzypczak-Zielinska; O. Zakerska-Banaszak; B. Tamowicz; I. Sobieraj; N. Drweska-Matelska; M. Szalata; R. Slomski; A. Mikstacki
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Gene expression; Hepatocellular carcinoma; Laser capture microdissection; Microarray

The aim of this study was to identify genomic aberrations in hepatocellular carcinoma (HCC) by using laser capture microdissection (LCM) combined with microarray analysis. Samples were procured by LCM from HCC and patient-matched normal liver tissue surgically resected from 4 patients. RNA was isolated from the samples and reverse transcribed into cDNA. After 2-cycle linear amplification and 2 ... more

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Clinical outcome; Hepatocellular carcinoma; Polymorphism; Vascular endothelial growth factor

We conducted a cohort study to investigate the prognostic significance of vascular endothelial growth factor (VEGF) polymorphisms in hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). In total, 156 patients with histologically confirmed HCC within 2 months were collected from January 2007 to January 2008. The genotypes of VEGF-2578C/A ... more

J. Song; L.Z. Wang; X. Li; T.P. Jiang; T.Z. An; M. Xu; X.P. Wu; S. Zhou

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