Research Article

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Primary open-angle glaucoma (POAG) is characterized by loss of retinal ganglion cells, optic nerve damage and irreversible loss of visual field. Glaucoma is the second leading cause of blindness worldwide. It was estimated that in 2010 there were about 60.5 million glaucoma cases worldwide; among these patients, 4.5 million will become bilaterally blind. Glutathione S-transferases (GST) ... more

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Specific genotypes appear to be related to the development of thyroid disease. We examined whether polymorphisms of the genes CYP1A1, GSTM1, GSTT1, and TP53 at codon 72 are associated with increased risk for thyroid nodules. Blood samples were obtained from 122 thyroid patients with nodules and from 134 healthy control individuals from Goiânia city, GO ... more

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ACE gene; GSTM1; GSTT1; Polymorphism; Retinopathy of prematurity

One of the most frequently observed causes of blindness in infancy is the pathogenesis known as retinopathy of prematurity (ROP). Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system; it is involved in the development of cardiovascular system diseases linked to I/D polymorphism of the ACE gene. Glutathione-S-transferase enzyme (GST) is one of ... more

M. Yildiz; M. Karkucak; T. Yakut; O. Gorukmez; A. Ozmen
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GSTT1; Neoplasia; Polymorphism; Pterygium

Pterygium is an inflammatory and degenerative ocular surface disease in which the conjunctiva on the cornea grows to form a fibrous tissue in the shape of a triangle. The disorder may be characterized by cell proliferation, inflammatory processes, fibrosis, angiogenesis, and destruction of the extracellular matrix. The anomaly is considered a degenerative eye disease and is erroneously ... more

G.Mdos Reis; deP.R. Júnior; K.S.Fe Silva; D.A. Rodrigues; M.C.S. Gomes; J.V.M. Martins; I.R. da Costa; G.A. Freitas; K.K.O. Moura
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GSTM1; Lung cancer; Meta-analysis; Polymorphism

The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform literature ... more

H. Liu; H.F. Ma; Y.K. Chen
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Bombyx mori multiple nucleopolyhedrovirus; Molecular markers; Polymorphism; Random amplified polymorphic DNA; Silkworm

The silkworm Bombyx mori L. is particularly susceptible to virus diseases, especially B. mori nucleopolyhedrovirus (BmNPV). Disease resistance, along with high productivity, are important selection criteria for developing commercial hybrids of B. mori. We used bioassays and molecular markers linked to susceptibility/resistance to baculovirus infection to analyze the ... more

L.F.C. Ribeiro; D.B. Zanatta; J.P. Bravo; R.M.C. Brancalhão; M.A. Fernandez
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Polymorphism; Random amplified polymorphic DNA markers; Table grapes; Vitis vinifera

Random amplified polymorphic DNA (RAPD) markers were used to detect polymorphism and to examine relationships among four table grape clones from northwestern Paraná, in southern Brazil. The 10 primers used for RAPD fingerprints generated 126 reproducible fragments, of which 63, 68, 76, and 72 were polymorphic in cultivars Italia, Rubi, Benitaka, and Brasil, respectively. Among the primers, OPP ... more

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Mitochondrial DNA; Polymorphism; Sea turtles; Single strand conformation polymorphism

Marine turtles are increasingly being threatened worldwide by anthropogenic activities. Better understanding of their life cycle, behavior and population structure is imperative for the design of adequate conservation strategies. The mtDNA control region is a fast-evolving matrilineal marker that has been employed in the study of marine turtle populations. We developed and tested a simple ... more

E.C. Reis; R.M. Albano; A.C.V. Bondioli; L.S. Soares; G. Lôbo-Hajdu; G. Lôbo-Hajdu
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Schistosomiasis remains one of the most prevalent parasitic infections and has significant economic and public health consequences in many developing countries. Economic development and improvement in standard of living in these countries are dependent on the elimination of this odious disease. For the control of Schistosomiasis, understanding the host/parasite association is important, since ... more

A.L.D. Oliveira; D. Da Silva; E.M. Zanotti-Magalhães; E.M. Zanotti-Magalhães; A.Z. Abdel-Hamid; J.T. Ribeiro-Paes
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GSTP1; Kashmir; Polymorphism; Prostate cancer; Restriction digestion; RFLP

Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1. To investigate the GSTP1 Ile105Val genotype ... more

Q. Qadri; A.S. Sameer; Z.A. Shah; A. Hamid; S. Alam; S. Manzoor; M.A. Siddiqi

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